Association of PPARγ2 polymorphisms with carcass and meat quality traits in a Pietrain x Jinhua F2 population

Chen, Zhe; Zhao, Xiaofeng; Jiang, Xiaoling; Xia-zhen, Guo; Lv, Zunzhou; Zhou, Hongmei; Xu, N.

doi:10.1590/s1415-47572010005000107

Cited by 11 publications

(6 citation statements)

References 34 publications

(36 reference statements)

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“…Interestingly, in another study of our group, PPARγ was identified as over-expressed in pigs having more MUFA and SFA versus pigs with high PUFA content [20] . Other studies in pigs suggested that PPAR γ is an excellent target for determining growth and fat deposition traits at a certain age in pigs [21] , [22] .…”

Section: Resultsmentioning

confidence: 98%

A Co-Association Network Analysis of the Genetic Determination of Pig Conformation, Growth and Fatness

et al. 2014

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BackgroundSeveral QTLs have been identified for major economically relevant traits in livestock, such as growth and meat quality, revealing the complex genetic architecture of these traits. The use of network approaches considering the interactions of multiple molecules and traits provides useful insights into the molecular underpinnings of complex traits. Here, a network based methodology, named Association Weight Matrix, was applied to study gene interactions and pathways affecting pig conformation, growth and fatness traits.ResultsThe co-association network analysis underpinned three transcription factors, PPARγ, ELF1, and PRDM16 involved in mesoderm tissue differentiation. Fifty-four genes in the network belonged to growth-related ontologies and 46 of them were common with a similar study for growth in cattle supporting our results. The functional analysis uncovered the lipid metabolism and the corticotrophin and gonadotrophin release hormone pathways among the most important pathways influencing these traits. Our results suggest that the genes and pathways here identified are important determining either the total body weight of the animal and the fat content. For instance, a switch in the mesoderm tissue differentiation may determinate the age-related preferred pathways being in the puberty stage those related with the miogenic and osteogenic lineages; on the contrary, in the maturity stage cells may be more prone to the adipocyte fate. Hence, our results demonstrate that an integrative genomic co-association analysis is a powerful approach for identifying new connections and interactions among genes.ConclusionsThis work provides insights about pathways and key regulators which may be important determining the animal growth, conformation and body proportions and fatness traits. Molecular information concerning genes and pathways here described may be crucial for the improvement of genetic breeding programs applied to pork meat production.

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Section: Resultsmentioning

confidence: 98%

A Co-Association Network Analysis of the Genetic Determination of Pig Conformation, Growth and Fatness

et al. 2014

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“…IMF is an important pork meat quality trait, which can influence tenderness, juiciness and the flavor of pork meat, but it is difficult to increase IMF and lean meat content at the same time by traditional breeding methods. Previous studies have shown that IMF is associated with PPARγ expression (Chen et al, 2011;Grindflek et al, 2001). Therefore, we investigated whether overexpression of PPARγ in muscles can promote the increase of IMF.…”

Section: Discussionmentioning

confidence: 94%

Targeted over-expression of PPARγ in pig skeletal muscle improves oxidative fiber formation and intramuscular fat deposition

Zhou

Yang

et al. 2020

Preprint

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PPARγ is a master regulator of adipogenesis and lipogenesis. To understand its roles in fat deposition and fiber formation in skeletal muscle, we successfully generated muscle-specific overexpression of PPARγ by pig cloning procedures. The content of intramuscular fat was significantly increased in PPARγ transgenic pigs while the muscle mass as lean percentage of body weight was not changed. The proteomics analysis demonstrated oxidative metabolism of fatty acids and respiratory chain were increased in PPARγ pigs. Furthermore, expressions of oxidative muscle fiber-related genes such as MyHC1 and TNNT1 were enhanced. CAMK2, MEF2 and PGC1α were also significantly increased in skeletal muscle of PPARγ pigs, indicating that Ca2+-sensitive phosphatases and kinases may play an important role in the switch of muscle fiber types when PPARγ activity is elevated in skeletal muscle. The results support skeletal muscle-specific overexpression of PPARγ can promote oxidative fiber formation and intramuscular fat deposition in pigs.

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“…More recent studies of gene polymorphisms that are associated with increased BF include LEPR (165), TGFBR1 (166), MC4R (167), and PPARg2 gene haplotypes (168). In contrast, a decrease in BF is associated with polymorphisms in CTSK, GFAT1, IGF2, LEPR, IL-6, LEP, PPARGCIA, PPRD, RETN, TNN12, FABP5, and MC4R genes (2,132).…”

Section: Identification Of Genes Influencing Adipose Tissue Differentmentioning

confidence: 99%

“…Often, a gene polymorphism that is associated with BF thickness may also be associated with other carcass traits (132,(166)(167)(168)171). This is especially poignant when both IM and BF accretion are genetically upregulated in a given study and the IM accretion is desirable but BF accretion is not.…”

Section: Identification Of Genes Influencing Adipose Tissue Differentmentioning

confidence: 99%

Preadipocyte and Adipose Tissue Differentiation in Meat Animals: Influence of Species and Anatomical Location

Hausman¹,

Basu

Wei

et al. 2014

Annu. Rev. Anim. Biosci.

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Early in porcine adipose tissue development, the stromal-vascular (SV) elements control and dictate the extent of adipogenesis in a depot-dependent manner. The vasculature and collagen matrix differentiate before overt adipocyte differentiation. In the fetal pig, subcutaneous (SQ) layer development is predictive of adipocyte development, as the outer, middle, and inner layers of dorsal SQ adipose tissue develop and maintain layered morphology throughout postnatal growth of SQ adipose tissue. Bovine and ovine fetuses contain brown adipose tissue but SQ white adipose tissue is poorly developed structurally. Fetal adipose tissue differentiation is associated with the precocious expression of several genes encoding secreted factors and key transcription factors like peroxisome proliferator activated receptor (PPAR)γ and CCAAT/-enhancer-binding protein. Identification of adipocyte-associated genes differentially expressed by age, depot, and species in vivo and in vitro has been achieved using single-gene analysis, microarrays, suppressive subtraction hybridization, and next-generation sequencing applications. Gene polymorphisms in PPARγ, cathepsins, and uncoupling protein 3 have been associated with back fat accumulation. Genome scans have mapped several quantitative trait loci (QTL) predictive of adipose tissue-deposition phenotypes in cattle and pigs.

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Association of PPARγ2 polymorphisms with carcass and meat quality traits in a Pietrain x Jinhua F2 population

Cited by 11 publications

References 34 publications

A Co-Association Network Analysis of the Genetic Determination of Pig Conformation, Growth and Fatness

A Co-Association Network Analysis of the Genetic Determination of Pig Conformation, Growth and Fatness

Targeted over-expression of PPARγ in pig skeletal muscle improves oxidative fiber formation and intramuscular fat deposition

Preadipocyte and Adipose Tissue Differentiation in Meat Animals: Influence of Species and Anatomical Location

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