Efeito genotóxico e antiproliferativo de Mikania cordifolia (L. F.) Willd. (Asteraceae) sobre o ciclo celular de Allium cepa L.

Dias, Márcia Gonçalves; Canto-Dorow, Thais Scotti do; Coelho, Ana Paula Durand; Tedesco, Solange Bósio

doi:10.1590/s1516-05722014000200006

Cited by 14 publications

(19 citation statements)

References 32 publications

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“…Agreeing with the results obtained in this present study, Dias et al (2014), in a study with aqueous extracts of Mikania cordifolia, also observed presence of chromosomal aberrations, confirming mutagenic action in the cell cycle of A. cepa. Similarly, Knoll et al (2006), working with different populations of Pterocaulon polystachyum, demonstrated that the increase in leaf infusion concentrations caused a genotoxic effect on the test organism.…”

Section: Resultssupporting

confidence: 91%

Cytotoxic and Genotoxic Effects of Macroptilium lathyroides

et al. 2018

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The monitoring of phytochemicals with potentially toxic properties can be assessed by observing the physiological and cellular alterations of the test organism exposed. This present study aimed to evaluate the cytotoxic and genotoxic potential of aqueous extracts of leaves and roots of Macroptilium lathyroides weed on the cell cycle of lettuce. Bioassays were conducted in a germinator (25 oC) with aqueous extract at concentrations of 0, 5, 10, 20 and 40% p v-1, obtained from fresh leaves and roots. For biological, lettuce root meristems were used for the preparation of slides using the technique of squashing. All blades were observed with an optical microscope at a magnitude of 400x. A total of 5,000 cells were analyzed for each treatment, and the number of cells in each phase of mitosis was recorded. Possible presence of chromosomal abnormalities was verified, such as chromatid breaks, anafasic bridges, loss of whole chromosomes or micronuclei formation. These analyzes were conducted only on a qualitative level. Results showed that aqueous extracts of M. lathyroides mitotic caused reduced index with increased concentration. Genotoxic activity was also observed for both extracts tested, since composition resulted in cell cycle changes and chromosomal abnormalities.

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Section: Resultssupporting

confidence: 91%

Cytotoxic and Genotoxic Effects of Macroptilium lathyroides

et al. 2018

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“…Pers., Mikania glomerata Spreng., Mikania cordifolia (L. f.) Willd. and Eugenia uniflora L., investigated by Tedesco (2009), Nora et al (2010), Dias et al (2014) and Kuhn et al (2015), respectively.…”

Section: Resultsmentioning

confidence: 99%

Assessment of the antiproliferative and antigenotoxic activity and phytochemical screening of aqueous extracts of Sambucus australis Cham. & Schltdl. (ADOXACEAE)

Tedesco

Kuhn

Frescura

et al. 2017

An. Acad. Bras. Ciênc.

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The purpose of this study was to evaluate the antiproliferative and antigenotoxic activity of Sambucus australis Cham. & Schltdl. aqueous extracts on the cell cycle of Allium cepa L. as well as determine the phenolic compounds in such extracts. S. australis inflorescences and leaves of two accessions were used for aqueous extract preparation at concentrations: 0.003 g/ml and 0.012 g/ml. A. cepa bulbs were rooted in distilled water and, subsequently, placed in treatments for 24 hours. Rootlets were collected and fixed in modified Carnoy's solution for 24 hours and kept. The squash technique was performed for slide preparation. Root tips were smashed and stained with 2% acetic orcein, and a total of 4000 cells per treatment were analyzed. The phenolic compounds were determined using high-performance liquid chromatography and data was analyzed using the Scott-Knott test. The results show that S. australis aqueous extracts have antiproliferative potential. Besides, the extracts prepared from S. australis leaves of both accessions at a concentration of 0.012 g/ml have shown antigenotoxic activity. The phytochemical analysis allowed us to determine the presence of flavonoids and phenolic acids, of which kaempferol and chrologenic acid were the most predominant compounds in the extracts from the inflorescences and leaves, respectively.

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“…Previous data have revealed that M. cordifolia has antiinflammatory (Peluso et al, 1995), insecticidal, trypanocidal (Arias et al, 1995;Muelas-Serrano et al, 2000), genotoxic and antiproliferative (Dias et al, 2014) activities. M. glomerata is the most common among the genus and it has many properties such as anti-inflammatory, antitussive and bronchodilatadory agents (Gasparetto et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Comparative morphoanatomical analysis of Mikania species

Almeida

Hirt

Raeski

et al. 2017

Revista Brasileira de Farmacognosia

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Please cite this article in press as: de Almeida, V.P., et al. Comparative morphoanatomical analysis of Mikania species. Revista Brasileira de Farmacognosia (2016), http://dx. a b s t r a c tMikania belongs to the Asteraceae family and includes a wide range of promising pharmacological activities. Several species of Mikania, which is popularly known in Brazil as "guaco", occur in Southern Brazil and their external morphology is similar. The aim of this study was to investigate the morpho-anatomical characteristics of the leaf and stem of Mikania campanulata, Mikania cordifolia, Mikania glomerata, Mikania hastato-cordata, Mikania microptera and Mikania sessilifolia as a means of providing additional support for differentiating these taxa. The leaves and stems were investigated by employing scanning electron microscopy and light microscopy techniques. The morphological features of Mikania spp. leaves make it possible to differentiate between the species; nevertheless, when the plants were fragmented or pulverized the anatomical features of the leaves and stems supplied additional helpful data in this regard. The main anatomical characteristics were presence of hypodermis and lens shaped epidermal cells, set of trichomes; midrib, petiole and stem shape and vascular pattern; sclerenchymatous ring in the cortex, sclerenchymatous cells and secretory ducts in the pith.

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Efeito genotóxico e antiproliferativo de Mikania cordifolia (L. F.) Willd. (Asteraceae) sobre o ciclo celular de Allium cepa L.

Cited by 14 publications

References 32 publications

Cytotoxic and Genotoxic Effects of Macroptilium lathyroides

Cytotoxic and Genotoxic Effects of Macroptilium lathyroides

Assessment of the antiproliferative and antigenotoxic activity and phytochemical screening of aqueous extracts of Sambucus australis Cham. & Schltdl. (ADOXACEAE)

Comparative morphoanatomical analysis of Mikania species

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