volume 26, issue 3, P189-201 2004
DOI: 10.1590/s1516-44462004000300009
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Abstract: Abstract Objective: Changes in the hypothalamic-pituitary-adrenocortical (HPA) system are characteristic of depression. Because the effects of glucocorticoids are mediated by intracellular receptors including, most notably, the glucocorticoid receptor (GR), several studies have examined the number and/or function of GRs in depressed patients. Methods: Review scientific evidences have consistently demonstrated that GR function is impaired in major depression, resulting in reduced GR IntroductionHormones play a…

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