Evaluation of the mutagenic potential of Cochlospermum regium in Drosophila melanogaster male germ cells

Nunes, Wanderlene Blanco; Carvalho, Salvador de

doi:10.1590/s1415-47572003000400020

Cited by 13 publications

(8 citation statements)

References 16 publications

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“…As well as illustrating the number of medicinal uses per species, Figure 3 also shows the number of pharmacological studies conducted which have tested the bioactivity of many of the species, including one species, Cochlospermum gillivraei Benth., that doesn't have any documented medicinal uses. Many of these pharmacological studies found extracts from tested species to be potentially effective and safe medicines through in vitro and/or in vivo laboratory studies [42,48,[50][51][52][59][60][61]72,. Cochlospermum tinctorium, from West Africa, was found to be the species with the highest number of medicinal uses and has been the focus of many bioscreening studies (Figures 3 and 7).…”

Section: Resultsmentioning

confidence: 99%

Comparing Medicinal Uses of Cochlospermaceae throughout Its Geographic Range with Insights from Molecular Phylogenetics

Johnson-Fulton

Watson

2018

Diversity

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Species of the Cochlospermaceae, a small mostly pantropical plant family, were evaluated at a continental scale for medicinal uses in traditional medicine. This ethnobotanical information was placed in a phylogenetic framework to make informed predictions in the search for new medicines and bioactive compounds. Medicinal plant-use data were mapped onto a molecular phylogeny based on DNA sequences of nuclear and chloroplast markers. Associations of medicinal uses among closely related species occurring in different geographic regions and among diverse cultures were evaluated. The most common medicinal uses for these species are those used to treat skin ailments, gastro-intestinal problems, malaria, and liver issues. The plant species with the most numerous uses is Cochlospermum tinctorium, which occurs primarily in West Africa. Closely related species being used by cultural groups in different geographic regions to treat the same illnesses suggests the presence of bioactive compounds with potential biomedical value, since they may represent independent discoveries of similar medicinally-active compounds. This leads to the speculation that those closely related species not currently being used to treat these ailments may also contain identical or similar medicinally-active compounds and are worthy of laboratory investigations.

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Section: Resultsmentioning

confidence: 99%

Comparing Medicinal Uses of Cochlospermaceae throughout Its Geographic Range with Insights from Molecular Phylogenetics

Johnson-Fulton

Watson

2018

Diversity

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“…The spots observed were classified according to their size, position in the wing, and type (single, twin) for evaluation and statistical analysis Würgler, 1988, 1995). Nunes and Carvalho (2003) evaluated the mutagenic potential of Cochlospermum regium in D. melanogaster germinative cells using the ring-X-loss test and reported a 1.13% loss of the ring-X-chromosome at the dose of 0.013 g/mL in Brood 3. A similar result (1.15%) was found in the present study for Brood 2 using 0.085 g/mL D. furfuracea infusion and both studies presented negative results for mutagenesis.…”

Section: Smart/wing Testmentioning

confidence: 99%

Modulatory effects of Duguetia furfuracea (A. St. Hil) Benth. and Hook. f. in Drosophila melanogaster somatic and germinative cells

Coelho¹,

Felício²,

Miranda³

et al. 2011

Genet. Mol. Res.

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“…In relation to genotoxicity study, Nunes and Carvalho (2003) did not detect genotoxic activity of the C. regium roots aqueous extract in Drosophila melanogaster Meigen, 1830 germinative cells but this extract has provoked mutations and recombinations in somatic cells. Recent investigations in our laboratory have indicated that the i.p.…”

Section: Introductionmentioning

confidence: 82%

Absence of antimutagenicity of Cochlospermum regium (Mart. and Schr.) Pilger 1924 by micronucleus test in mice

et al. 2008

Braz. J. Biol.

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Cochlospermum regium (Mart. and Schr.) Pilger, popularly known as "algodãozinho do campo", is a medicinal plant that grows in the Cerrado of Brazil. This plant has been used in traditional medicine against various diseases such as leucorrhoea, gastritis and ulcers. It has also been effective in treating skin problems like pimples, boils and blotches. In the present study, the in vivo antimutagenicity of aqueous extract of C. regium was evaluated. The Micronucleus Test was performed in polychromatic erythrocytes from Swiss male mice treated with one of the four doses of extract of the plant (19, 38, 76 and 114 mg.kg -1 body weight), administered by intraperitonial injection (i.p.) simultaneously with cyclophosphamide (24 mg.kg -1 b.w.) or mitomycin C (4 mg.kg -1 b.w.). The cytotoxicity was evaluated by polychromatic and normochromatic erythrocytes ratio (PCE/NCE). The results showed no significant reduction of the micronucleated polychromatic erythrocytes frequency (P > 0.05). In conclusion, the data indicate that C. regium roots aqueous extract, for the conditions used, did not exhibit the antimutagenic effect.Keywords: Cochlospermum regium, antimutagenicity, micronucleus, mice. Ausência de antimutagenicidade do Cochlospermum regium pelo Teste do Micronúcleo em camundongos ResumoCochlospermum regium (Mart. & Schr.) Pilger, conhecido popularmente como "algodãozinho-do-campo", é uma planta medicinal que cresce no Cerrado brasileiro. Esta planta tem sido utilizada na medicina tradicional contra várias doenças como leucorréia, gastrites e úlceras. Esta também tem se mostrado efetiva no tratamento de doenças de pele como espinhas, furúnculos e manchas. No presente estudo, foi avaliada a antimutagenicidade do extrato aquoso de C. regium pelo Teste do Micronúcleo in vivo. Este ensaio foi realizado em eritrócitos policromáticos de camundongos machos Swiss tratados com quatro concentrações diferentes do extrato da planta (19, 38, 76 e 114 mg.kg -1 por peso corpóreo), administrado por injeção intraperitonial (i.p.) simultaneamente com ciclofosfamida (24 mg.kg -1 p.c.) ou mitomicina C (4 mg.kg -1 p.c.). A citotoxicidade foi avaliada pela razão eritrócitos policromáticos e normocromáticos (PCE/NCE). Os resultados obtidos não mostraram redução significativa da freqüência de eritrócitos policromáticos micronucleados (P > 0,05). Em conclusão, os resultados indicam que o extrato aquoso de raiz de C. regium, para as condições utilizadas, não exibiu efeito antimutagênico.Palavras-chave: Cochlospermum regium, antimutagenicidade, micronúcleo, camundongos.

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Evaluation of the mutagenic potential of Cochlospermum regium in Drosophila melanogaster male germ cells

Cited by 13 publications

References 16 publications

Comparing Medicinal Uses of Cochlospermaceae throughout Its Geographic Range with Insights from Molecular Phylogenetics

Comparing Medicinal Uses of Cochlospermaceae throughout Its Geographic Range with Insights from Molecular Phylogenetics

Modulatory effects of Duguetia furfuracea (A. St. Hil) Benth. and Hook. f. in Drosophila melanogaster somatic and germinative cells

Absence of antimutagenicity of Cochlospermum regium (Mart. and Schr.) Pilger 1924 by micronucleus test in mice

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