Assessment of the genotoxic impact of pesticides on farming communities in the countryside of Santa Catarina State, Brazil

Salvagni, Jaqueli; Ternus, Raquel Zeni

doi:10.1590/s1415-47572010005000104

Cited by 29 publications

(13 citation statements)

References 30 publications

(35 reference statements)

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“…Castilhos Júnior and Oliveira (2000) stated that in the region of the Hydrographic Basin of Cubatão do Sul River, 95% of farms spray their crops with pesticides approximately five times a week. Brazil is the world's largest consumer of pesticides (Carneiro et al, 2012), and the main pesticides used in the state of Santa Catarina are glyphosate (Roundups), lambda cyhalothrin (Karates), atrazine and simazine (Herbimixs) and azoxystrobin (priori Xtras) (Salvagni et al, 2011). Pesticides are known as a major concern in the aquatic environment because of their toxicity, persistence and tendency to accumulate in aquatic organisms (Joseph and Raj, 2010).…”

Section: Discussionmentioning

confidence: 99%

Oxidative stress and hypermethylation induced by exposure of Oreochromis niloticus to complex environmental mixtures of river water from Cubatão do Sul, Brazil

Fuzinatto

Flohr

Melegari

et al. 2015

Ecotoxicology and Environmental Safety

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Section: Discussionmentioning

confidence: 99%

Oxidative stress and hypermethylation induced by exposure of Oreochromis niloticus to complex environmental mixtures of river water from Cubatão do Sul, Brazil

Fuzinatto

Flohr

Melegari

et al. 2015

Ecotoxicology and Environmental Safety

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“…Oreochromis niloticus has been widely used for analysis of chromosomal damage in impacted environments (Hoshina et al, 2008;Soliman & Ibrahim, 2012;Salvagni, Ternus, & Fuentefria, 2011). The Micronuclei frequency found in O. niloticus erythrocytes from Riacho das Cachoeira dam is represented in Figure 3.…”

Section: Oreochromis Niloticus Mnmentioning

confidence: 99%

<b>Influence of natural radon and metal contamination on surface water quality from a Brazilian Semiarid Region

Dantas

Navoni

Ferreira

et al. 2017

Acta Sci. Biol. Sci.

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ABSTRACT. The Brazilian semiarid region presents some adverse environmental conditions for the settled population such as a restricted water availability and the presence of radon and metal natural sources that can contaminate the water reservoirs and consequently become a concern for human health. The present study evaluated the water quality of the Riacho das Cachoeiras Dam located in the urban area of Lajes Pintadas (state of Rio Grande do Norte, Brazil) as source for human consumption. An analysis of Physicochemical parameters, heavy metal content and Radon in water samples was performed along with the assessment of the water mutagenic potential through Micronucleus Test (MN) on Tradescantia pallida and Oreochromis niloticus. The content of metals in water for Al, Cd, and Ni were above water quality guidelines for human consumption. Moreover, high levels of Pb along with dissolved Radon were found. An acute and chronic mutagenic water capability was observed. These findings demonstrated that the water quality is unsuitable for human consumption due to the presence of high levels of contaminants mainly from geogenic origin and its deleterious effect on living systems.Keywords: radiation, lead, mutagenicity, micronucleus, geogenic contamination.Influência da contaminação natural pelo radônio e metais na qualidade das águas superficiais da Região Semiárida Brasileira RESUMO. A região semiárida brasileira apresenta condições ambientais adversas para população local, como a escassez na disponibilidade de água e a presença de fontes naturais de radônio e de metais que podem contaminar os reservatórios de água e, consequentemente, tornar-se um problema de saúde humana. O estudo avaliou a qualidade da água do Açude do Riacho das Cachoeiras localizado na área urbana de Lajes Pintadas (Rio Grande do Norte, Brasil) como fonte para o consumo humano. Foram realizadas análises físico-químicas, de conteúdo de metais e de radônio em amostras de água em conjunto com a avaliação do potencial mutagênico da água por meio do teste de micronúcleos (MN) em Tradescantia pallida e Oreochromis niloticus. Os metais Al, Cd, e Ni estavam acima das diretrizes de qualidade da água para o consumo humano. Além disso, foram encontrados altos níveis de Pb dissolvido, juntamente com o radônio. Observou-se um potencial de indução de efeito mutagênico nas amostras de água testadas, tanto na exposição aguda quanto na crônica. Estes resultados demonstram que a qualidade da água do Açude está imprópria para o consumo humano devido à presença de elevados níveis de contaminantes de origem geogênica, com capacidade de exercer efeito deletério sobre os organismos.

