Classificação por ressonância magnética da degeneração do disco intervertebral

Puertas, Eduardo Barros; Yamashita, H; Oliveira, Valdeci Manoel de; Souza, Paulo Satiro de

doi:10.1590/s1413-78522009000100009

Cited by 7 publications

(3 citation statements)

References 17 publications

(17 reference statements)

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“…7 On the basis of these features, degenerative IVD tissues are classified into five grades (Grade I-V) by MRI T2 spin-echo weighted images. 8,9 In general, in the final stage of IVD degeneration (Grade V), MRI images show the extrusion of the NP passing through the fissured AF structure, resulting in the generation of LBP due to nerve root compression. However, even in the absence of nerve compression in MRI images, LBP occurs in patients with IVD degeneration.…”

Section: Introductionmentioning

confidence: 99%

Spine-on-a-chip: Human annulus fibrosus degeneration model for simulating the severity of intervertebral disc degeneration

et al. 2017

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The aetiology of intervertebral disc (IVD) degeneration accompanied by low back pain (LBP) is largely unknown, and there are no effective fundamental therapies. Symptomatic IVD is known to be associated with nerve root compression. However, even in the absence of nerve compression, LBP occurs in patients with IVD degeneration. We hypothesize that this phenomenon is associated with a concentration of pro-inflammatory cytokines such as interleukin (IL)-1β and tumour necrosis factor-alpha (TNF-α), which can lead to altered histologic features and cellular phenotypes observed during IVD degeneration. This study investigated the effects of the concentration of IL-1β and macrophage derived soluble factor including IL-1β and TNF-α on the painful response of human annulus fibrosus (AF) cells using a newly developed spine-on-a-chip. Human AF cells were treated with a range of concentrations of IL-1β and macrophage soluble factors. Our results show that increasing the concentration of inflammatory initiator caused modulated expression of pain-related factors, angiogenesis molecules, and catabolic enzymes. Furthermore, accumulated macrophage derived soluble factors resulted in morphological changes in human AF cells and kinetic alterations such as velocity, dendritic length, cell area, and growth rate, similar to that reported within degenerative IVD. Thus, a better understanding of the relationships between molecular and kinetic alterations can provide fundamental information regarding the pathology of IVD degenerative progression.

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Section: Introductionmentioning

confidence: 99%

Spine-on-a-chip: Human annulus fibrosus degeneration model for simulating the severity of intervertebral disc degeneration

et al. 2017

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“…This entire pathophysiologic process is also characteristic of normal human aging; there are reports of a gradual reduction of the formation of cartilage in the growth plate starting at 16 years of age (6) , characterizing the beginning of discopathy without, however, causing any clinical manifestations. With its natural evolution, the column presents progressive instability in the affected area due to degeneration of the intervertebral disc, leading to a series of other events in other elements of the functional unit (7) . Note also that the presence of symptoms related to degenerative disc disease (DDD) depends on the cumulative interaction of a large set of factors, linked to the environment and lifestyle habits, such as micro and macrotrauma, occupation, smoking and atherosclerosis that are capable of modifying, to some degree, the natural progression of degeneration-which is genetically determined 8 , 9 , 10 , 11 .…”

Section: Introductionmentioning

confidence: 99%

Radiological Analysis of Experimental Disc Degeneration in Rabbits

Vialle

Arruda

et al. 2009

Revista Brasileira de Ortopedia (English Edition)

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Objective: To validate radiographic evaluation of a rabbit model for disc degeneration. Methods: Lumbar intervertebral discs of New Zealand rabbits were stabbed three times with a 18G needle at a limited depth of 5mm, through lateral approach. Serial radiographic images were taken on the early pre-and postoperative periods, and after four, eight and 12 weeks of the procedure, with subsequent analysis of disc height, osteophyte formation, endplate sclerosis, and presence of disc degeneration. The statistical analysis of data was validated by the Kappa coefficient, with a confidence interval (CI) of 95%. Results: A significant reduction of disc space was found on AP X-ray images after 12 postoperative weeks, with Kappa = 0.489 for CI 95% (0.25-0.72) with p < 0.001. X-ray signs of disc degeneration also presented Kappa = 0.63 for CI 95% (0.39-0.86) with p < 0.001. The remaining assessed criteria showed positive results, but with a lower Kappa value. Conclusion: The disc degeneration model using rabbits as proposed in this study was shown to be feasible, with positive X-ray correlation between pre- and postoperative images, validating the potential to induce disc degeneration in this animal model for future studies.

