Syzygium cumini and the regeneration of insulin positive cells from the pancreatic duct

Schossler, Deila Rosély; Mazzanti, Cinthia M.; Luz, Sônia Cristina Almeida da; Filappi, Andreane; Prestes, Danívia; Silveira, Aron Ferreira da; Cecim, Marcelo

doi:10.1590/s1413-95962004000400003

Cited by 28 publications

(18 citation statements)

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“…An immunohistochemical staining study revealed positive staining for insulin in epithelia of the pancreatic duct and in cells around the duct in diabetic rats treated with aqueous extract of S. cumini bark at a dose of 1 g kg −1 BW for 30 days. This effect was not seen in control groups, suggesting the possibility that S. cumini can stimulate β cell regeneration by proliferation of its precursor cells in the pancreatic duct, since practically all its β cells were destroyed by alloxan …”

Section: Pharmacologymentioning

confidence: 89%

“…This effect was not seen in control groups, suggesting the possibility that S. cumini can stimulate β cell regeneration by proliferation of its precursor cells in the pancreatic duct, since practically all its β cells were destroyed by alloxan. 35 The methanolic leaf extract of S. cumini was assessed for its lipogenic, antilipolytic and glucose uptake activities. It was able to induce lipogenesis, inhibit epinephrine-induced lipolysis and enhance insulin-mediated glucose uptake in primary adipocytes at a dose range of (0.1-10) × 10 −3 g L −1 , suggesting insulin-like activity in S. cumini leaves.…”

Section: Introductionmentioning

confidence: 99%

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Pharmacological potentials of Syzygium cumini: a review

Srivastava

Chandra

2013

J Sci Food Agric

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In the last few years there has been an exponential growth in the field of herbal medicine, and these drugs are gaining popularity in both developing and developed countries because of their natural origin and lesser side effects. Syzygium cumini (syn. Eugenia jambolana, Syzygium jambolana, Eugenia cumini, Syzygium jambos), commonly known as jamun in India, is an evergreen tree distributed throughout the Indian subcontinent, Southeast Asia and East Africa. It is mainly utilised as a fruit producer and for its timber. Medicinally, the fruit is reported to have antidiabetic, antihyperlipidaemic, antioxidant, antiulcer, hepatoprotective, antiallergic, antiarthritic, antimicrobial, anti-inflammatory, antifertility, antipyretic, antiplaque, radioprotective, neuropsychopharmacological, nephroprotective and antidiarrhoeal activities. Among these beneficial physiological effects, the antidiabetic property of S. cumini has the most promising nutraceutical value. The health-beneficial effects of S. cumini are mainly attributed to various phytoconstituents such as tannins, alkaloids, steroids, flavonoids, terpenoids, fatty acids, phenols, minerals, carbohydrates and vitamins present in the fruit. This review paper presents an overview of experimental evidence for the pharmacological potential of S. cumini.

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Section: Pharmacologymentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Pharmacological potentials of Syzygium cumini: a review

Srivastava

Chandra

2013

J Sci Food Agric

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“…Feeding Jamun has also been shown to enhance the levels of serum insulin levels in both normoglycemic and diabetic rats (Achrekar et al, 1991;Chaturvedi et al, 2007;Panda et al, 2009;Ravi et al, 2004c;Sharma et al, 2006Sharma et al, , 2003, to protect pancreatic β-cells (Ravi et al, 2004d), stimulate synthesis of insulin from the residual beta cells (Grover et al 2000;Ravi et al 2004d;Sharma et al 2006;Sridhar et al 2005), inhibit insulinase in the liver and kidney and to trigger the development of insulin positive cells from the epithelial cells of the pancreatic duct (Helmstädter 2008;Schossler et al 2004).…”

Section: Antidiabetic Activitiesmentioning

confidence: 99%

Phytochemistry, traditional uses and pharmacology of Eugenia jambolana Lam. (black plum): A review

Baliga

Bhat²,

Baliga

et al. 2011

Food Research International

142

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“…Syzygium cumini (madan, Sinhala) is a tropical tree (Myrtaceae) of which the bark has been widely used in Ayurveda and Indian folk medicine for the treatment of DM [7]. Diabetic rats treated with S. cumini bark had shown significant decrease in blood glucose [8] and positive insulin staining in the epithelia cells of the pancreatic duct [9]. Further, the decoction from the bark extract as used in Ayurveda medicine and a ready to serve (RTS) drink prepared from the decoction had high antiglycation and antioxidant potential [10, 11].…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic Compounds in Syzygium cumini Decoction and Ready to Serve Herbal Drink

Perera

Ekanayake

Ranaweera

2017

Evidence-Based Complementary and Alternative Medicine

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Herbal beverages with desirable sensory attributes are an ideal way to offer consumers with phytochemicals having specific health promoting functionalities. Syzygium cumini bark decoction is used in treating diabetes mellitus in Ayurveda medicine. This work attempted to prove the presence of antidiabetic compounds in the S. cumini decoction and the ready to serve (RTS) herbal drink developed using the decoction. Activity guided fractionation of the decoction of the S. cumini was carried out by sequential extraction with organic solvents of different polarities. Thin Layer Chromatography (TLC) with authentic compounds and HPLC were performed for identification and confirmation of the compounds in the decoction and the RTS herbal drink. Presence of gallic and ellagic acids in the decoction and RTS herbal drink was proven and confirmed with HPLC. The LC UV-VIS spectra of the two compounds were identical with the corresponding spectra of the library. Further, gallic acid and umbelliferone were determined as the active compounds in the decoction by TLC and were confirmed by cochromatography with authentic compounds. The present investigation confirmed the presence of gallic acid, ellagic acid, and umbelliferone which are proven to have antidiabetic activities in the decoction and the RTS herbal drink prepared with the decoction.

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Syzygium cumini and the regeneration of insulin positive cells from the pancreatic duct

Cited by 28 publications

References 0 publications

Pharmacological potentials of Syzygium cumini: a review

Pharmacological potentials of Syzygium cumini: a review

Phytochemistry, traditional uses and pharmacology of Eugenia jambolana Lam. (black plum): A review

Antidiabetic Compounds in Syzygium cumini Decoction and Ready to Serve Herbal Drink

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