Prognosis related to staging systems for chronic lymphocytic leukemia

Faria, de; Js, de Oliveira; Rm, Delbone de Faria; Mr, Silva; Goihman, Samuel; Yamamoto, Masahiro; Kerbauy, J

doi:10.1590/s1516-31802000000400002

Cited by 9 publications

(5 citation statements)

References 25 publications

(12 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, our study showed no significant relationship between survival of CLL patients and Rai staging. This finding is inconsistent with results ofde Faria et al 24 study in Brazil which reported a significant association between advanced Rai staging of patients with CLL and shorter survival. This inconsistency might be due to difference in health infrastructure and discrepancy in diagnostic techniques between Hemato/oncology center s of different countries.…”

Section: Discussioncontrasting

confidence: 92%

Outcome of treatment among chronic lymphocytic leukemia and its correlation to Rai staging system in Kurdistan region of Iraq

Ahmad¹,

Hasan²,

Al-Rawi³

et al. 2021

Ann Coll Med Mosul

View full text Add to dashboard Cite

Background: Chronic lymphocytic leukemia is common adulthood leukemia with low incidence in Kurdistan region of Iraq. Staging of chronic lymphocytic leukemia is essential in treatment planning and the pattern of response is variable. Aim of study:To evaluate the Rai staging distribution of patients with chronic lymphocytic leukemia in Kurdistan region/Iraq and its correlation with the treatment outcome. Patients & Methods:A retrospective cross sectional review study conducted in three Hemato/oncology centers in Kurdistan for duration of eleven years through the period from 1 st of January, 2010 to 31 st of December, 2020 on convenient sample of 170chronic lymphocytic leukemia patients. Diagnosis of chronic lymphocytic leukemia was done according to the International Workshop on Chronic Lymphocytic Leukemia. The Rai staging was done by the clinical hematologist in Hemato/oncology center according to clinical evaluation and laboratory investigations. The pattern of the treatment response was determined according to the International Workshop on Chronic Lymphocytic Leukemia (iwCLL) Results: The Rai staging of our patients was 0 in 15.3% of them, stage I in 12.4%, stage II 30%, stage III 13.5% and stage IV 28.8%. The treatment response of studied sample was complete response (43.5%), partial response (17.6%), stable (14.1%), no response (21.8%) and progressive (2.9%).A highly significant association was observed between no response to treatment and advanced Rai staging and also a highly significant association was observed between death outcome of patients and advanced Rai staging. Conclusions: The treatment response of patients with chronic lymphocytic leukemia is directly related to Rai staging as patients with advanced Rai staging had lower treatment response rate.

show abstract

Section: Discussioncontrasting

confidence: 92%

Outcome of treatment among chronic lymphocytic leukemia and its correlation to Rai staging system in Kurdistan region of Iraq

Ahmad¹,

Hasan²,

Al-Rawi³

et al. 2021

Ann Coll Med Mosul

View full text Add to dashboard Cite

show abstract

“…These findings partially agree with those previously reported by Shvidel et al; however, they contradict de Faria et al 's study. 27,28 The difference between these findings is probably due to variations in sample size, the lack of genetic assessment conducted in the current study and the well-known impact of ethnicity. 13 In addition, data regarding CD49d and ZAP70 expression, which have a major prognostic impact on CLL patients, were not available.…”

Section: Discussionmentioning

confidence: 67%

Clinical Aspects, Immunophenotypic Analysis and Survival Rate of Chronic Lymphocytic Leukaemia Patients in Erbil City, Iraq

Hasan

2019

Sultan Qaboos Univ Med J

View full text Add to dashboard Cite

Objectives: Chronic lymphocytic leukaemia (CLL) is characterised by an accumulation of clonal B cells in the blood, bone marrow and lymphatic tissue. This study aimed to evaluate the clinical and immunophenotypic characteristics and survival rate of CLL patients. Methods: This retrospective study was conducted at the Nanakaly Hospital for Blood Diseases & Oncology in Erbil, Iraq, between January 2011 and December 2017. A total of 105 CLL patients were assessed to determine clinical presentation and staging, immunophenotype and survival rate. Results: The median age of the patients was 65 years and 63.8% were male. The main clinical presentations were splenomegaly (64.8%), pallor (61.9%) and lymphadenopathy (60%). More than half of the patients presented at an advanced clinical stage according to the Rai and Binet staging systems (59.1% and 55.2%, respectively). All CLL cases expressed both cluster of differentiation (CD)19 and CD5, 67.6% had monoclonal kappa light chains and 21% expressed CD38. The five-year overall survival (OS) rate was 61.3%. The mean duration of five-year survival was 41.3 months (95% confidence interval: 36.4–46.3 months). There were no correlations between survival and sociodemographic, clinical or laboratory characteristics. Conclusion: In comparison to the existing Western literature, Iraqi CLL patients more frequently presented with hepatosplenomegaly and at a more advanced clinical stage. In addition, the five-year OS rate was much lower.Keywords: Lymphoproliferative Disorders; Chronic Lymphocytic Leukemia; Immunophenotyping; Survival Rates; Iraq.

show abstract

“…But in very studies clear finding of male predominance was stable. Which might be linked to genetic bases as revealed by results described by Cantu ES, McGill JR et al (Cantú et al, 2013) In (Faria et al, 2000) , (Pflug et al, 2014). But according to the data from previous study of Iraq most of patients existing at an advance stage such as Rai stage III or IV (59.1%) Binet stage C (55.2%) (Hasan, 2018), (Naji, 2012).…”

Section: Discussionmentioning

confidence: 97%

The Correlation of initial hematological feature with advanced stage in Chronic Lymphocytic Leukemia in Kurdistan Region of Iraq

2021

ZJPAS

View full text Add to dashboard Cite

Prognosis related to staging systems for chronic lymphocytic leukemia

Cited by 9 publications

References 25 publications

Outcome of treatment among chronic lymphocytic leukemia and its correlation to Rai staging system in Kurdistan region of Iraq

Outcome of treatment among chronic lymphocytic leukemia and its correlation to Rai staging system in Kurdistan region of Iraq

Clinical Aspects, Immunophenotypic Analysis and Survival Rate of Chronic Lymphocytic Leukaemia Patients in Erbil City, Iraq

The Correlation of initial hematological feature with advanced stage in Chronic Lymphocytic Leukemia in Kurdistan Region of Iraq

Contact Info

Product

Resources

About