Action of the 4-Nitro-2-phenoximethanesulphonanilide (nimesulide) on neutrophil chemotaxis and superoxide production

Effect of the NSAID nimesulide on the radical scavenger glutathione S‑transferase in patients with osteoarthritis of the knee

“…It can be assumed that, as a result of the high antioxidative potency of nimesulide demonstrated in our study, the drug may have contributed to the increase in glutathione transferases through the reduction of OH • radicals and a decrease in O 2 • radicals and their derivatives (H 2 O 2 , HOCl) 15,20,21 .…”

“…Interestingly, both M1 and M2 metabolites displayed a higher scavenging activity in comparison to nimesulide towards other reactive damaging species, such as R • , RO • and ROO •19 . Other studies showed that nimesulide can restrict the production of superoxide radicals (O 2 • ) which results in a decrease of their oxidative derivatives hydrogen peroxide (H 2 O 2 ) and hypochloric acid (HOCl) 10,16,20,21 . Furthermore, nimesulide inhibits the myeloperoxidase activity involved in the conversion of H 2 O 2 into HOCl 22 .…”

“…Apart from a laboratory test, the symptoms and functional restrictions of the patients were ascertained using the WOMAC Index (Western Ontario and McMaster Universities Osteoarthritis Index) 18 . This was carried out before nimesulide treatment commenced and at the end of weeks 1, 2 and 3. discharge (days [19][20][21]. After separation of the serum by centrifugation (15 min, 1.750 ×g) part of the serum was apportioned for further tests and frozen at -50°C.…”