Impulsivity and compulsivity in pathological gambling and obsessive-compulsive disorder

Potenza, Marc N.

doi:10.1590/s1516-44462007000200004

Cited by 79 publications

(27 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In contrast to OCD (Watkins et al, 2005;Chamberlain et al, 2006b), set-shifting was unimpaired in pathological gambling. However, other studies indicate that individuals with pathological gambling score highly on specific measures of compulsivity or harm avoidance, and that measures of impulsivity and compulsivity may change over time (eg, during the course of treatment (Potenza, 2007a;Blanco et al, 2009). These findings suggest that impulsivity and compulsivity are not diametrically opposed and share a complex, orthogonal relationship, with specific disorders showing a predominance of one construct over the other that may shift in a temporally dynamic manner.…”

Section: Icds and Models Of Rewardmentioning

confidence: 99%

“…It may be of particular interest to explore the effects of 5-HT2A and 2C antagonists on DA transmission in this circuitry. These investigations could provide additional insight into aspects such as diminished ventral striatal and VMPFC activation seen across studies involving disorders sharing impulsive and compulsive features, such as pathological gambling and SAs (Reuter et al, 2005;Potenza, 2007a).…”

Section: Integrating Mechanisms Of Inhibitory Control Reward and Damentioning

confidence: 99%

See 1 more Smart Citation

Probing Compulsive and Impulsive Behaviors, from Animal Models to Endophenotypes: A Narrative Review

Fineberg

Potenza

Chamberlain

et al. 2009

Neuropsychopharmacol

Self Cite

579

444

View full text Add to dashboard Cite

Failures in cortical control of fronto-striatal neural circuits may underpin impulsive and compulsive acts. In this narrative review, we explore these behaviors from the perspective of neural processes and consider how these behaviors and neural processes contribute to mental disorders such as obsessive-compulsive disorder (OCD), obsessive-compulsive personality disorder, and impulse-control disorders such as trichotillomania and pathological gambling. We present findings from a broad range of data, comprising translational and human endophenotypes research and clinical treatment trials, focussing on the parallel, functionally segregated, cortico-striatal neural projections, from orbitofrontal cortex (OFC) to medial striatum (caudate nucleus), proposed to drive compulsive activity, and from the anterior cingulate/ventromedial prefrontal cortex to the ventral striatum (nucleus accumbens shell), proposed to drive impulsive activity, and the interaction between them. We suggest that impulsivity and compulsivity each seem to be multidimensional. Impulsive or compulsive behaviors are mediated by overlapping as well as distinct neural substrates. Trichotillomania may stand apart as a disorder of motor-impulse control, whereas pathological gambling involves abnormal ventral reward circuitry that identifies it more closely with substance addiction. OCD shows motor impulsivity and compulsivity, probably mediated through disruption of OFC-caudate circuitry, as well as other frontal, cingulate, and parietal connections. Serotonin and dopamine interact across these circuits to modulate aspects of both impulsive and compulsive responding and as yet unidentified brain-based systems may also have important functions. Targeted application of neurocognitive tasks, receptor-specific neurochemical probes, and brain systems neuroimaging techniques have potential for future research in this field.

show abstract

Section: Icds and Models Of Rewardmentioning

confidence: 99%

Section: Integrating Mechanisms Of Inhibitory Control Reward and Damentioning

confidence: 99%

Probing Compulsive and Impulsive Behaviors, from Animal Models to Endophenotypes: A Narrative Review

Fineberg

Potenza

Chamberlain

et al. 2009

Neuropsychopharmacol

Self Cite

579

444

View full text Add to dashboard Cite

show abstract

“…In accordance, many impulsive and compulsive disorders co-occur in the same person or within families, and there is overlap in treatment response across many of these disorders, implying a shared pathophysiology [63, 72•, 81]. Neuropsychological findings in patients with pathological gambling [82][83][84] and OCD [69,85] also suggest that impulsivity and compulsivity are not diametrically opposed and that they Bshare a complex, orthogonal relationship, with specific disorders showing a predominance of one construct over the other that may shift^dynamically over time [72•]. This may have some ramifications for hypersexual behavior as it seems to share many commonalities with gambling disorders in terms of behavioral dysregulation and associated features (e.g., escapism).…”

Section: Impulsivity Vs Compulsivitymentioning

confidence: 99%

Sexual Impulsivity in Hypersexual Men

Reid

Berlin

Kingston

2015

Curr Behav Neurosci Rep

View full text Add to dashboard Cite

Hypersexual behavior is an emerging construct that is receiving increased attention from both clinicians and researchers. Several theoretical perspectives exist about hypersexuality and its associated characteristics. Although the role of impulsivity and how it might be linked to hypersexuality are still being investigated, this article attempts to highlight some of the important concepts related to impulsivity and how they differ from compulsivity. Findings from the field of neuroscience and psychology are integrated to give readers a broader perspective about existing perspectives about the etiology and mechanisms that might link impulsivity with hypersexual behavior. A theoretical model of sexuality impulsivity among hypersexual individuals is discussed, and we conclude by offering some future possibilities for researchers attempting to understand this construct.

show abstract

“…47 As is the case for other anxiety disorders, the neurobiology of OCD has not been fully established but, together with PTSD, this disorder has been extensively investigated over the last decades. The dominant neurobiological model postulates that abnormalities in the orbitofrontal-striatal-thalamic circuits may be involved in the pathophysiology of OCD.…”

Section: Obsessive-compulsive Disorder (Ocd)mentioning

confidence: 99%

Structural magnetic ressonance imaging in anxiety disorders: an update of research findings

Ferrari

Busatto

McGuire

et al. 2008

Rev. Bras. Psiquiatr.

View full text Add to dashboard Cite

Objective: The aim of the present report is to present a systematic and critical review of the more recent literature data about structural abnormalities detected by magnetic ressonance in anxiety disorders. Method: A review of the literature in the last five years was conducted by a search of the Medline, Lilacs and SciELO indexing services using the following key words : "anxiety", "panic", "agoraphobia", "social anxiety", "posttraumatic" and "obsessive-compulsive", crossed one by one with "magnetic resonance", "voxel-based", "ROI" and "morphometry palavras-chave: "anxiety", "panic", "agoraphobia", "social anxiety", "posttraumatic" e "obsessive-compulsive" cruzadas uma a uma com "magnetic ressonance", "voxel-based", "ROI" e "morphometry

show abstract

Impulsivity and compulsivity in pathological gambling and obsessive-compulsive disorder

Cited by 79 publications

References 2 publications

Probing Compulsive and Impulsive Behaviors, from Animal Models to Endophenotypes: A Narrative Review

Probing Compulsive and Impulsive Behaviors, from Animal Models to Endophenotypes: A Narrative Review

Sexual Impulsivity in Hypersexual Men

Structural magnetic ressonance imaging in anxiety disorders: an update of research findings

Contact Info

Product

Resources

About