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“…It is metabolized in soybean through dealkylation and conjugation of the resulting chlorobenzyl moiety to form a glycoside (Elnaggar et al 1992). Clomazone did not produce any genotoxic effect in the Salmonella typhimurium reversion-Ames test (US EPA 2007) although it was positive in inducing micronucleus in erythrocytes from farming communities of fishes (Salvagni et al 2011) and also induced oxidative stress in human erythrocytes in vivo (Santi et al 2011).…”

Section: Introductionmentioning

confidence: 99%

HERBICIDE GENOTOXICITY REVEALED WITH THE SOMATIC WING SPOT ASSAY OF Drosophila melanogaster

Sortibrán

Flores-Loyola

Martínez-Martínez

et al. 2019

Rev. Int. Contam. Ambie.

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The genotoxicity of the herbicides clomazone, linuron and simazine was detected using the somatic wing spot assay of Drosophila melanogaster. For the evaluation of the mutagenic and recombinogenic activities induced by the herbicides two crosses were used: the standard cross (ST) which expresses basal levels of cytochrome P450 enzymes and the high bioactivation cross (HB) with overexpression of P450 genes conferring increased sensitivity to promutagens and procarcinogens. Third-instar larvae were exposed by chronic feeding (48 h) to three different concentrations of each herbicide. The frequencies of spots per individual in the treated series were compared to the negative concurrent control series (water or 5 % ethanol solution depending on the herbicide). Clomazone showed positive results for small and total spots in both the ST and the HB crosses. Linuron was positive at all concentrations tested for small and total spots in the ST cross while only positive for small and total spots at the highest concentration assayed in the HB cross. Simazine did not produce positive results in the ST cross while it was positive in the HB cross. The bifunctional cross-linking agent mitomycin C (MMC-0.15 mM) was used as positive control and produced as expected a significant increase of all types of spots in both crosses. In conclusion, the positive results were due to induced mutations and not by recombinogenic activity, furthermore the significant increase in the frequency of total spots was mainly due to the induction of small single spots. Palabras clave: clomazón, linurón, simacina, ensayo de mutación y recombinación somática RESUMEN La genotoxicidad de los herbicidas clomazón, linurón y simacina se detectó empleando el ensayo somático en alas de Drosophila melanogaster. Para la evaluación de la actividad mutagénica y recombinogénica inducida por los herbicidas se emplearon dos cruzas: la cruza estándar (ST) que expresa niveles basales de enzimas citocromo P450 y

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Assessment of the genotoxic impact of pesticides on farming communities in the countryside of Santa Catarina State, Brazil

Cited by 29 publications

References 30 publications

Oxidative stress and hypermethylation induced by exposure of Oreochromis niloticus to complex environmental mixtures of river water from Cubatão do Sul, Brazil

Oxidative stress and hypermethylation induced by exposure of Oreochromis niloticus to complex environmental mixtures of river water from Cubatão do Sul, Brazil

<b>Influence of natural radon and metal contamination on surface water quality from a Brazilian Semiarid Region

HERBICIDE GENOTOXICITY REVEALED WITH THE SOMATIC WING SPOT ASSAY OF Drosophila melanogaster

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