ABO, Lewis, secretor and non-secretor phenotypes in patients infected or uninfected by the Helicobacter pylori bacillus

Mattos, Luiz Carlos de; Cintra, Juliana R.; Sanches, Fábio Eduardo; Silva, Rita de Cássia Martins Alves da; Ruiz, Milton Artur; Moreira, Haroldo Wilson

doi:10.1590/s1516-31802002000200006

Cited by 37 publications

(34 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…15 This significant increased incidence of secretor status in blood group O individuals in this study was not, to the best of our knowledge, recorded in the literature reviewed. This may at least, to some extent, explain the low incidence of certain diseases in blood group O individuals.…”

Section: Discussionmentioning

confidence: 44%

Higher frequency of secretor phenotype in O blood group – its benefits in prevention and/or treatment of some diseases

Jaff¹

2010

IJN

View full text Add to dashboard Cite

ABO blood groups and secretor status are important in clinical and forensic medicine and in relation to some diseases. There are geographic and racial differences in their frequencies, but the frequency of secretor status in different ABO blood group systems has not been determined yet. Therefore, the aim of this study was mainly to determine this point. Blood and saliva from 762 randomly selected apparently healthy adult individuals (480 men and 282 women) were examined to determine their ABO and Rhesus blood groups by standard conventional methods, and their secretor status by using Lewis blood grouping and/or hemagglutination inhibition test of saliva. Results showed that 76.1% of the study population were ABH blood group antigens secretors and 23.9% were nonsecretors. The frequencies of secretor status in different ABO blood groups were 70.1% in group A, 67.8% in group B, 67.9% in group AB, and 88.3% in group O. In conclusion, blood group O individuals have significantly higher frequency of secretor status than non-O blood group individuals. This finding would be beneficial to them, protecting them, at least partially, from certain malignancies or allowing them to have less aggressive disease, and this finding might be useful in enhancing further studies and research in this direction.

show abstract

Section: Discussionmentioning

confidence: 44%

Higher frequency of secretor phenotype in O blood group – its benefits in prevention and/or treatment of some diseases

Jaff¹

2010

IJN

View full text Add to dashboard Cite

show abstract

“…Some years ago we reported an association between the O blood group and H. pylori infections in patients who were submitted to gastric endoscopy with our data being subsequently verified by two studies involving adult and infant patients from different regions of Brazil (5,14,15). Observations that emerged from these studies have been supported by several publications over the last few years (1-3, 9, 16).…”

Section: Previous Reports That Suggesting That Infections By the H Psupporting

confidence: 59%

“…H. pylori infection was identified by routine urea breath and urease tests performed in the specialized gastroenterology laboratory. Additionally, for all cases, whether positive, negative or discordant, the presence of infection was confirmed by PCR using gastric biopsy samples as described in our previous report (5). Patients who were pregnant, aged less than 18 years, had gastrointestinal tract hemorrhages or acute gastritis, had used a proton-pump inhibitor in the previous week or had used an H 2 receptor antagonist in the previous 24 hours were excluded from the study.…”

Section: Patient Selectionmentioning

confidence: 99%

See 1 more Smart Citation

ABO blood groups and Helicobacter pylori cagA infection: evidence of an association

Mattos¹,

Cintra²,

Mattos³

et al. 2010

J. Venom. Anim. Toxins incl. Trop. Dis

View full text Add to dashboard Cite

Diseases resulting fromHelicobacter pylori infection appear to be dependent on a host of genetic traits and virulence factors possessed by this microorganism. This paper aimed to investigate the association between the ABO histo-blood groups and H. pylori cagA infections. Genomic DNA samples (n = 110) of gastric biopsies obtained from patients with endoscopic diagnosis of peptic ulcers (n = 25) and chronic active gastritis (n = 85) were analyzed by PCR using specific primers for the cagA gene. Of the samples, 66.4% (n = 73) tested positive and 33.6% (n = 37) negative for the gene. The cagA strain was predominant in peptic ulcers (n = 21; 84.0%) compared with chronic active gastritis (n = 52; 61.2%) (p = 0.05; OR 3.332; 95% CI: 1.050-10.576). Additionally, the cagA strain was prevalent in the type O blood (48/63; 76.2%) compared with other ABO phenotypes (25/47; 53.2%) (p = 0.01; OR 2.816; 95% CI: 1.246-6.364). These results suggest that H. pylori cagA infection is associated with the O blood group in Brazilian patients suffering from chronic active gastritis and peptic ulcers.

show abstract

“…This system is used as a genetic marker in studies of associations with infectious and noninfectious diseases (Mattos et al, 2002). The ABO blood group antigens confers advantage of resistance against certain infectious disease (Reid and Bird, 1990).…”

Section: Discussionmentioning

confidence: 99%

Relationship between ABO Blood Groups and Helicobacter Pylori Infection among Patients with Dyspepsia

Baqir¹,

Al-Sulami²,

Hamadi³

2016

JVM

View full text Add to dashboard Cite

ABO, Lewis, secretor and non-secretor phenotypes in patients infected or uninfected by the Helicobacter pylori bacillus

Abstract: Our results suggest that the infection of H. pylori can be related to ABO blood groups but not to the Lewis blood group nor to secretor and non-secretor phenotypes.

Cited by 37 publications

References 22 publications

Higher frequency of secretor phenotype in O blood group – its benefits in prevention and/or treatment of some diseases

Higher frequency of secretor phenotype in O blood group – its benefits in prevention and/or treatment of some diseases

ABO blood groups and Helicobacter pylori cagA infection: evidence of an association

Relationship between ABO Blood Groups and Helicobacter Pylori Infection among Patients with Dyspepsia

Contact Info

Product

Resources

About

ABO, Lewis, secretor and non-secretor phenotypes in patients infected or uninfected by the Helicobacter pylori bacillus

Abstract: Our results suggest that the infection of H. pylori can be related to ABO blood groups but not to the Lewis blood group nor to secretor and non-secretor phenotypes.

Cited by 37 publications

References 22 publications

Higher frequency of secretor phenotype in O blood group &ndash; its benefits in prevention and/or treatment of some diseases

Higher frequency of secretor phenotype in O blood group &ndash; its benefits in prevention and/or treatment of some diseases

ABO blood groups and Helicobacter pylori cagA infection: evidence of an association

Relationship between ABO Blood Groups and Helicobacter Pylori Infection among Patients with Dyspepsia

Contact Info

Product

Resources

About

Higher frequency of secretor phenotype in O blood group – its benefits in prevention and/or treatment of some diseases

Higher frequency of secretor phenotype in O blood group – its benefits in prevention and/or treatment of some diseases