Effect of porogenic solvent on selective performance of molecularly imprinted polymer for quercetin

Abstract

Molecularly imprinted polymers (MIP's) for quercetin were successfully synthesized by a thermal polymerization method using quercetin as template molecule, acrylamide as functional monomer and ethylene glycol dimethacrylate as cross-linker in the presence of four different porogenic solvents: 1,4-dioxane, tetrahydrofuran (THF), acetone, and acetonitrile. The selective performance of obtained MIP's was evaluated through HPLC analysis. The results indicated that the MIP obtained in THF showed the highest capacity and selectivity. The Scatchard method also supported HPLC results. The results were interpreted by computational quantum chemical analysis through Onsager self-consistent reaction field (SCRF) technique in term of stabilization energy. It was also found that the amount of porogenic solvent used had impact on the adsorption effectiveness of MIP's.

Virtual Searching of Dummy Template for Sinensetin Based on 2d Molecular Similarity Using Chemdb Tool

“…Based on the XlogP value for sinensetin and most of sinensetin-like model which has value of 2.5, it is classified for semi polar properties and then a semi polar solvent can be chosen to be used in the synthesis [29]. Therefore in the synthesis of MIP using this compound as dummy template, semi polar solvent like tetrahydrofuran, chloroform or others can be used.…”

Optimal synthesis of a Ni(II)-dimethylglyoxime ion-imprinted polymer for the enrichment of Ni(II) ions in water, soil and mine tailing samples

“…There are several factors that influence the polymerisation, and hence the subsequent performance of the IIPs. These factors include the nature and masses of monomers Yu and Mosbach, 2000;Okutucu and Telefoncu, 2008;Piletska et al, 2009;Yilmaz et al, 1999;Zhang et al, 2005;Zhang and Li, 2006;Song et al, 2009;He et al, 2007;Kim and Spivak, 2003;Andersson et al, 1999), crosslinkers (Wulff and Sarchan, 1972;Yan and Ramström, 2005;Zhu et al, 2007;Yu and Mosbach, 2000;Okutucu and Telefoncu, 2008;Piletska et al, 2009;Yilmaz et al, 1999;Zhang et al, 2005;Zhang and Li, 2006;Song et al, 2009;He et al, 2007;Kim and Spivak, 2003;Andersson et al, 1999;Holland et al, 2010;Mijangos et al, 2006), porogen (Arshady andMosbach, 1981 andWulff andSarchan, 1972;Yan and Ramström, 2005;Zhu et al, 2007;Yu and Mosbach, 2000;Okutucu and Telefoncu, 2008;Holland et al, 2010;Mijangos et al, 2006;Yoshizako et al, 1998), template (Yilmaz et al, 1999;Zhang and Li, 2006;He et al, 2007;…”

“…There are several approaches that can be used to optimise these parameters (Yu and Mosbach, 2000;Okutucu and Telefoncu, 2008;Piletska et al, 2009;Yilmaz et al, 1999;Zhang et al, 2005;Zhang and Li, 2006;Song et al, 2009;He et al, 2007;Kim and Spivak, 2003;Andersson et al, 1999;Holland et al, 2010;Mijangos et al, 2006;Yoshizako et al, 1998;Chu and Lin, 2003). Most have reported an approach where a single parameter was varied with others kept constant Zhang et al, 2005;Zhang and Li, 2006;Song et al, 2009;Kim and Spivak, 2003;Holland et al, 2010 Yoshizako et al, 1998;Chu and Lin, 2003). However, other groups varied more than one parameter at a time Okutucu and Telefoncu, 2008;Piletska et al, 2009;Yilmaz et al, 1999;Andersson et al, 1999).…”

“…The most important parameters that determine the performance of IIPs are the molar ratios of crosslinkers to monomers (Yan and Ramström, 2005;Zhu et al, 2007;Yu and Mosbach, 2000;He et al, 2007;Spivak, 2005), monomers to template (Yan and Ramström, 2005;Yu and Mosbach, 2000;Yilmaz et al, 1999;Zhang and Li, 2006;He et al, 2007;Kim and Spivak, 2003;Andersson et al, 1999;Spivak, 2005), the volume and type of porogen (Yan and Ramström, 2005;Yu and Mosbach, 2000;Song et al, 2009;He et al, 2007;Yoshizako et al, 1998;Spivak, 2003) and the initiator used (Piletska et al, 2009;Mijangos et al, 2006;Yanagihara et al, 1999). The volume/mass of template used ought to be optimised, because increasing the concentration of the components in the polymerisation mixture will favour an increase in the pre-polymer complex, according to Le Chatelier's principle.…”

“…The nature and volume of the porogenic solvent determines the strength of non-covalent interactions and influences polymer morphology which directly affects the performance of an IIP (Song et al, 2009). Therefore the concentration of the porogen used is very important.…”