The interface of obesity and depression: risk factors for the metabolic

Licinio, Júlio; Wong, Ma‐Li

doi:10.1590/s1516-44462003000400002

Cited by 20 publications

(10 citation statements)

References 4 publications

(4 reference statements)

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“…This could explain why not all patients with diabetes develop mood disorders. Moreover, in agreement with previous clinical and preclinical studies, our findings reinforce the idea that body weight gain, potentially leading to obesity, represents an important factor in the aetiology of MD (Licinio and Wong, ; Capuron et al ., ; Sharma and Fulton ; André et al ., ). Hence, the phenotype induced by prolonged HFD exposure could be due to changes in leptin action and not necessarily to glucose metabolism.…”

Section: Discussionmentioning

confidence: 99%

High‐fat diet‐induced metabolic disorders impairs 5‐HT function and anxiety‐like behavior in mice

Zemdegs

Quesseveur

Jarriault

et al. 2015

British J Pharmacology

129

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BACKGROUND AND PURPOSEThe link between type 2 diabetes mellitus (T2DM) and depression is bidirectional. However, the possibility that metabolic disorders may elicit anxiogenic-like/depressive-like symptoms or alter the efficacy of antidepressant drugs remains poorly documented. This study explored the influence of T2DM on emotionality and proposed a therapeutic strategy that might be used in depressed diabetic patients. EXPERIMENTAL APPROACHMice were fed a high-fat diet (HFD) and subjected to a full comprehensive metabolic and behavioural analysis to establish correlations between metabolic and psychiatric disorders. In vivo intra-hippocampal microdialysis was also applied to propose a mechanism underpinning the phenotype of mice fed the HFD. Finally, we tested whether chronic administration of the selective 5-HT reuptake inhibitor escitalopram or HFD withdrawal could reverse HFD-induced metabolic and behavioural anomalies. KEY RESULTSThe increased body weight, hyperglycaemia and impaired glucose tolerance in response to HFD were correlated with anxiogeniclike/depressive-like symptoms. Moreover, this phenotype was associated with decreased extracellular 5-HT levels in the hippocampus which may result from increased sensitivity of the dorsal raphe 5-HT 1A autoreceptor. Interestingly, the beneficial effect of prolonged administration of escitalopram was abolished in HFD-fed mice. On the contrary, HFD withdrawal completely reversed metabolic impairments and positively changed symptoms of anxiety, although some behavioural anomalies persisted. CONCLUSIONS AND IMPLICATIONSOur data provide clear-cut evidence that both pathologies are finely correlated and associated with impaired 5-HT mediated neurotransmission in the hippocampus. Further experiments are warranted to define the most adequate strategy for the treatment of such co-morbidity. LINKED ARTICLES

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Section: Discussionmentioning

confidence: 99%

High‐fat diet‐induced metabolic disorders impairs 5‐HT function and anxiety‐like behavior in mice

Zemdegs

Quesseveur

Jarriault

et al. 2015

British J Pharmacology

129

View full text Add to dashboard Cite

show abstract

“…Owing to inactivity, distressed patients may experience weight gain and be more prone to develop obesity. Weight gain and obesity can also be side effects of psychotropic drugs prescribed for affective disorders [73]. Depressed patients who have been hospitalized for cardiovascular disease are also more likely to smoke [74], with smoking probably serving as an 'emotional painkiller'.…”

Section: Behavioral Mechanismsmentioning

confidence: 99%

Psychological vulnerability, ventricular tachyarrhythmias and mortality in implantable cardioverter defibrillator patients: is there a link?

Pedersen

Brouwers

Versteeg

2012

Expert Review of Medical Devices

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“…[1][2][3] Surveys of phenomenology, comorbidity, family history, genetic traits, and pharmacologic treatment responses of mood disorders and the metabolic syndrome suggest that both types of condition may overlap and share striking similarities. [4][5][6] Little is known about the causal relationships and the initial sequence of events triggering and sustaining these complex and interrelated processes. In order to assess the contributions of environmental and lifestyle changes to these two outcomes, we studied a defined ethnic population following immigration with marked changes in social environment.…”

mentioning

confidence: 99%

Elevated cortisol levels and increased rates of diabetes and mood symptoms in Soviet Union-born Jewish immigrants to Germany

et al. 2005

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The interface of obesity and depression: risk factors for the metabolic

Cited by 20 publications

References 4 publications

High‐fat diet‐induced metabolic disorders impairs 5‐HT function and anxiety‐like behavior in mice

High‐fat diet‐induced metabolic disorders impairs 5‐HT function and anxiety‐like behavior in mice

Psychological vulnerability, ventricular tachyarrhythmias and mortality in implantable cardioverter defibrillator patients: is there a link?

Elevated cortisol levels and increased rates of diabetes and mood symptoms in Soviet Union-born Jewish immigrants to Germany

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