&lt;FONT FACE=Symbol&gt;k&lt;/FONT&gt;-Casein, &lt;FONT FACE=Symbol&gt;b&lt;/FONT&gt;-lactoglobulin and growth hormone allele frequencies and genetic distances in Nelore, Gyr, Guzerá, Caracu, Charolais, Canchim and Santa Gertrudis cattle

Kemenes, Paola Augusta; Regitano, Luciana Correia de Almeida; Rosa, A. do N.; Packer, Irineu Umberto; Razook, Alexander George; Figueiredo, Leopoldo Andrade de; Silva, Nirlei Aparecida; Etchegaray, M A L; Coutinho, Luiz Lehmann

doi:10.1590/s1415-47571999000400012

Cited by 50 publications

(50 citation statements)

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“…In the present study, a low frequency of allele A was observed in the Nelore group compared to the results reported by Rosa (1997), Kemenes et al (1999) and , who found frequencies of 0. 41, 0.40 and 0.24, respectively.…”

contrasting

confidence: 55%

“…found a frequency of 0.67 for the A allele in animals of the Canchim breed. In addition, these and other studies have shown higher frequencies of allele A compared to allele B in both taurine (Ron et al, 1994;Moody et al, 1996;Vasconcellos et al, 2003) and Zebu breeds (Mitra et al, 1998;Kemenes et al, 1999;, regardless of whether dairy or beef cattle were studied. This finding indicates that differences in the selection criteria for milk or meat production in these breeds do not favor different alleles of this polymorphism.…”

mentioning

confidence: 54%

“…Kemenes et al (1999) and observed frequencies of 0.91 and 0.94, respectively, in Nelore animals. found a frequency of 0.67 for the A allele in animals of the Canchim breed.…”

mentioning

confidence: 76%

“…Regitano et al (1999Regitano et al ( , 2000 and Vasconcellos et al (2003) observed frequencies of 0.40, 0.46 and 0.17 for allele A in Canchim, Simmental and Angus breeds, respectively. In other studies, the frequency of the A allele of the β-lactoglobulin polymorphism was 0.43 and 0.39 in the dairy taurine breeds Holstein and Brown Swiss, respectively (Van Eenennaan and Medrano, 1991), and 0.37 in the Zebu GirGir breed (Kemenes et al, 1999). The allele frequencies of this polymorphism are heterogeneous among breeds and seem to be independent of origin (Zebu or taurine) and type of production (meat or milk).…”

mentioning

confidence: 78%

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Effects of CSN3 and LGB gene polymorphisms on production traits in beef cattle

et al. 2005

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The objective of the present study was to estimate the allele and genotype frequencies of the CSN3/HinfI and LGB/HaeIII gene polymorphisms in beef cattle belonging to different genetic groups, and to determine the effects of these polymorphisms on growth and carcass traits in these animals, which are submitted to an intensive production model. Genotyping was performed on 79 Nelore, 30 Canchim (5/8 Charolais + 3/8 Zebu) and 275 crossbred cattle originating from the crosses of Simmental (n = 30) and Angus (n = 245) sires with Nelore females. Body weight, weight gain, dressing percentage, longissimus dorsi area and backfat thickness were fitted using the GLM procedure, and least square means of the genotypes were compared by the F test. The results showed that the CSN3/HinfI and LGB/HaeIII polymorphisms did not have any effect on growth or carcass traits (p > 0.05).Key words: beef cattle, polymorphisms, candidate gene, growth, carcass. "Super-young" steers are animals finished on feedlot immediately after weaning and slaughtered as 13 montholds at the most, weighing at least 450 kg. These animals should also have backfat thickness above 3.0 mm, which, associated with the animals' youth, will guarantee the quality of meat and its by-products. This system takes advantage of maximum biological efficiency, which can basically be defined as live weight gain over energy intake. It provides an excellent model of intensive cattle rearing.The κ-casein (CSN3) and β-lactoglobulin (LGB) genes are expressed in milk and are important in the evaluation of the milk production potential and milk fat and protein percentage, indicating a maternal ability in beef cattle and therefore representing candidate genes for growth traits. In addition, these genes can also be associated with other loci that have a direct influence on growth. Polymorphisms of these genes have been associated with milk production and quality and weight gain until weaning in dairy cattle. However, the results of these studies are contradictory. On the other hand, the effects of milk protein polymorphisms on production traits in beef cattle have been little investigated. Moody et al. (1996) observed an effect of a κ-casein gene polymorphism on growth traits in Hereford beef cattle.The objectives of the present study were to estimate the allele and genotype frequencies of CSN3 and LGB gene polymorphisms in beef cattle belonging to different genetic groups and to determine the effects of these polymorphisms on production traits in these animals which are submitted to a "super-young" production model.For this purpose, blood was collected from 384 bulls belonging to four different genetic groups and differing in frame size, including 79 Nelore, 30 Canchim (5/8 Charolais + 3/8 Zebu) and 275 crossbred cattle originating from crosses of Simmental (n = 30) and Angus (n = 245) sires with Nelore females.Calves were weaned at 210 days of age using a creep-feeding system. At the beginning of the study, the animals were individually identified, treated against endoand ...

