Osteosarcoma in dogs: clinical-morphological study and prognostic correlation

Cavalcanti, Josemara Neves; Amstalden, Eliane Maria Ingrid; Guerra, José Luiz; Magna, Luís Carlos

doi:10.1590/s1413-95962004000500002

Cited by 26 publications

(35 citation statements)

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“…OSA cases in bitches tend to be higher when compared to male dogs. However, some authors establish some differences related to neoplasia kind and gender: males suffer more from appendiceal manifestation, and females from axial type [7,22,[29][30][31].…”

Section: Resultsmentioning

confidence: 99%

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Retrospective Study of 33 Dogs Diagnosed with Osteosarcoma (OSA) by Fine Needle Aspiration Cytology (FNAC) at FMVZ Vet Hospital, UNESP-Botucatu, SP

Wilmsen

Tremori

Rocha

2016

ARRB

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Aim of Study:Evaluate cases of dogs with osteosarcoma, when diagnoses using FNAC. Study Design: A retrospective study, from archive at Veterinary Hospital, selected 33 dogs of different races, 23 females (69.6%) and 10 males (30.3%) were addressed, the age of tested dogs ranged from 1 to 15 years, with diagnoses of osteosarcoma using FNAC. These animals are classified according to localization of tumor, cytopathology evaluation and radiography exam. Results: In this study, a general OSA prevalence on appendicular skeleton of 90.9% (30), being humerus and axial skeleton 9.1% (3). Likewise, the highest age incidence ranged from 6 to 15 years (78.7%). 33 of 24 animals (72.7%) had tumor complications in forelimbs discriminated from high to low incidence: 17 (51.5%) left forelimbs (LFL,) and 7 (27.3%) right forelimbs (RFL). Cancer signs also appeared in axial skeleton of 2 individuals (6.5%), and paranasal sinus of another Wilmsen et al.; ARRB, 9(1): 1-8, 2016; Article no.ARRB.22707 2 (3.2%). Cytoplasmic and nuclear characteristics showed atypical mitosis in 31 (93.9%), and multinucleated cells in 33 (100%) on evaluated specimens. Conclusion: The use of FNAC demonstrated to be a simple, quick, efficient, minimally invasive, and inexpensive diagnostic tool. Original Research Article

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Section: Resultsmentioning

confidence: 99%

“…15 of 33 animals with OSA in humerus, 11 (33.3%) belonged to Rottweiller breed. Some races are more susceptible than others to suffer from humeral neoplasia, as Rottweiller already is [22,29].…”

Section: Fig 2 Conventional Radiography Of Pelvic Limb With Swellinmentioning

confidence: 99%

Retrospective Study of 33 Dogs Diagnosed with Osteosarcoma (OSA) by Fine Needle Aspiration Cytology (FNAC) at FMVZ Vet Hospital, UNESP-Botucatu, SP

Wilmsen

Tremori

Rocha

2016

ARRB

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“…The tumor caused difficulty in defecation and urination due to the pelvic occupation by the mass. Cavalcanti et al (2004) reported about the predominance of osteosarcoma among canine females. In spite of these findings, a male predisposition has been reported by other authors, and neutering or spaying, regardless of gender, may increase the risk of developing appendicular osteosarcoma (Ru et al, 1998).…”

Section: Resultsmentioning

confidence: 99%

Pelvic osteosarcoma ressection in a bitch: case report

Rodrigues

Faraco

Oliveira

et al. 2009

Arq. Bras. Med. Vet. Zootec.

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An osteosarcoma involving the pelvis was diagnosed in a 9-year-old neutered Labrador bitch. The clinical signs manifested by the patient before surgical removal of the tumor included urinary difficulty, dyschezia, and inconstant non-weight-bearing on the hindlimbs. These signs were linked to the localization of the tumor, which was identified as a firm and painful mass of the size of an orange in the caudal abdomen. The favorable short term clinical results after surgery and carboplatin chemotherapy showed that the association of these approaches can be employed to manage discomfort inflicted by tumor and, therefore improve the quality of life of patient of bone cancer.

