NFκB inhibitors as a potential novel hypothesized treatment for psoriasis

Soybean: a Potential Antipsoriasis Agent

“…This immune-mediated disorder is characterized by erythematous scaling plaques ranging extensively in size on the scalp, elbows, knee, and other surfaces of the skin ( 1 ). Importantly, genetic, immunohistochemical, and pharmacologic investigations support a prominent role for nuclear factor kappa B (NFκB) pathway in pathophysiology of psoriasis ( 2 ). Numerous dermatological evidences indicate that tumor necrosis factor (TNF)-α is the pivotal immune mediator involved in psoriasis pathogenesis.…”

Possible implication of vagal nerve stimulation for treating refractory psoriasis

“…Psoriasis is a chronic, relapsing, immune-based skin disease that affects an estimated 1-3% of the world’s population. 1 There is no consensus regarding the exact etiology of psoriasis; among several postulated pathophysiological causes, excessive activity of T cell-mediated immune response, and T-helper (Th) in particular, is the most accepted theory. This is supported by increased levels of pro-inflammatory cytokines, especially tumor necrosis factor (TNF-α) in the serum, skin lesions and joints of these patients.…”