Changing trends of dengue disease: a brief report from a tertiary care hospital in New Delhi

Abstract

were relatively different from the earlier published one 1 and are being reported here. We wish to highlight the changing trends in the presentation of dengue from the same Dengue Serosurveillance Laboratory during this period.In contrast to 2002-2006 findings where Den-2 was the commonest serotype reported, ongoing study observed Den-1 to be the most prevalent serotype during 2007-2009. Den-1 was isolated in 50% of RT-PCR positive cases (20/40), whereas Den-2, Den-3 and Den-4 were identified in 22.5 %( 9/40), 15 % (6/40) and 12.5% (5/40) of cases respectively, indicating the replacement of earlier circulating Den-2 and Den-3 by Den-1. Maximum number of Den-1 cases were isolated in the year 2008 (findings published earlier).2 These findings provide an insight to the changing trend of dengue serotypes indicating that all four serotypes are continuously co-circulating, which makes this region prone to epidemic spreads.Although the abovementioned study 1 and few other studies 3 have reported Den-1 to be associated with a milder form of disease, our study demonstrates a rise in number of Den-1 affected severe cases during [2007][2008][2009]. Sixty percent of the Den-1 affected cases presented with severe DHF. Moreo-

A study of clinical and laboratory profile of dengue fever in a tertiary care centre of Uttarakhand, India

“…24 Rare but serious manifestations of dengue include encephalitis myocarditis, ARDS, shock, liver failure. 7,[25][26][27][28][29][30] In this study also mortality resulted because of these complications. Maximum number of cases is seen in rainy post rainy seasons because of water logging which acts as breeding ground for mosquitoes.…”

“…3,4 The resurgence of dengue has been observed in India and varied clinical presentations are being reported in the outbreaks reported from different geographical locations. [5][6][7][8][9][10][11] was of 1year from July 2012 to June 2013. The consenting patients of 12 years of age or above it who were antigen positive or antibody positive were included in the study.…”