Síndrome antissintetase anti-Jo-1

Shinjo, Samuel Katsuyuki; Levy‐Neto, Maurício

doi:10.1590/s0482-50042010000500003

Cited by 23 publications

(5 citation statements)

References 38 publications

(32 reference statements)

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“…4 Therefore, in some cases, the interstitial lung disease is predominant in the Antisynthetase Syndrome. The interstitial disease can have a slow onset and lead to acute respiratory failure, sometimes highly refractory to treatment.…”

Section: Discussionmentioning

confidence: 99%

Antisynthetase Syndrome: two case reports and literature review

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Brandão

Goulart

et al. 2015

Revista Brasileira de Reumatologia (English Edition)

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r e v b r a s r e u m a t o l . 2 0 1 5;5 5(2):177-180 w w w . r e u m a t o l o g i a . c o m . b r Interstitial lung disease a b s t r a c t Antisynthetase Syndrome (ASS) is characterized by myositis, Raynaud's phenomenon, fever, interstitial lung disease, mechanic's hands and arthropathy associated with the presence of antibodies against tRNA synthetase, especially anti-Jo-1. This article aims to review the literature on ASS and report two cases where the first is a patient with polymyositis who developed subluxation on the proximal interphalangeal joint of bilateral first right finger after a few years of the disease, associated with pulmonary manifestations and positive anti-JO-1. In the second case, we present a patient with dermatomyositis, who developed a subluxation of the two first fingers, anti-Jo1 positive and chest CT changes, but without clinical evidence of pulmonary involvement. These cases reveal the importance of performing early diagnosis. The authors describe two cases of this rare syndrome, emphasizing the severity of interstitial lung disease and arthritis. Síndrome Antissintetase: relato de dois casos e revisão da literatura Palavras-chave: Síndrome antissintetase Polidermatomiosite Anti-Jo 1 Doença intersticial pulmonar r e s u m o A Síndrome Antissintetase (SAS) é caracterizada por miosite, fenômeno de Raynaud, febre, doença pulmonar intersticial, artropatia e mãos de mecânico associados à presença de anticorpos contra a sintetase do RNAt especialmente anti-Jo-1. Este artigo tem como objetivo revisar a literatura sobre SAS e relatar dois casos, sendo o caso 1 de uma paciente com Polimiosite que desenvolveu, após alguns anos de doença, subluxação da articulação interfalangeana proximal do primeiro quirododáctilo direito, associada a manifestaç ões pulmonares e antiJo-1 positivo. O caso 2 é de uma paciente com Dermatomiosite que evoluiu com subluxação dos dois primeiros quirodáctilos, anti-Jo-1 positivo e alteraç ões pulmonares intersticiais na

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Section: Discussionmentioning

confidence: 99%

Antisynthetase Syndrome: two case reports and literature review

Theilacker

Brandão

Goulart

et al. 2015

Revista Brasileira de Reumatologia (English Edition)

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“…In the absence of pulmonary involvement, the diagnosis is referred to as anti-GBM disease. [2][3][4] ANCA is found in 30 to 47% of patients with anti-GBM disease and thus, histological evidence is of paramount importance for correct diagnosis of anti-GBM disease, because patients might be erroneously treated for ANCA-associated vasculitis. 3 The pathogenic effects of anti-GBM was demonstrated by Lerner et al through the induction of glomerulonephritis in monkeys.…”

Section: Discussionmentioning

confidence: 99%

“…High-dose corticosteroids and cyclophosphamide are mostly used, and the duration of therapy with the latter is approximately six months. [2][3][4] Notwithstanding these recommendations, our patient was managed successfully with immunosuppressive drugs alone, because of the unavailability of plasmapheresis at the time when he was acutely ill.…”

Section: Discussionmentioning

confidence: 99%

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Association of anti-glomerular basement membrane antibody disease with dermatomyositis and psoriasis: case report

