Selection for breed-specific growth hormone and IGF-I alleles in a synthetic beef cattle cross, Canchim

Regitano, Luciana Correia de Almeida; Azevedo, João Lúcio; Vencovsky, Roland; Packer, Irineu Umberto; Barbosa, Pedro; Rosa, A.J.M; Silva, N.A; Etchegaray, M A L; Coutinho, Luiz Lehmann

doi:10.1590/s1415-47571999000400011

Cited by 16 publications

(15 citation statements)

References 13 publications

(11 reference statements)

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“…These authors observed a negative effect of substitution of allele A with allele B of the κ-casein polymorphism on EPD (Expected Progeny Difference) for birth weight, weaning weight and maternal milk production, indicating that the A allele is favorable to these traits. However, our results agree with those obtained by Regitano et al (1999) and Tambasco et al (2003), who did not observe any influence of this polymorphism on growth traits in Canchim beef cattle and F1 animals of Canchim x Nelore, Simmental x Nelore and Angus x Nelore crosses, respectively. According to Pomp et al (1994), these contradictions can be explained by differences in the linkage equilibrium between markers and quantitative traits loci in the various populations studied, or by different epistatic interactions between the genetic bases of these populations and quantitative trait loci.…”

supporting

confidence: 93%

“…Regitano et al (1999) did not observe allele variations between different generations of a Canchim herd and suggested that this polymorphism is not associated with phenotypic traits subjected to selection in this herd. Similarly, Tambasco et al (2003) did not observe an isolated influence of the LGB/HaeIII polymorphism on the growth traits of crossbred Canchim x Nelore, Simmental x Nelore and Angus x Nelore cattle.…”

mentioning

confidence: 69%

“…This variation in the results might be explained by different selection criteria applied to the herds, or by differences in the allele frequencies between base populations. Regitano et al (1999Regitano et al ( , 2000 and Vasconcellos et al (2003) observed frequencies of 0.40, 0.46 and 0.17 for allele A in Canchim, Simmental and Angus breeds, respectively. In other studies, the frequency of the A allele of the β-lactoglobulin polymorphism was 0.43 and 0.39 in the dairy taurine breeds Holstein and Brown Swiss, respectively (Van Eenennaan and Medrano, 1991), and 0.37 in the Zebu GirGir breed (Kemenes et al, 1999).…”

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confidence: 95%

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Effects of CSN3 and LGB gene polymorphisms on production traits in beef cattle

et al. 2005

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The objective of the present study was to estimate the allele and genotype frequencies of the CSN3/HinfI and LGB/HaeIII gene polymorphisms in beef cattle belonging to different genetic groups, and to determine the effects of these polymorphisms on growth and carcass traits in these animals, which are submitted to an intensive production model. Genotyping was performed on 79 Nelore, 30 Canchim (5/8 Charolais + 3/8 Zebu) and 275 crossbred cattle originating from the crosses of Simmental (n = 30) and Angus (n = 245) sires with Nelore females. Body weight, weight gain, dressing percentage, longissimus dorsi area and backfat thickness were fitted using the GLM procedure, and least square means of the genotypes were compared by the F test. The results showed that the CSN3/HinfI and LGB/HaeIII polymorphisms did not have any effect on growth or carcass traits (p > 0.05).Key words: beef cattle, polymorphisms, candidate gene, growth, carcass. "Super-young" steers are animals finished on feedlot immediately after weaning and slaughtered as 13 montholds at the most, weighing at least 450 kg. These animals should also have backfat thickness above 3.0 mm, which, associated with the animals' youth, will guarantee the quality of meat and its by-products. This system takes advantage of maximum biological efficiency, which can basically be defined as live weight gain over energy intake. It provides an excellent model of intensive cattle rearing.The κ-casein (CSN3) and β-lactoglobulin (LGB) genes are expressed in milk and are important in the evaluation of the milk production potential and milk fat and protein percentage, indicating a maternal ability in beef cattle and therefore representing candidate genes for growth traits. In addition, these genes can also be associated with other loci that have a direct influence on growth. Polymorphisms of these genes have been associated with milk production and quality and weight gain until weaning in dairy cattle. However, the results of these studies are contradictory. On the other hand, the effects of milk protein polymorphisms on production traits in beef cattle have been little investigated. Moody et al. (1996) observed an effect of a κ-casein gene polymorphism on growth traits in Hereford beef cattle.The objectives of the present study were to estimate the allele and genotype frequencies of CSN3 and LGB gene polymorphisms in beef cattle belonging to different genetic groups and to determine the effects of these polymorphisms on production traits in these animals which are submitted to a "super-young" production model.For this purpose, blood was collected from 384 bulls belonging to four different genetic groups and differing in frame size, including 79 Nelore, 30 Canchim (5/8 Charolais + 3/8 Zebu) and 275 crossbred cattle originating from crosses of Simmental (n = 30) and Angus (n = 245) sires with Nelore females.Calves were weaned at 210 days of age using a creep-feeding system. At the beginning of the study, the animals were individually identified, treated against endoand ...

