Interferência dos ácidos graxos ômega-3 nos lipídeos sangüíneos de ratos submetidos ao exercício de natação

Moritz, Bettina; Wazlawik, Elisabeth; Minatti, Jaqueline; Miranda, Rafaella Cristina Dimbarre de

doi:10.1590/s1415-52732008000600005

Cited by 2 publications

(1 citation statement)

References 24 publications

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“…The plasma glucose levels did not differ significantly from those of the control group, which was also observed by Simão et al 31 and Wilkson et al 32 while supplementing a human diet with fish oil. Mortiz et al 33 stated that rats fed with chow enriched with fish oil tended to have lower blood glucose, total cholesterol, and LDL-c and higher TG than the control group. Many works have showed that lipid metabolism is regulated by leptin, a protein hormone produced mainly by adipose tissue 34 .…”

Section: Discussionmentioning

confidence: 99%

Effect of fatty Amazon fish consumption on lipid metabolism

et al. 2014

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OBJECTIVE: The present study aimed to evaluate the effect of feeding diets enriched with fatty fish from the Amazon basin on lipid metabolism. METHODS: Male Wistar rats were divided into four groups: control group treated with commercial chow; Mapará group was fed diet enriched with Hypophthalmus edentatus; Matrinxã group was fed diet enriched with Brycon spp.; and, Tambaqui group was fed diet enriched with Colossoma macropomum. Rats with approximately 240g±0.60 of body weight were fed ad libitum for 30 days, and then were sacrificed for collection of whole blood and tissues. RESULTS: The groups treated with enriched diets showed a significant reduction in body mass and lipogenesis in the epididymal and retroperitoneal adipose tissues and carcass when compared with the control group. However, lipogenesis in the liver showed an increase in Matrinxã group compared with the others groups. The levels of serum triglycerides in the treated groups with Amazonian fish were significantly lower than those of the control group. Moreover, total cholesterol concentration only decreased in the group Matrinxã. High Density Lipoprotein cholesterol levels increased significantly in the Mapará and Tambaqui compared with control group and Matrinxã group. The insulin and leptin levels increased significantly in all treatment groups. CONCLUSION: This study demonstrated that diets enriched with fatty fish from the Amazon basin changed the lipid metabolism by reducing serum triglycerides and increasing high density lipoprotein-cholesterol in rats fed with diets enriched with Mapará, Matrinxã, and Tambaqui.

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Section: Discussionmentioning

confidence: 99%

Effect of fatty Amazon fish consumption on lipid metabolism

et al. 2014

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n-3 PUFA and obesity: from peripheral tissues to the central nervous system

et al. 2018

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The current paradigms of prevention and treatment are unable to curb obesity rates, which indicates the need to explore alternative therapeutic approaches. Obesity leads to several damages to the body and is an important risk factor for a number of other chronic diseases. Furthermore, despite the first alterations in obesity being observed and reported in peripheral tissues, studies indicate that obesity can also cause brain damage. Obesity leads to a chronic low-grade inflammatory state, and the therapeutic manipulation of inflammation can be explored. In this context, the use of n-3 PUFA (especially in the form of fish oil, rich in EPA and DHA) may be an interesting strategy, as this substance is known by its anti-inflammatory effect and numerous benefits to the body, such as reduction of TAG, cardiac arrhythmias, blood pressure and platelet aggregation, and has shown potential to help treat obesity. Thereby, the aim of this narrative review was to summarise the literature related to n-3 PUFA use in obesity treatment. First, the review provides a brief description of the obesity pathophysiology, including alterations that occur in peripheral tissues and at the central nervous system. In the sequence, we describe what are n-3 PUFA, their sources and their general effects. Finally, we explore the main topic linking obesity and n-3 PUFA. Animal and human studies were included and alterations on the whole organism were described (peripheral tissues and brain).

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Interferência dos ácidos graxos ômega-3 nos lipídeos sangüíneos de ratos submetidos ao exercício de natação

Cited by 2 publications

References 24 publications

Effect of fatty Amazon fish consumption on lipid metabolism

Effect of fatty Amazon fish consumption on lipid metabolism

n-3 PUFA and obesity: from peripheral tissues to the central nervous system

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