High prevalence of morphological subtype FAB M1 in adults with de novo acute myeloid leukemia in São José dos Campos, São Paulo

Callera, Fernando; Mulin, Carla Cecília; Rosa, Evandro Secchi; Melo, Djanete Barbosa de; Melo, Cláudio Marcelo Tavares Pessoa de

doi:10.1590/s1516-31802006000100010

Cited by 5 publications

(8 citation statements)

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“…Rego et al [6] found completely different percentages of APL in two different cities within Table 3 Lineage demarcation markers expression in acute leukemia Brazil (7.8 and 21% of AML). Most published data indicated the predominance of M1-2 as the most common AML subtypes [5,[9][10][11]. In the current study, the commonest FAB AML subtype was AML-M4/5 (34.5%) and this was in concordance with other published studies who reported marked predominance of M4/5 subtypes varying between 42.2 and 73% of AML cases [4,8].…”

Section: Leukemia Subtypessupporting

confidence: 92%

“…In our study, APL accounted for 23%, while non-APL AML accounted for 77% of all AML cases. Most of the previous studies reported lower APL percentages ranging from 5 to 14% of all AML cases [7][8][9][10][11] while fewer investigators stated nearly similar percentage to our results (24%) [4,5]. Rego et al [6] found completely different percentages of APL in two different cities within Table 3 Lineage demarcation markers expression in acute leukemia Brazil (7.8 and 21% of AML).…”

Section: Leukemia Subtypessupporting

confidence: 73%

“…The high percentage of AML may be due to the large number of adults involved in our study (65.8%). The FAB distribution of AML has been extensively studied by many researchers allover the world [4][5][6][7][8][9][10][11]. In our study, APL accounted for 23%, while non-APL AML accounted for 77% of all AML cases.…”

Section: Leukemia Subtypesmentioning

confidence: 52%

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Flowcytometric Immunophenotypic Profile of Acute Leukemia: Mansoura Experience

Salem

El-Aziz

2011

Indian J Hematol Blood Transfus

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Acute leukemia (AL) displays characteristic patterns of antigen expression, which facilitate their identification and proper classification. The purpose of this study is to evaluate the diagnostic usefulness of commonly used immune-markers for immunophenotyping of AL and to define the best immune-markers to be used for proper diagnosis and classification of AL. Besides, to recognize the frequency of different AL subtypes and the antigen expression profile in our Egyptian patients. We retrospectively analyzed the immunophenotypic data of 164 de novo AL patients from our institution during 2009 and 2010. Among these patients, 68.9% were classified as acute myeloblastic leukemia (AML) while 31.1% classified as acute lymphoblastic leukemia (ALL). The commonest FAB subtype in AML group was AML-M4/5 (34.5%) which may differ from most published data. As regard ALL, there were 74.5% with B-ALL and 25.5% with T-ALL. It was found that combined use of HLADR and CD34 was much more helpful in distinguishing APL from non-APL AML than either of these antigens alone. It was found that cCD79a and CD19 were the most sensitive marker for B-ALL while cCD3, CD7 and CD5 were the most sensitive antigens for T-ALL. Our analysis of AL phenotypes proved that employed antibody panels are adequate for proper diagnosis and classification of AL. Flowcytometry was found to be especially useful in the identification of AML-M0 and differentiation of APL from non-APL AML. Immunophenotyping results and FAB classification of our AL patients were comparable to internationally published studies apart from predominance of AML-M4/5 and more frequent APL.

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Section: Leukemia Subtypessupporting

confidence: 92%

Section: Leukemia Subtypessupporting

confidence: 73%

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Flowcytometric Immunophenotypic Profile of Acute Leukemia: Mansoura Experience

Salem

El-Aziz

2011

Indian J Hematol Blood Transfus

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“…18 In São José dos Campos (state of São Paulo), there was higher prevalence of the M1 subtype, followed by M2. 37 In Rio de Janeiro, there was higher frequency of M2, followed by M3 and M4, which were equally frequent, 31 while in Rio Grande do Sul, higher frequency of M2 was found, followed by M1. 32 In the present study, the increased incidence of the FAB subtype M0 was based on samples obtained from a single institution.…”