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Effects of CSN3 and LGB gene polymorphisms on production traits in beef cattle

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“…h Yearling weight; *p < 0.05; **p < 0.01. generations of the traditional Canchim population (Regitano et al, 1999). Tambasco et al (2003) observed a positive association between genotype LV and daily body weight gain (BWG) from weaning to yearling in Bos taurus X Bos indicus crosses.…”

Section: Discussionmentioning

confidence: 99%

“…Evidence of selection effects on allele frequencies at these two loci was found in the traditional lineage of Canchim (Regitano et al, 1999). The objective of the present study was to evaluate the influence of the GH and IGF-1 genotypes on growth traits in Canchim cattle.…”

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confidence: 97%

Association of GH and IGF-1 polymorphisms with growth traits in a synthetic beef cattle breed

et al. 2005

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The Canchim beef cattle (5/8 Charolais + 3/8 Zebu) has been selected for meat production in Brazil since late 1950. In the present work the effects of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) polymorphisms were investigated in 688 animals born between 1998 and 2000. These animals belonged to two genetic groups, i.e., traditional and new lineages. Genotype effects on expected breeding values for birth weight (BW), weaning weight (WW) and yearling weight (YW) were investigated by the least square method. Significant effects were found for GH genotype on YW (p ≤ 0.05), with positive effects associated with the LV (leucine/valine) genotype. For IGF-1 genotypes, significant effects were found on BW (p ≤ 0.01) and YW (p ≤ 0.01). Average substitution effects for IGF-1 alleles estimated by regression analysis suggested a positive effect of the IGF-1 225 bp allele on BW and of the 229 bp allele on YW.

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Effect of IGF1, GH, and PIT1 markers on the genetic parameters of growth and reproduction traits in Canchim cattle

et al. 2014

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The availability of dense genomic information has increased genome-wide association studies for the bovine species; however research to assess the effect of single genes on production traits is still important to elucidate the genes functions. On this study the association of IGF1, GH, and PIT1 markers with growth and reproductive traits (birth weight, weaning weight, weight at 12 and 18 months of age, preweaning average daily weight gain, age and weight at first calving, and scrotal circumference at 12 and 18 months of age) were assessed by means of the variance component approach. The phenotypes were adjusted and then analyzed under two animal models, one which considered the polygenic and genotype (IGF1, GH or PIT1 markers) effects (Model 1), and the other which considers only the polygenic effect (Model 2). When the likelihood ratio test and the Bonferroni correction was applied at 5 % significance level, the genetic markers for the IGF1, GH, and PIT1 genes did not influence significantly the traits (p > 0.002). However, evidence of association of IGF1 with birth weight (p = 0.06) and GH with weight at first calving (p = 0.03) and with weight at 12 months of age (p = 0.08) was observed. In conclusion we could not confirm the associations between IGF1, GH, and PIT1 and growth traits that were previously reported in Canchim cattle, and no association was observed between these genes and reproductive traits. Future studies involving functional markers of IGF1, GH and PIT1 genes may help to clarify the role of these genes in growth and reproductive processes.

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Selection for breed-specific growth hormone and IGF-I alleles in a synthetic beef cattle cross, Canchim

Cited by 16 publications

References 13 publications

Effects of CSN3 and LGB gene polymorphisms on production traits in beef cattle

Effects of CSN3 and LGB gene polymorphisms on production traits in beef cattle

Association of GH and IGF-1 polymorphisms with growth traits in a synthetic beef cattle breed

Effect of IGF1, GH, and PIT1 markers on the genetic parameters of growth and reproduction traits in Canchim cattle

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