et al. 2010

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CONTEXT: Anti-glomerular basement membrane (anti-GBM) antibody syndrome is characterized by deposition of anti-GBM antibodies on affected tissues, associated with glomerulonephritis and/or pulmonary involvement. This syndrome has been described in association with other autoimmune disorders, but as far as we know, it has not been described in association with dermatomyositis and psoriasis.CASE REPORT: A 51-year-old man with a history of dermatomyositis and vulgar psoriasis presented with a condition of sensitive-motor polyneuropathy of the hands and feet, weight loss of 4 kg, malaise and fever. On admission, he had been making chronic use of cyclosporin and antihypertensive drugs for three months because of mild arterial hypertension. Laboratory tests showed anemia and leukocytosis, elevated serum urea and creatinine and urine presenting proteinuria, hematuria, leukocyturia and granular casts. The 24-hour proteinuria was 2.3 g. Renal biopsy showed crescentic necrotizing glomerulonephritis with linear immunoglobulin G (IgG) deposits on the glomerular basement membrane by means of direct immunofluorescence, which were suggestive of anti-GBM antibodies. The patient was then treated initially with methylprednisolone and with monthly cyclophosphamide in the form of pulse therapy. RESUMOCONTEXTO: A síndrome do anticorpo anti-membrana basal glomerular (anti-MBG) é caracterizada pela deposição de anticorpos anti-MBG em tecidos afetados, associada à glomerulonefrite e/ou ao envolvimento pulmonar. Essa síndrome já foi descrita em associação a outras doenças autoimunes, mas até onde conhecemos, não há relatos de sua associação com dermatomiosite e psoríase. RELATO DE CASO:Um homem de 51 anos com antecedentes de dermatomiosite e psoríase vulgar apresentou quadro de polineuropatia sensitivomotora de mãos e pés, perda de 4 kg, adinamia e febre. À admissão estava em uso crônico de ciclosporina e de anti-hipertensivos há três meses devido a hipertensão arterial leve. Exames laboratoriais mostraram anemia e leucocitose, creatinina e ureia séricas elevadas e urina com proteinúria, hematúria, leucocitúria e cilindros granulosos. A proteinúria de 24 horas foi de 2,3 g. A biópsia renal revelou uma glomerulonefrite crescêntica necrotizante com depósitos lineares de imunoglobulina G (IgG) na MBG à imunofluorescência, sugestivos de anticorpos anti-MBG. O paciente foi então tratado inicialmente com metilprednisolona e com ciclofosfamida mensalmente na forma de pulsoterapia.

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“…Antisynthetase syndrome (ASSD) is a rare systemic autoimmune myopathy characterized by muscle, joint, and pulmonary involvement, as well as by the presence of fever, "mechanic's hands," and Raynaud's phenomenon [1][2][3][4]. In the laboratory, the ASSD is characterized by the presence of anti-aminoacyl-tRNA synthetase autoantibodies, such as anti-Jo-1 [1,2].…”

Section: Introductionmentioning

confidence: 99%

High YKL-40 serum levels and its expression in the muscle tissues of patients with antisynthetase syndrome

2021

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Background The protein chitinase-3-like-1 (YKL-40) is rarely analyzed in patients with myositis. Therefore, we aimed to evaluate YKL-40 serum levels; correlate them with laboratory and clinical parameters, disease status, and treatment schemes; and analyze the YKL-40 expression in the muscle tissues of patients with antisynthetase syndrome (ASSD). Methods This cross-sectional single-center study included 64 adult patients with ASSD who were age-, gender-, and ethnicity-matched to 64 healthy control individuals. Their YKL-40 serum levels were analyzed using the Enzyme-Linked Immunosorbent Assay (ELISA) kit method, while YKL-40 expression in muscle tissues was analyzed using an immunohistochemical technique. Disease status was assessed using the International Myositis Assessment and Clinical Studies Group (IMACS) set scores. Results The patients’ mean age was 44.8 ± 11.8 years, and median disease duration was 1.5 (0.0–4.0) years. These patients were predominantly female (82.8%) and Caucasian (73.4%). Most patients had stable disease. The median YKL-40 serum level was significantly higher in patients with ASSD when compared to the healthy individuals: 538.4 (363.4–853.1) pg/mL versus 270.0 (201.8–451.9) pg/mL, respectively; P < 0.001. However, YKL-40 serum levels did not correlate with any clinical, laboratory, disease status, or therapeutic parameters (P > 0.050), except tumor necrosis factor alpha (TNF-α) serum levels (Spearman’s correlation, rho = 0.382; P = 0.007). YKL-40 was highly expressed by inflammatory cells found in muscle biopsy specimens. Conclusions High YKL-40 serum levels were observed in patients with ASSD and correlated positively with TNF-α serum levels. Moreover, YKL-40 was expressed by the inflammatory cells of the muscle tissue.

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Síndrome antissintetase anti-Jo-1

Cited by 23 publications

References 38 publications

Antisynthetase Syndrome: two case reports and literature review

Antisynthetase Syndrome: two case reports and literature review

Association of anti-glomerular basement membrane antibody disease with dermatomyositis and psoriasis: case report

High YKL-40 serum levels and its expression in the muscle tissues of patients with antisynthetase syndrome

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