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contrasting

confidence: 55%

mentioning

confidence: 54%

“…Kemenes et al (1999) and observed frequencies of 0.91 and 0.94, respectively, in Nelore animals. found a frequency of 0.67 for the A allele in animals of the Canchim breed.…”

mentioning

confidence: 76%

mentioning

confidence: 78%

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Effects of CSN3 and LGB gene polymorphisms on production traits in beef cattle

et al. 2005

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“…The κ-casein allele A has been associated with lower milk fat and calcium amount and a lower milk pH (Kürbarsepp et al, 2005). However, allele B is rare in indicine breeds selected for milk production and has not been found in meat selection zebu herds (Kemenes et al, 1999;Azevedo et al, 2008). To date, no report on the effects of this polymorphism on milk coagulation properties in cheese production in indicine breeds have been published.…”

Section: Introductionmentioning

confidence: 99%

A new tetra-primer ARMS-PCR for genotyping bovine kappa-casein polymorphisms

Fonseca

Rosse²,

Demiranda³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. Kappa-casein (κ-casein) is one of the most abundant milk proteins. Its main function is to avoid the aggregation of casein micelles, keeping them, and therefore calcium phosphate, in pockets in solution. In bovines, a κ-casein functional polymorphism has been associated with fat, calcium, and protein milk contents and faster curd contraction in cheese production. Quicker curd contraction reduces the loss of milk solids, enhancing cheese yield. This polymorphism induces a double amino acid substitution (Thr136Ile and Ala148Asp). The polymorphism is normally detected by PCR-RFLP, which is a laborious method. An interesting methodological alternative is the tetra-primer amplification refractory mutation system PCR (tetra-primer ARMS-PCR). A tetraprimer ARMS-PCR for the detection of this κ-casein polymorphism has been described. However, specificity was not achieved, probably due to problems with primer design. We developed a new tetra-primer ARMS-PCR for the detection of the κ-casein polymorphism. This new method was validated in a double-blind test, by comparison with the results obtained for 50 Guzerá bulls formerly genotyped by PCR-RFLP. This new method achieved 100% sensitivity and specificity. We conclude that this method is a useful, cost-efficient alternative for the detection of functional κ-casein polymorphisms.

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Assessment of GH1, CAPN1 and CAST polymorphisms as markers of carcass and meat traits in Bos indicus and Bos taurus–Bos indicus cross beef cattle

et al. 2010

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The objective of this study was to investigate the effects of bovine GH1, CAPN1 and CAST gene polymorphisms on carcass and meat traits in Nellore and Nellore x Bos taurus beef cattle. Three hundred animals were genotyped for GH1/MspI (TC/G in intron 3), CAPN316 (AF_252504.2:g.5709C>G) and CAST/RsaI (AY_008267.1:g282C>G) and phenotyped for rib eye area, backfat thickness, intramuscular fat, shear force (SF), and myofibrillar fragmentation index (MFI). No significant associations were observed between the GH1/MspI and CAST/RsaI polymorphisms and phenotypes, although the relation between the CAST/RsaI genotypes and meat tenderness evaluated by MFI approached significant. The fact that the CAPN316 polymorphism did not show adequate segregation in Nellore cattle confirms the difficulty of using this marker in breeding programs of different Bos indicus breeds. However, the positive results of the association analysis obtained for Nellore x B. taurus crosses contributed to the validation of previous findings.

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<FONT FACE=Symbol>k</FONT>-Casein, <FONT FACE=Symbol>b</FONT>-lactoglobulin and growth hormone allele frequencies and genetic distances in Nelore, Gyr, Guzerá, Caracu, Charolais, Canchim and Santa Gertrudis cattle

Cited by 50 publications

References 9 publications

Effects of CSN3 and LGB gene polymorphisms on production traits in beef cattle

Effects of CSN3 and LGB gene polymorphisms on production traits in beef cattle

A new tetra-primer ARMS-PCR for genotyping bovine kappa-casein polymorphisms

Assessment of GH1, CAPN1 and CAST polymorphisms as markers of carcass and meat traits in Bos indicus and Bos taurus–Bos indicus cross beef cattle

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