“…The hypotensive and diuretic effects of A. zerumbet leaves were reported (Mendonça et al, 1991;Albuquerque et al, 2008;Oliveira et al, 2015) and antimicrobial activities of their essential oils were presented. The leaves, flowers, and rhizome of this plant also have antihisteric, stomatal, and vermicide properties (Correa et al, 2010) and recently it has been reported to have potential use as anti-Alzheimer's disease (Rao et al, 2014). Rao et al (2014) prepared a hexane fruit shell extract of A. zerumbet and isolated two compounds (kavalactones dihydro-5,6dihydrokavain, and 5,6-dihydrokavain (1, 5, 10, and 50 mM) that had a protective effect against H 2 O 2 oxidative stress-induced PC12 cell death after pretreatment for 6 h. This effect was mediated by the regulation of pkt-A, p38 mitogen-activated protein kinase kinase and oxidative status, suggesting that kavalactones dihydro-5,6-dihydrokavain and 5,6dehidrokavaincould are a potential therapeutic agent for controlling and preventing neurodegenerative diseases such as AD (Table No.…”