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confidence: 88%

Immunophenotypic characterization of acute leukemia at a public oncology reference center in Maranhão, northeastern Brazil

et al. 2011

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CONTEXT AND OBJECTIVES: The incidence of acute leukemia (AL) subtypes varies according to geographical distribution. The aim here was to determine the incidence of morphological and immunophenotypic AL subtypes in the state of Maranhão, Brazil, and to correlate the expression of aberrant phenotypes in children with acute lymphoblastic leukemia (ALL) with prognostic factors. DESIGN AND SETTING: Single prospective cohort study at a public oncology reference center in Maranhão. METHODS: Seventy AL cases were diagnosed between September 2008 and January 2010. For the diagnosis, complete blood cell counts, myelograms (at diagnosis and at the end of the induction phase), cytochemical analysis and immunophenotyping were performed. RESULTS: Among adult patients (n = 22), the incidence of AL types was: ALL (22.7%) and acute myeloid leukemia (AML) (77.3%). The subtype AML M0 occurred most frequently (29.4%). In children (n = 48), the types were: AML (18.7%), most frequently subtype AML M4 (33.4%); biphenotypic acute leukemia (BAL) (4.2%); and ALL (77.1%), including the subtypes B-ALL (72.9%) and T-ALL (27.1%). Among the children with ALL, there were no statistically significant differences between patients with and without aberrant phenotypes, in relation to hematological parameters and treatment response. CONCLUSION: This work demonstrates that the frequencies of AML M0 cases among adults and T-ALL cases among children in Maranhão were high. This suggests that there may be differences in AML subtype incidence, as seen with ALL subtypes, in different regions of Brazil. No association was found between the expression of aberrant phenotypes and prognostic factors, in children with ALL. -T (27,1%). Na LLA, em crianças, não se encontrou diferença estatisticamente significante entre pacientes com e sem fenótipos aberrantes, em relação aos parâmetros hematológicos e resposta ao tratamento. CONCLUSÃO: Esta pesquisa demonstra elevada frequência de casos de LMA M0 em adultos, bem como das LLA-T em crianças no Maranhão, sugerindo que podem haver diferenças na incidência dos subtipos das LMA, assim como dos subtipos de LLA, em diferentes regiões do Brasil. Não foi encontrada associação entre a expressão de fenótipos aberrantes e fatores prognósticos em crianças com LLA.

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“…In the current series we found a higher frequency of the M3 subtype and this finding is similar to that reported for Brazilian patients. (21-24) During the study period, there were only seven reported cases of ALL, thus preventing a more detailed analysis.…”

Section: Discussionmentioning

confidence: 99%

Oncohematological diseases in the Vale do Paraíba, State of São Paulo

Callera¹,

Brasil²,

Casali³

et al. 2011

Rev. Bras. Hematol. Hemoter.

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BackgroundBased on the necessity of detailed information that supports effective strategies to improve cancer outcomes in the different regions of Brazil, the aims of this study were to report demographic aspects and to calculate the prevalence and incidence rates of oncohematological diseases in the region of Vale do Paraíba.MethodsThis is a multicentric prospective study carried out from October 2009 to March 2010. A total of 500 over 19-year-old patients were enrolled. Data such as type of healthcare insurance, gender, age, ethnic classification, place of residence, schooling, income, body mass index, new cases and the period between the first symptoms and a definite diagnosis were collected. The prevalence and incidence rates were calculated according to an estimated number of 1,319,800 inhabitants.ResultsThe prevalence and incidence rates per 100,000 inhabitants in the period of six months were, respectively: acute myeloid leukemia 1.5 and 0.7; acute lymphoblastic leukemia 0.5 and 0.1; chronic lymphocytic leukemia 2.4 and 0.4; chronic myeloid leukemia 6.2 and 0.8; Hodgkin's lymphoma 2.9 and 0.9; non-Hodgkin lymphoma 9.8 and 4.3; multiple myeloma 5.7 and 0.7; myelodysplastic syndromes 2.1 and 0.2 and myeloproliferative syndromes 5.1 and 0.3.ConclusionGiving the paucity of data in this field of investigation, our data may be useful for comparisons with those of other regions of Brazil and will assist in the implementation of treatment programs of oncohematological diseases in this region.

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High prevalence of morphological subtype FAB M1 in adults with de novo acute myeloid leukemia in São José dos Campos, São Paulo

Cited by 5 publications

References 3 publications

Flowcytometric Immunophenotypic Profile of Acute Leukemia: Mansoura Experience

Flowcytometric Immunophenotypic Profile of Acute Leukemia: Mansoura Experience

Immunophenotypic characterization of acute leukemia at a public oncology reference center in Maranhão, northeastern Brazil

Oncohematological diseases in the Vale do Paraíba, State of São Paulo

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