Consumo de cafeína e prematuridade

Abstract

A cafeína (1, 3, 7-trimetilxantina) é uma metilxantina que facilmente atravessa a barreira placentária, com quantidades substanciais passando para o líquido amniótico, sangue do cordão umbilical, plasma e urina dos neonatos. As maiores fontes de cafeína são café, chá, chocolate e refrigerantes do tipo cola. Além disso, cerca de mil drogas prescritas e 2 mil drogas não prescritas contêm cafeína, e 25 dessas drogas podem ser usadas na gravidez. Embora estudos em animais indiquem que a cafeína leve à diminuição no crescimento intrauterino fetal, redução do peso ao nascer, reabsorção fetal e teratogênese, nos estudos epidemiológicos os achados são, ainda, inconclusivos. Pelo fato de os alimentos com cafeína serem amplamente consumidos na gravidez, é importante avaliar se o uso dessa substância está associado com a redução da idade gestacional. Este artigo examina o conhecimento atual do consumo de cafeína durante a gravidez, abordando os estudos epidemiológicos sobre a associação entre consumo de cafeína e prematuridade, as fontes de cafeína e seu consumo na gravidez, a bioquímica, a fisiopatologia e a plausibilidade biológica da associação e as principais limitações dos estudos sobre cafeína e prematuridade.

Caffeine challenge test and panic disorder: a systematic literature review

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Enhancement of water and salt penetration resistance into mortar cement composited with vulcanized natural rubber compound

“…There are many kinds of latex products such as gloves, condoms, and baby bottle pacifiers. Latex film and latex product qualities are further dependent on the types of polymer latex used, solid content, pH, density, and formation temperature 14–17 . Natural rubber latex has several advantages, including being environmentally benign, sustainable, non‐toxic, inexpensive, and abundant in Thailand.…”

“…Latex film and latex product qualities are further dependent on the types of polymer latex used, solid content, pH, density, and formation temperature. [14][15][16][17] Natural rubber latex has several advantages, including being environmentally benign, sustainable, nontoxic, inexpensive, and abundant in Thailand. The use of vulcanized natural rubber compound as a dispersed phase affects the characteristics of mortar cement-based S C H E M E 1 (a) Structure of natural rubber latex; (b) crosslinking of natural rubber latex compound or vulcanized natural rubber; and (c) arrangement of NR particlesmortar composite materials.…”

Osteogenic potential of osteoblasts from neonatal rats born to mothers treated with caffeine throughout pregnancy

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