“…States from the south region (Rio Grande do Sul, Santa Catarina and Paraná), which concentrate 20% of the Brazilian AIDS cases [1], display a distinct molecular epidemiology profile characterized by the high prevalence of subtypes C, B and BC recombinants. It has been estimated that subtype C represents around 20–30% of HIV-1 infections in Paraná [3], [7], [8], [9], [10], 30–45% of HIV-1 infections in Rio Grande do Sul [3], [11], [12], [13], [14], [15], and 50–80% of HIV-1 infections in Santa Catarina [14], [16], [17], [18].…”