Perfil epidemiológico dos casos de tuberculose multirresistente do Espírito Santo

Vieira, Rafael da Cruz Araújo; Fregona, Geisa; Palaci, Moisés; Dietze, Reynaldo; Maciel, Ethel Leonor Nóia

doi:10.1590/s1415-790x2007000100007

Cited by 16 publications

(34 citation statements)

References 14 publications

(14 reference statements)

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“…The cases of MDR-TB that were identified in Santos were similar to those described in other studies conducted in Brazil (Telles et al 2005, Dalcomo et al 2007, Vieira et al 2007, Brito 2010, Santos 2010) in that the cases involved predominantly working-age males and two-thirds of the cases had a prior history of TB treatment. Supervised treatment was lower than that recommended by the NTCP.…”

Section: Discussionsupporting

confidence: 83%

A study of multidrug-resistant tuberculosis in risk groups in the city of Santos, São Paulo, Brazil

Coelho

Zamarioli

Telles

et al. 2012

Mem. Inst. Oswaldo Cruz

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Monitoring the extent of and trends in multidrug-resistant tuberculosis (MDR-TB) is a priority of the Brazilian National Tuberculosis Control Programme. The current study aimed to estimate the incidence of MDR-TB, describe the profile of TB drug resistance in risk groups and examine whether screening for MDR-TB adhered to the recommended guidelines. A descriptive study that examined diagnosed cases of pulmonary TB was conducted in the city of Santos, Brazil, between 2000–2004. Of the 2,176 pulmonary TB cases studied, 671 (30.8%) met the criteria for drug sensitivity testing and, of these cases, 31.7% (213/671) were tested. Among the tested cases, 9.4% were resistant to one anti-TB drug and 15% were MDR. MDR was observed in 11.6% of 86 new TB cases and 17.3% of 127 previously treated cases. The average annual incidence of MDR-TB was 1.9 per 100,000 inhabitants-years. The extent of known MDR-TB in the city of Santos is high, though likely to be underestimated. Our study therefore indicates an inadequate adherence to the guidelines for MDR-TB screening and suggests the necessity of alternative strategies of MDR-TB surveillance.

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Section: Discussionsupporting

confidence: 83%

A study of multidrug-resistant tuberculosis in risk groups in the city of Santos, São Paulo, Brazil

Coelho

Zamarioli

Telles

et al. 2012

Mem. Inst. Oswaldo Cruz

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“…It was also higher than that estimated by the WHO for Brazil (1.4%) and for Latin America (3.5%), although it was close to that found for Argentina in 2005 (4.4%). (11) In addition, it was higher than the rate found for Brazil in the last national survey (2.2%) (17) and the rate found for the state of Espírito Santo (0.87%) (20) ; however, it was lower than the rate found for the state of Rio de Janeiro (10.6%). (22) In the present study, the mean rate for CR to at least one drug was 18.3% (range, 13.5-21.4%).…”

Section: Discussionmentioning

confidence: 85%

Perfil de resistência de Mycobacterium tuberculosis no estado de Mato Grosso do Sul, 2000-2006

