What do we (not) know about the human bartonelloses?

Velho, Paulo Eduardo Neves Ferreira; Cintra, Maria Letícia; Uthida-Tanaka, Ana Maria; Moraes, Aparecida Machado de; Mariotto, Andréia

doi:10.1590/s1413-86702003000100001

Cited by 23 publications

(17 citation statements)

References 47 publications

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“…With electronic microscopy, individual trilaminar cell wall bacilli, consistent with Bartonella species, were observed in erythrocytes, skin, liver, and pleural and peritoneal tissues [1,4,5]. Bartonella sp.…”

Section: Discussionmentioning

confidence: 96%

Severe Anemia, Panserositis, and Cryptogenic Hepatitis in an HIV Patient Infected withBartonella henselae

Velho

Pimentel

Negro

et al. 2007

Ultrastructural Pathology

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Bartonella spp. constitute emerging pathogens of worldwide distribution. Bacillary angiomatosis is the most frequent skin manifestation of bartonelloses; nevertheless, B. henselae infection should always be considered systemic, especially in immunodeficient individuals. The authors report the case of an AIDS patient with bacillary angiomatosis, who had concurrent severe anemia, hepatitis, peritonitis, pleuritis, and pericarditis. Clinical manifestation, electronic microscopic examination of erythrocytes, and histopathology of a papule biopsy suggested a Bartonella sp. infection. Multiple genes were target by PCR and B. henselae DNA was amplified and sequenced (GenBank accession number EF196804) from the angiomatous papule. Treatment with clarithromycin resulted in resolution of the bacillary angiomatosis, fever, anemia, panserosites, and hepatitis.

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Section: Discussionmentioning

confidence: 96%

Severe Anemia, Panserositis, and Cryptogenic Hepatitis in an HIV Patient Infected withBartonella henselae

Velho

Pimentel

Negro

et al. 2007

Ultrastructural Pathology

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“…Bartonella quintana, the causative agent of trench fever, and the closely related B. bacilliformis, are also transmitted by arthropods [77]. Immunocompromised individuals, including AIDS patients and transplant recipients, are at risk for complications of infection with B. quintana, which has been associated with bacillary angiomatosis and peliosis hepatitis in these patients [17,19,28,111]. Humans are the only known non-arthropod reservoir for these two species of Bartonella, although monkeys have been infected experimentally with B. quintana [19].…”

Section: Vector-borne Diseasesmentioning

confidence: 99%

Important emerging bacterial zoonotic infections affecting the immunocompromised

2005

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-The immunocompromised are at particular risk for infection with zoonotic diseases. Persons can be temporarily immunocompromised due to pregnancy or developmental stage (i.e. infants); longer-term or permanent states of immunosuppression can occur as a result of immunosuppressive treatment following cancer or organ transplant, or from infectious diseases, such as AIDS. The focus of this review article is on emerging bacterial zoonotic diseases that are of particular concern among the immunocompromised. Factors that affect disease emergence can include factors such as human demographics and behavior; technology and industry; economic development and land use; international travel and commerce; microbial adaptation and change; and breakdown of public health measures. The immunocompromised need to take precautions when engaging in seemingly normal activities such as food preparation; caring for companion animals; and recreational or occupational activities. The immunocompromised are not only more susceptible to infection, but often suffer more serious sequelae as a result of infection. This review article provides an overview of the major foodborne, respiratory, and vector-borne bacterial pathogens that affect the immunocompromised. The major categories of immunodeficiency are described. In addition, measures that can be taken to prevent infection, including the role of health education, are discussed.

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“…BA and bacillary peliosis, both characterized by proliferative vascular lesions and first identified in patients with AIDS, were described by Stoler et al (2) Bartonella is the only bacterial genus known to cause cutaneous angioproliferation (5). Of the 14 species identified, five are known to cause disease in humans and only two -B quintana and B henselae -have been associated with BA (6).…”

Section: Discussionmentioning

confidence: 99%

Bacillary Angiomatosis in an HIV-positive Man with Multiple Risk Factors: A Clinical and Epidemiological Puzzle

Mateen

Newstead

McClean

2005

Canadian Journal of Infectious Diseases and Medical Microbiolog

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A 36-year-old man with advanced AIDS presented with skin lesions, fever and weight loss. Physical examination revealed skin lesions suggestive of bacillary angiomatosis. Diagnostic imaging identified bone lesions, soft tissue masses and a single hepatic lesion. His clinical presentation was most consistent with Bartonella quintana; however, his risk for infection with B quintana was limited to a remote, brief period of homelessness. In contrast, his frequent contact with cats presented substantial potential exposure to Bartonella henselae. Diagnosing a Bartonella infection presents challenges. The detection of bacteremia is hindered by slow growth in BACTEC media (BD Diagnostic Systems, Canada). In the present case, recovery of the organism required blind subcultures after at least eight days of incubation. Speciation by 16s ribosomal RNA analysis confirmed B quintana as the pathogen. Because the patient presented with skin lesions, the diagnosis was straightforward; however, skin lesions are nondiagnostic in some cases. Microbiological confirmation of the diagnosis rests on sufficient clinical suspicion to apply labour-intensive laboratory protocols.Key Words: Bacillary angiomatosis; Bartonella; HIV Angiomatose bacillaire chez un homme séropositif à l'égard du VIH et présentant plusieurs facteurs de risque : énigme clinique et épidémiologiqueUn homme de 36 ans, rendu à un stade avancé du sida, a consulté pour des lésions cutanées, de la fièvre et une perte de poids. L'examen physique a révélé la présence de lésions qui laissaient penser à une angiomatose bacillaire. L'imagerie de diagnostic a montré des lésions osseuses, des masses de tissus mous et une seule lésion hépatique. Le tableau clinique était surtout compatible avec Bartonella quintana; toutefois, son risque d'infection à ce micro-organisme se limitait à une courte période éloignée de sans-abrisme. Par contre, ses nombreux contacts avec les chats augmentaient sensiblement son exposition à Bartonella henselae. Diagnostiquer une infection à Bartonella n'est pas une mince affaire. La détection de la bactériémie est entravée par la croissance lente du bacille dans les milieux BACTEC (BD Diagnostic Systems, Canada). Dans le présent cas, la récupération du micro-organisme a nécessité des souscultures en aveugle après au moins huit jours d'incubation. La différenciation des espèces par l'analyse de l'ARN ribosomique 16S a permis d'identifier l'agent pathogène comme B. quintana. Comme le patient présentait des lésions cutanées, le diagnostic a été sans appel. Toutefois, les lésions cutanées n'ont pas toujours une valeur diagnostique. La confirmation microbiologique du diagnostic repose sur une présomption clinique suffisamment forte pour justifier l'application de protocoles de laboratoire, exigeants en main-d'oeuvre.A 36-year-old HIV-positive man presented to the emergency room with a two-day history of fever, chills, cough, diarrhea and weight loss (22.5 kg) over the preceding 12 months. He was noted to have widespread polymorphic skin lesions and focal ar...

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What do we (not) know about the human bartonelloses?

Cited by 23 publications

References 47 publications

Severe Anemia, Panserositis, and Cryptogenic Hepatitis in an HIV Patient Infected withBartonella henselae

Severe Anemia, Panserositis, and Cryptogenic Hepatitis in an HIV Patient Infected withBartonella henselae

Important emerging bacterial zoonotic infections affecting the immunocompromised

Bacillary Angiomatosis in an HIV-positive Man with Multiple Risk Factors: A Clinical and Epidemiological Puzzle

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