Synteny of human chromosomes 14 and 15 in the platyrrhines (Primates, Platyrrhini)

Gifalli-Iughetti, Cristiani; Koiffmann, Célia Priszkulnik

doi:10.1590/s1415-47572009005000069

Cited by 2 publications

(2 citation statements)

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“…This evidence is supported by what is shown in the other species here analyzed, where the 14/15 syntenic association is present and human probe 14 is split into two fragments. The different size of human synteny 14 (in association with synteny 15) in the species analyzed indicates that the fissions presumably occurred with different breakpoints and are consistent with the high level of rearrangements previously shown in other primate taxa [ 49 , 50 ]. Human probe 15 can also be found in a single block or split into two blocks in the analyzed taxa ( Table 1 ).…”

Section: Discussionsupporting

confidence: 84%

“…Human probe 15 can also be found in a single block or split into two blocks in the analyzed taxa ( Table 1 ). Thus, human chromosomes 14 and 15 have been subject to different chromosomal rearrangements involving different breakpoints, giving different fragments [ 49 , 50 , 51 ]. It would be useful in the future to verify the breakpoints of these syntenies in the Cercopithecini species using the BAC (bacterial artificial chromosomes) mapping approach, which can provide new insight into their chromosomal evolution [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

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Chromosome Painting in Cercopithecus petaurista (Schreber, 1774) Compared to Other Monkeys of the Cercopithecini Tribe (Catarrhini, Primates)

Milioto

Sineo

Dumas

2023

Life

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The Cercopithecini tribe includes terrestrial and arboreal clades whose relationships are controversial, with a high level of chromosome rearrangements. In order to provide new insights on the tribe’s phylogeny, chromosome painting, using the complete set of human syntenic probes, was performed in Cercopithecus petaurista, a representative species of the Cercopithecini tribe. The results show C. petaurista with a highly rearranged karyotype characterized by the fission of human chromosomes 1, 2, 3, 5, 6, 8, 11, and 12. These results compared with the literature data permit us to confirm the monophyly of the Cercopithecini tribe (fissions of chromosomes 5 and 6), as previously proposed by chromosomal and molecular data. Furthermore, we support the monophyly of the strictly arboreal Cercopithecus clade, previously proposed by the molecular approach, identifying chromosomal synapomorphies (fissions of chromosomes 1, 2, 3, 11, 12). We also add additional markers that can be useful for deciphering arboreal Cercopithecini phylogeny. For example, the fission of chromosome 8 is synapomorphy linking C. petaurista, C. erythrogaster, and C. nictitans among the arboreal species. Finally, a telomeric sequence probe was mapped on C. petaurista, showing only classic telomeric signals and giving no support to a previous hypothesis regarding a link between interspersed telomeric sequences in high rearranged genomes.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Chromosome Painting in Cercopithecus petaurista (Schreber, 1774) Compared to Other Monkeys of the Cercopithecini Tribe (Catarrhini, Primates)

Milioto

Sineo

Dumas

2023

Life

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The 14/15 association as a paradigmatic example of tracing karyotype evolution in New World monkeys

et al. 2015

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Fluorescence in situ hybridization (FISH), especially chromosome painting, has been extensively exploited in the phylogenetic reconstruction of primate evolution. Although chromosome painting is a key method to map translocations, it is not effective in detecting chromosome inversions, which may be up to four times more frequent than other chromosomal rearrangements. BAC-FISH instead can economically delineate marker order and reveal intrachromosomal rearrangements. However, up to now, BAC-FISH was rarely used to study the chromosomes of New World monkeys partly due to technical difficulties. In this paper, we used BAC-FISH to disentangle the complex evolutionary history of the ancestral 14/15 association in NWMs, beginning from the squirrel monkey (Saimiri boliviensis). To improve the hybridization efficiency of BAC-FISH in NWMs, we "translated" the human BACs into Callithrix jacchus (CJA) BACs, which yielded much higher hybridization efficiencies on other NWM species than human BACs. Our results disclosed 14 synteny blocks in squirrel monkeys, 7 more than with chromosome painting. We then applied a subset of CJA BACs on six other NWM species. The comparison of the hybridization pattern of these species contained phylogenetic information to discriminate evolutionary relationships. Notably Aotus was found to share an inversion with Callithrix, thus definitely assigning the genus Aotus to Cebidae. The present study can be seen as a paradigmatic approach to investigate the phylogenetics of NWMs by molecular cytogenetics.

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Synteny of human chromosomes 14 and 15 in the platyrrhines (Primates, Platyrrhini)

Cited by 2 publications

References 32 publications

Chromosome Painting in Cercopithecus petaurista (Schreber, 1774) Compared to Other Monkeys of the Cercopithecini Tribe (Catarrhini, Primates)

Chromosome Painting in Cercopithecus petaurista (Schreber, 1774) Compared to Other Monkeys of the Cercopithecini Tribe (Catarrhini, Primates)

The 14/15 association as a paradigmatic example of tracing karyotype evolution in New World monkeys

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