et al. 2010

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Objective: To determine the drug resistance profile of Mycobacterium tuberculosis in the state of Mato Grosso do Sul, Brazil, between 2000 and. Methods: Descriptive study of reported tuberculosis cases in the Brazilian Case Registry Database. We included only those cases in which M. tuberculosis culture was positive and sensitivity to drugs (rifampicin, isoniazid, streptomycin and ethambutol) was tested. Löwenstein-Jensen and Ogawa-Kudoh solid media were used for cultures, as was an automated liquid medium system. Sensitivity tests were based on the proportion method. Results: Among the 783 cases evaluated, males predominated (69.7%), as did patients in the 20-49 year age bracket (70%), a diagnosis of pulmonary tuberculosis (94.4%) and positive HIV serology (8.6%); 645 (82.4%) were new cases, and 138 (17.6%) had previously been treated. Resistance to at least one drug was found in 143 cases (18.3%). The primary resistance (PR) rate was, respectively, 8.1%, 1.6%, 2.8% and 12.4%, for monoresistance, multidrug resistance (MDR), other patterns of resistance and resistance to at least one drug, whereas the acquired resistance (AR) rate was 14.5%, 20.3%, 10.9% and 45.7%, respectively, and the combined resistance (CR) rate was 9.2%, 4.9%, 4.2% and 18.3%, respectively. In PR, streptomycin was the most common drug, whereas isoniazid was the most common in AR and CR (7.2% and 3.7%, respectively). Conclusions: These high levels of resistance undermine the efforts for tuberculosis control in Mato Grosso do Sul. Acquired MDR was 12.7 times more common than was primary MDR, demonstrating that the previous use of drug therapy is an indicator of resistance. These levels reflect the poor quality of the health care provided to these patients, showing the importance of using the directly observed treatment, short course strategy, as well as the need to perform cultures and sensitivity tests for the early diagnosis of drug resistance.Keywords: Tuberculosis; Drug resistance, multiple; Mycobacterium tuberculosis. ResumoObjetivo: Determinar o perfil de resistência a drogas de Mycobacterium tuberculosis no estado de Mato Grosso do Sul no período entre 2000 e 2006. Métodos: Estudo descritivo de casos notificados de tuberculose no Sistema de Informação de Agravos de Notificação, com cultura positiva para M. tuberculosis e testes de sensibilidade a rifampicina, isoniazida, estreptomicina e etambutol. Para as culturas, utilizaram-se os meios sólidos Löwenstein-Jensen e Ogawa-Kudoh, assim como um sistema automatizado com meio líquido; para os testes de sensibilidade, o método das proporções. Resultados: De 783 casos, 69,7% eram de pacientes masculinos, na faixa etária de 20-49 anos (70%), com forma pulmonar (94,4%) e sorologia positiva para HIV (8,6%); 645 (82,4%) eram casos novos, e 138 (17,6%) eram casos tratados. Identificou-se qualquer resistência em 143 casos (18,3%). A taxa de resistência primária (RP) foi, respectivamente, 8,1%, 1,6%, 2,8% e 12,4%, para monorresistência, multirresistência (MR), outros padrões de associação de...

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“…The predominance of men, Afro-Brasilian, young people, and people with low levels of education was also found in other municipal, state and local studies between 2000 and 2013; with an exception in the municipality of Porto Alegre, in the state of Rio Grande do Sul, between 2006 and 2007, when most DR-TB cases (64.3%) were w hite individuals. [5][6][7][8][9][17][18][19][20] This variation is possibly due to regional differences in the ethnic composition of population. The DR-TB case profile is the same as that associated with treatment of drug-sensitive TB cases loss to follow-up.…”

Section: Discussionmentioning

confidence: 99%

Caracterização da tuberculose drogarresistente no Brasil, 2014*

Jacobs

Pinto

2020

Epidemiologia e Serviços de Saúde

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Objective: to describe drug-resistant tuberculosis (DR-TB) notifications in Brazil. Methods: this is a descriptive study of clinical and epidemiological characteristics of DR-TB notifications in 2014 on SITETB and TBWeb, these being information systems on which cases involving special treatment regimens are registered. Results: there were 1,574 cases, 94.8% of which had the pulmonary form, 27.6% involved primary resistance, and 50.9% were multidrug-resistant; 70.6% of cases were male, 87.0% were between 20 and 59 years old, 60.9% were of Afro-Brazilian, and 68.0% had less than 8 years of schooling; as for comorbidities, 13.1% of patients had AIDS, 11.3% had diabetes, 25.8% made harmful use of alcohol, 21.0% were illegal drugs users, and 22.2% were tobacco users. Conclusion: the majority of DR-TB notifications were related to men, young people, Afro-Brazilian and people with low levels of education; there was a high percentage of primary resistance, as well as multidrug-resistance and comorbidities, with emphasis on substance use.

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Perfil epidemiológico dos casos de tuberculose multirresistente do Espírito Santo

Cited by 16 publications

References 14 publications

A study of multidrug-resistant tuberculosis in risk groups in the city of Santos, São Paulo, Brazil

A study of multidrug-resistant tuberculosis in risk groups in the city of Santos, São Paulo, Brazil

Perfil de resistência de Mycobacterium tuberculosis no estado de Mato Grosso do Sul, 2000-2006

Caracterização da tuberculose drogarresistente no Brasil, 2014*

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