2011
DOI: 10.1590/s1415-47572011005000013
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Abstract: Rapidly proliferating tissue may require enhanced DNA repair capacity in order to avoid fixation of promutagenic DNA lesions to mutations. Partial hepatectomy (PH) triggers cell proliferation during liver regeneration (LR). However, little is known on how DNA repair genes change and how they are regulated at the transcriptional level during LR. In the present study, the Rat Genome 230 2.0 array was used to detect the expression profiles of DNA repair genes during LR, and differential expression of selected gen… Show more

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Cited by 8 publications
(3 citation statements)
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“…Research shows that Cd can completely inhibit the enzyme activity of animal hOGG1 and increase 8-OHdG in target organs. Thus, 8-OHdG inhibited hOGG1 gene expression (Van Duin et al, 1986;Wang and Xu, 2011).…”
Section: Discussionmentioning
confidence: 92%
“…Research shows that Cd can completely inhibit the enzyme activity of animal hOGG1 and increase 8-OHdG in target organs. Thus, 8-OHdG inhibited hOGG1 gene expression (Van Duin et al, 1986;Wang and Xu, 2011).…”
Section: Discussionmentioning
confidence: 92%
“…The reliability of the mRNA microarray data has been validated by qRT-PCR by several previous studies in our lab. The expressions of several target genes, including Trim24, Jun, Myc, Icam1, G6pc, Mgmt, Pcna, Hmgn1, Spp1, Ikbkb, Fos, and Bcl2 were respectively confirmed in regenerating liver tissues in three references [27][28][29]. To validate the reliability of miRNA high-throughput sequencing data, six rat liver regeneration-related miRNAs (miR-143, miR-181c, miR-182, miR-183, miR-199a, and miR-429) were selected by Geng et al [30] for qRT-PCR validation.…”
Section: Identification Of Lr-associated Mrnas Mirnas and Circrnasmentioning
confidence: 93%
“…Transcription profiles of eight kinds of regenerating hepatic cells were individually determined by Rat Genome 230 2.0 chips as previously described, including cDNA synthesis, in vitro transcription, cRNA hybridization, microarray wash, and image scanning (Wang and Xu, 2011). After microarray detection, the generated images were converted into normalized signal values, signal detection P, and experiment/control ratios by using Affymetrix GCOS 2.0 software.…”
Section: Microarray Detection and Data Analysismentioning
confidence: 99%