Polycystic ovary syndrome: clinical and laboratory evaluation

Abstract

Objective: To evaluate clinically, and with laboratory, tests, women with polycystic ovary syndrome (PCO). Patients: One hundred and twelve women with PCO were studied. Methods: The following data was recorded: Current age; age at menarche; menstrual irregularity, occurrence of similar cases in the family; fertility, obstetric history; body mass index (8MI); and presence of hirsutism. Serum measurements of follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin, free testosterone, and dehydroepiandrosterone sulfate were taken. Results: All patients presented either oligomenorrhea (31 percent), periods of secondary amenorrhea (9 percent), or both alterations (60 percent). The majority of the patients were infertile (75.6 percent). The LH/FSH ratio was higher than 2: 1 in 55 percent of the patients and higher than 3: 1 in 26.2 percent. The ultrasonographic aspect of the ovaries~: was considered to be normal in 31 percent. Conclusion: The main clinical feature of the PCO is the irregularity of menses since menarche, and that the laboratory tests would be important to exclude other disorders such as hyperprolactinemia or hyperandrogenemia caused by late-onset congenital adrenal hyperplasia.

The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report

“…In a large series of patients diagnosed with PCOS, approximately 75% to 85% have clinically evident menstrual dysfunction (Table 2) (46,65,(83)(84)(85)(86)(87)(88)(89)(90)(91)(92)(93)(94)(95)(96)(97)(98)(99)(100). However, as many women with potential PCOS do not seek medical care (101), and women with overt abnormalities of vaginal bleeding may be more likely to seek medical care, more accurate estimates of the prevalence of menstrual dysfunction in PCOS may be determined from prospective studies of unselected women.…”

“…The prevalence of polycystic ovaries appears to be relatively high among patients with androgen excess or PCOS (Table 4) (86,88,89,92,93,95,97,99,110,168,175,176). In a study of 173 women with anovulation or hirsutism, polycystic ovaries by ultrasound was found in 92% of women with hirsutism with regular menstrual cycles, 87% of women with oligomenorrhea, 57% of anovulatory women, and 26% of women with amenorrhea (12).…”

“…There are also a number of other disorders that may result in ovulatory dysfunction, including hyperprolactinemia and thyroid abnormalities. Consequently, although PCOS has specific diagnostic criteria, other disorders associated with androgen excess and/or menstrual irregularities should be excluded (Table 5) (46,47,83,84,87,89,110,(226)(227)(228)(229)(230)(231). In the following we review the specific disorders that may require exclusion when defining PCOS.…”

New Criteria for the Clinical Diagnosis of Hyperandrogenism in Polycystic Ovarian Syndrome and the Risk of Overdiagnosis

“…Researchers also suggested the Ferriman-Gallwey (F-G) index as a tool for the diagnosis and follow-up of women with PCOS and hirsutism. However, the great doubt of some researchers is the cutoff point of this index for these recommendations, [6][7][8][9][10] because ethnicity has great relevance in determining hair distribution in women. The most intense hirsutism can be observed in women of the Middle East, of Latin America, and of the Mediterranean.…”

Polimorfismos do gene BMP4 em pacientes com a síndrome dos ovários policísticos

“…(1) . Além disso, apresenta, em número considerável de pacientes, resistência insulínica com hiperinsulinemia compensatória (2,3) .…”