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“…Em machos, a incidência é maior do que em fêmeas, entretanto, o osteossarcoma no esqueleto axial acomete mais as fêmeas do que os machos [3,8,14,15]. Estudos verificaram que de 50 animais com osteossarcoma, 31 (62%) eram fêmeas, embora não tenha sido realizada uma associação entre sexo e local da lesão [2]. Neste aspecto, houve discordância com a literatura consultada, pois as quatro fêmeas com osteossarcoma possuíam lesão neoplásica em um dos membros, embora a maior parte dos cães deste estudo (oito) tenha sido macho.…”

Section: Discussionunclassified

“…O principal sinal clínico do cão com osteossarcoma apendicular é a claudicação; no entanto, em lesões axiais é encontrado aumento de volume e dor à palpação. Em casos avançados, podese associar dificuldade respiratória com metástase pulmonar [2,16].…”

Section: Introductionunclassified

Estudo clínico de osteossarcoma canino

Teixeira

Martins

Fighera

et al. 2018

Acta Scientiae. Vet.

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Background:The canine osteosarcoma is characterized by being an aggressive bone tumor that affects mainly large dogs, middle-aged and male, accounting for 80-85% of bone tumors and 5-6% of all tumors. The risk of developing this tumor is, on average, 125 times greater in dogs weighing over 36 kg than in dogs weighing less than 9 kg. This cancer develops more frequently in the appendicular skeleton (75%), preferably the bones of the forelimbs, where approximately 60% of body weight are sustained. The canine osteosarcoma is very similar to human, in which the metaphyseal region of long bones is the most affected, causing lameness and swelling of the affected limb. The diagnosis is made from epidemiological data, history of the animal, X-rays and laboratory tests such as cytology fine-needle aspiration (FNAC) and measurement of the enzyme alkaline phosphatase (ALP). The staging of the disease becomes a major method for the treatment, whereas primary bone tumors are highly complex and end up interfering with the animal organism in whole. The objective of this study is to report a clinical study of 12 dogs with osteosarcoma, showing the procedures performed from diagnosis to treatment. Material, Methods and Results: Dogs were assisted at the Clinic of Small Animals VUH -UFSM and after the clinical examination were referred to the Department of Radiology. After the radiographic study, blood samples for biochemical and material for cytological analysis of the tumor were collected. After the confirmation of the neoplasm, the physician who prescribed the treatment, depending on the case, the accession to it was left to the owner. In this study, we observed the development of osteosarcoma in dogs from two to 14 years old. Furthermore, in 10 animals (83.3%) the tumor was located in one of the members and nine of these (75%) affected forelimbs. Still, eight dogs (66.7%) were males. The animals weighed on average, 30 kg and five were crossbreeds. Eight dogs (66.7%) had an elevation in enzyme ALP. In this study, five dogs (41%) received no treatment, four (33.3%) were killed and three (25.7%) had the treatment as prescribed by the clinician. Three of the dogs treated survived for a few weeks and two of those who received appropriate treatment survived more than a year. Discussion: The clinical and epidemiological findings of this study corroborate the literature, making them increasingly used in the auxiliary tests cited. For a proper diagnosis it is necessary for the veterinary practitioner to know which tests to determine use. Approximately 98% of the patients have micrometastases at diagnosis, however, only 5% of dogs with osteosarcoma have radiographic evidence of pulmonary metastasis. These will only cause clinical signs in advanced stages, leading the majority of dogs to euthanasia. Moreover, the appearance of bone thinning and explosion in the limb are strong indications of osteosarcoma. The FNAC is one of the main tests for diagnosing neoplastic, because the laboratory technician can visualize the tumor cells in prolif...

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Osteosarcoma in dogs: clinical-morphological study and prognostic correlation

Cited by 26 publications

References 0 publications

Retrospective Study of 33 Dogs Diagnosed with Osteosarcoma (OSA) by Fine Needle Aspiration Cytology (FNAC) at FMVZ Vet Hospital, UNESP-Botucatu, SP

Retrospective Study of 33 Dogs Diagnosed with Osteosarcoma (OSA) by Fine Needle Aspiration Cytology (FNAC) at FMVZ Vet Hospital, UNESP-Botucatu, SP

Pelvic osteosarcoma ressection in a bitch: case report

Estudo clínico de osteossarcoma canino

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