Obstructive jaundice secondary to bile duct involvement with Hodgkin's disease: a case report

Sena, Veruska Di; Thuler, Fernanda Prata Borges Martins; Macedo, Erika P.; Paulo, Gustavo Andrade de; Líbera, Ermelindo Della; Ferrari, Ângelo Paulo

doi:10.1590/s1516-31802005000100007

Cited by 8 publications

(9 citation statements)

References 7 publications

(27 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, toxic hepatitis due to drug treatment, tumor-related hemolysis, and intercurrent infection also may lead to jaundice [7,14,19]. However, although jaundice can arise from many causes, the most common cause is tumor-related compression of the biliary tract [1][2][3][4][5][6]20].…”

Section: Discussionmentioning

confidence: 99%

“…Approximately 1.3% of patients with lymphoma develop extrahepatic biliary obstruction, with a frequency of 0.5% for HD and 0.2%-2% for NHL [1,2,21]. Among all causes of malignant biliary obstruction, NHL is the cause in 1%-2% of patients [21,22].…”

Section: Discussionmentioning

confidence: 99%

“…Of 42 previously reported patients, 27 had lesions in the peripancreatic area, as follows: 16 had lymphoma-related masses [3,4,6,14,[30][31][32], 8 had gastrointestinal lymphoma [4,12,16,29,[33][34][35], 2 had primary pancreatic lymphoma [4,36], and 1 had primary lymphoma of the ampulla of Vater [10]. The other 15 patients had lesions at the hilum: 12 had lymphoma-related masses [2,3,6,14,31] and 3 had primary porta hepatis lymphoma [9,27,28]. In the present study, the level of biliary obstruction was distal CBD in five patients with lesions in the peripancreatic area and proximal CBD in two patients, one of whom had involvement of the peripancreatic and portal hilar lymph nodes; the other had benign biliary stricture.…”

Section: Discussionmentioning

confidence: 99%

“…Bile duct involvement is unusual, and lymphomatous obstruction of the biliary system is a rare cause of jaundice [1,2]. Jaundice that occurs with lymphoma can result from many causes, but the most common cause is tumor-related compression of the biliary tract [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

“…Jaundice that occurs with lymphoma can result from many causes, but the most common cause is tumor-related compression of the biliary tract [3][4][5][6]. Lymphoma can affect the biliary tract by various mechanisms [4,[7][8][9][10][11][12][13] and, on cholangiography, may resemble other causes of obstructive jaundice that are more common [1,2,14]. Chemotherapy with or without radiotherapy is the mainstay of treatment for lymphoma, but whether patients with extrahepatic biliary obstruction need biliary drainage remains controversial.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Biliary Tract Obstruction Secondary to Malignant Lymphoma: Experience at a Referral Center

et al. 2007

View full text Add to dashboard Cite

Lymphoma is a rare cause of biliary obstruction and, on cholangiography, may mimic other causes of obstructive jaundice. The optimum treatment for these patients is unclear. The aim of this study is to evaluate the incidence, clinical and imaging findings, management, and outcome of biliary obstruction caused by lymphoma. Our database was searched retrospectively for patients with biliary obstruction due to lymphoma between 1999 and 2005. Biliary obstruction secondary to lymphoma was found in 7 (0.6%) of 1123 patients with malignant biliary obstruction. One patient had benign biliary obstruction related to lymphoma. Of the eight patients (five male, three female; mean age, 34.50 +/- 17.93 years), four had Hodgkin's disease and four had non-Hodgkin's lymphoma. Biliary obstruction occurred as part of the initial or early presentation of lymphoma in two patients. The most common cause of obstruction was compression of the biliary tract by enlarged lymph nodes (six patients). Cholangiographic appearances were diverse: narrowing of the common bile duct (six patients), splayed and narrowed common bile duct (one patient), and multiple strictures and dilatations of the intrahepatic bile ducts (one patient). Biliary drainage was performed in all patients including endoscopic stent placement in six patients, nasobiliary drainage in one, and choledochoduodenostomy in one. Hyperbilirubinemia resolved in all but one of the patients with a stent; however, none could be maintained in a stent-free condition. Five patients died within 1 year after onset of jaundice. One of the surviving patients developed a late benign stricture at the site of the earlier lymphoma. We conclude that lymphoma should be considered in the differential diagnosis of obstructive jaundice, particularly in younger patients. We suggest that biliary drainage by the endoscopic or percutaneous route is necessary for the treatment of these patients. Late benign strictures may develop. Biliary obstruction is a sign of poor prognosis in lymphoma.

show abstract