Analysis of restriction fragment length polymorphism in the kappa-casein gene related to weight expected progeny difference in Nellore cattle

Biase, Fernando H.; Garnero, Analía Del Valle; Bezerra, Luiz Antônio Framartino; Rosa, A.J.M; Lôbo, Raysildo Barbosa; Martelli, Lúcia Regina

doi:10.1590/s1415-47572005000100014

Cited by 4 publications

(4 citation statements)

References 14 publications

(24 reference statements)

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“…Similar results were reported by Silva and Del Lama (1997) who analyzed protein profiles of milk samples from 205 animals of the Guzerat breed, and found a frequency of 0.19 for the variant B. Biase et al (2005) genotyped 408 Nellore animals and found a frequency of 0.09 for the B allele, while Silva and Del Lama (1997) found a frequency of 0.03 in this breed. In the present study, a much higher frequency was reported for the B allele in the Nellore breed (0.18) compared to previous reports.…”

Section: Allele and Genotype Frequenciessupporting

confidence: 85%

Genetic polymorphism of the kappa-casein gene in Brazilian cattle

Azevedo

Nascimento²,

Steinberg³

et al. 2008

Genet. Mol. Res.

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ABSTRACT. Frequencies of κ-casein gene alleles were determined in 1316 animals from the Brazilian Bos indicus genetic groups (Sindhi cows, Gyr sires, Gyr cows, Guzerat sires, Guzerat cows, Nellore sires, and Gyr x Holstein crossbreds) by means of polymerase chain reaction-restriction fragment length polymorphism analysis using two independent restriction nucleases (Hinf I and HaeIII). The genotyping of κ-casein alleles (A and B) is of practical importance, since the B allele is found to correlate with commercially valuable parameters of cheese yielding efficiency. The frequencies of the B allele of κ-casein among breeds ranged from 0.01 to 0.30. The Sindhi breed had the highest frequency for the B allele (0.30), while the frequencies of this allele in other breeds ranged from 0.01 to 0.18. A wide variation in the B allele frequency among B. indicus breeds was found suggesting that molecular selection for animals carrying the B allele could impact breeding programs for dairy production.

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Section: Allele and Genotype Frequenciessupporting

confidence: 85%

Genetic polymorphism of the kappa-casein gene in Brazilian cattle

Azevedo

Nascimento²,

Steinberg³

et al. 2008

Genet. Mol. Res.

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“…However, high frequency of A allele and AA genotype at k-CN was also observed in Brazilian zebu Gyr and Nellore cattle (Kemenes et al 1999). Biase et al (2005) found an allele frequency of above 0.91 for Allele A in Brazilian Nellore cattle. Similarly, Golijow et al (1999) reported high frequency of A allele in Argentine Creole (AC) and Argentine commercial Holstein (AH) cattle).…”

Section: Resultsmentioning

confidence: 80%

“…Similarly, Golijow et al (1999) reported high frequency of A allele in Argentine Creole (AC) and Argentine commercial Holstein (AH) cattle). The major reason for high frequency of A alleles of k-CN in Brazilian zebu cattle was thought to be due to intensive selection for weight gain and meat production (Biase et al 2005). Conversely, the Indian native cattle breeds like Ladakhi cattle are known to be evolved naturally with almost no artificial selection pressure for productive traits, showed comparatively lower frequency of A allele and AA genotype.…”

Section: Resultsmentioning

confidence: 99%

Analysis of allelic pattern across milk trait genes in native cattle adapted to high altitude region of Leh-Ladakh

Sodhi

Verma

Bharti

et al. 2021

Indian J of Anim Sci

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Ladakhi, the native cattle from Ladakh region of India have developed over the years under natural selection and can survive well at extreme climatic conditions, viz. high altitude, huge barren lands, low temperature (â‰¤â€“20Â°C) and hypoxic conditions. Even at extreme survival conditions, this cattle provides around 2â€“5 kg of milk. This highly evolved germplasm might possess unique alleles or combinations of alleles, hence attempt was made to study the frequency of allelic variants at important candidate gene loci affecting dairy traits. The observed distribution pattern of allele frequencies were different from taurine but in accordance with other Indian native cattle breeds indicating maintenance of indicine characteristics and near absence of taurine influence/introgression effect on this naturally evolved germplasm. Further, variant E at Îº-CN locus and two novel variants at BTN-3 loci were also observed. The present findings helped to understand the unique Ladakhi cattle population with respect to polymorphism and distribution of various alleles in candidate genes related to milk traits.

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“…Lara et al 2002 suggest that k-casein variants could have an important role in the growth and maternal effects in beef breeds. However, Biase et al 2005 indicate that a kappa-casein polymorphism did not influence weight-gain in Brazilian Nellore herds, although they found differences in the frequency of the A and B alleles, with the A allele observed most frequently in this beef breed. Similar results were reported by Curi et al 2005 in Nellore, Canchim and a crossbreed (Simmental x Nellore, Angus x Nellore) cattle.…”

Section: Fig 2 Confirmation Of Pcr-rflp For Variants E and H Of K-camentioning

confidence: 81%

Convenient genotyping of nine bovine K-casein variants

Contreras¹,

Jaramillo²,

Parra‐Bracamonte³

et al. 2011

Electro Journal of Biotech

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K-casein gene polymorphisms are of major importance in the dairy industry due to their association with different quality and productive traits (i.e., milk protein). Several methods for genotyping this gene have been proposed; however, none are focused on the simultaneous discrimination of nine K-casein variants. A strategy based on PCR-RFLP was designed to characterize nine K-casein variants (A, B, C, E, F 2 , G, H, I and J) and used to genotype three cattle populations: Gyrholando (3/8 Gyr x 5/8 Holstein), Charolais and Carora. The B variant was the most frequent in the Charolais and Carora breeds, with allelic frequencies of 0.60 and 0.59, respectively. In the Gyrholando breed, four variants were found, with the A variant being the most frequent and E and H the least. The genotyping strategy was effective in detection and differentiation of K-casein variants, and it is proposed for use in laboratories with minimal molecular biology equipment for genotyping and evaluation of the phenotypic effects of nine K-casein variants on milk production and quality.

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Analysis of restriction fragment length polymorphism in the kappa-casein gene related to weight expected progeny difference in Nellore cattle

Cited by 4 publications

References 14 publications

Genetic polymorphism of the kappa-casein gene in Brazilian cattle

Genetic polymorphism of the kappa-casein gene in Brazilian cattle

Analysis of allelic pattern across milk trait genes in native cattle adapted to high altitude region of Leh-Ladakh

Convenient genotyping of nine bovine K-casein variants

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