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“…Todo esse processo fisiopatológico também é característico do envelhecimento humano normal, havendo relatos de redução gradual da formação de cartilagem na placa de crescimento já a partir dos 16 anos de idade (6) , caracterizando o início da discopatia, entretanto, sem gerar quaisquer manifestações clínicas. Com sua evolução natural, devido à degeneração do disco intervertebral, verifica-se que a coluna passa a apresentar instabilidade progressiva da região afetada, conduzindo a uma série de outros eventos nos demais elementos da unidade funcional segmentar (7) . Destaca-se ainda que a presença de sintomas relacionados com a DDD (Doença Degenerativa Discal) depende da interação acumulativa de grande grupo de fatores, ambientais e ligados aos hábitos de vida, tais como: micro ou macrotraumatismos, ocupação profissional, tabagismo e aterosclerose, capazes de modificar, em certo grau, a progressão natural da degeneração -geneticamente determinada (8)(9)(10)(11) .…”

Section: Introductionunclassified

Análise radiológica da degeneração discal experimental em coelhos

Vialle¹,

Vialle²,

Arruda³

et al. 2009

Rev. bras. ortop.

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RESUMOObjetivo: Validar a avaliação radiográfica da degeneração discal experimental em coelhos. Métodos: Os discos intervertebrais lombares de coelhos New Zealand foram puncionados três vezes com uma agulha 18G com profundidade limitada de 5mm, através de abordagem lateral. Foram realizadas radiografias seriadas pré e pós-operatórias imediatas, e depois de quatro, oito e 12 semanas do procedimento, com posterior análise da altura discal, formação de osteófito, esclerose da placa vertebral e presença de degeneração discal. A análise estatística dos dados foi validada pelo coeficiente de concordância Kappa, com intervalo de confiança (IC) de 95%. Resultados: Observou-se diminuição significativa do espaço discal nas radiografias em AP após 12 semanas de pós-operatório, com Kappa = 0,489 para IC 95% (0,25-0,72) com p < 0,001. Os sinais radiográficos de degeneração discal também apresentaram valor de Kappa = 0,63 para IC 95% (0,39-0,86) com p < 0,001. Os demais critérios avaliados tiveram resultados positivos, porém, com menor valor de Kappa. Conclusão: O modelo de degeneração discal em coelhos proposto neste estudo mostrou-se factível, com correlação radiológica positiva entre as imagens pré e pós-operatórias, validando a possibilidade de indução de degeneração discal nesse modelo animal para futuros estudos. ABSTRACTObjective: To validate radiographic evaluation of a rabbit model for disc degeneration. Methods: Lumbar intervertebral discs of New Zealand rabbits were stabbed three times with a 18G needle at a limited depth of 5mm, through lateral approach. Serial radiographic images were taken on the early pre-and postoperative periods, and after four, eight and 12 weeks of the procedure, with subsequent analysis of disc height, osteophyte formation, endplate sclerosis, and presence of disc degeneration. The statistical analysis of data was validated by the Kappa coefficient, with a confidence interval (CI) of 95%. Results: A significant reduction of disc space was found on AP X-ray images after 12 postoperative weeks, with Kappa = 0.489 for CI 95% (0.25-0.72) with p < 0.001. X-ray signs of disc degeneration also presented Kappa = 0.63 for CI 95% (0.39-0.86) with p < 0.001. The remaining assessed criteria showed positive results, but with a lower Kappa value. Conclusion: The disc degeneration model using rabbits as proposed in this study was shown to be feasible, with positive X-ray correlation between pre-and postoperative images, validating the potential to induce disc degeneration in this animal model for future studies. . Declaramos inexistência de conflito de interesses neste artigo ARTIGO ORIGINALRev Bras Ortop. 2009;44(4):313-9

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Classificação por ressonância magnética da degeneração do disco intervertebral

Cited by 7 publications

References 17 publications

Spine-on-a-chip: Human annulus fibrosus degeneration model for simulating the severity of intervertebral disc degeneration

Spine-on-a-chip: Human annulus fibrosus degeneration model for simulating the severity of intervertebral disc degeneration

Radiological Analysis of Experimental Disc Degeneration in Rabbits

Análise radiológica da degeneração discal experimental em coelhos

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