2010
DOI: 10.1590/s0482-50042010000300013
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Abstract: TNF blockers have been used in the treatment of several types of chronic inflammatory arthritis, especially rheumatoid arthritis. However, many doubts regarding the safety and high risk of infectious diseases in these patients remain. The main objective of this report was to present a case of lepromatous leprosy in a rheumatoid arthritis patient using TNF blockers. The development of adverse events should be rigorously observed, especially those related to infectious agents. Thus, appropriate investigation of … Show more

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Cited by 18 publications
(9 citation statements)
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“…In South America, tuberculosis remains an endemic disease with an incidence of 41 (35-47)/100,000 in Brazil and 25 (22)(23)(24)(25)(26)(27)(28)(29)/100,000 in Argentina [20]. It was therefore expected a tuberculosis IR for all bDMARDs higher in Brazil (1.46/1000) than in Argentina (0.63), and the overall IR of 1.4/1000 found in this study reflects the background risk in our countries [21].…”
Section: Discussionmentioning
confidence: 99%
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“…In South America, tuberculosis remains an endemic disease with an incidence of 41 (35-47)/100,000 in Brazil and 25 (22)(23)(24)(25)(26)(27)(28)(29)/100,000 in Argentina [20]. It was therefore expected a tuberculosis IR for all bDMARDs higher in Brazil (1.46/1000) than in Argentina (0.63), and the overall IR of 1.4/1000 found in this study reflects the background risk in our countries [21].…”
Section: Discussionmentioning
confidence: 99%
“…Another mycobacterial disease that is still endemic in various South America areas is Hansen disease [24]. Single case reports have suggested a possible association between hanseniasis and exposure to TNFi [4,25]. Interestingly, no cases of Hansen disease classified as a SI have been reported in either registry.…”
Section: Discussionmentioning
confidence: 99%
“…In the literature, two cases have been described of patients who developed leprosy after taking anti-TNF-a drugs; two with infliximab and two with adalimumab. 4 , 6 , 8 …”
Section: Discussionmentioning
confidence: 99%
“…1 , 2 As regards infectious diseases, it encourages the release of other inflammatory cytokines, particularly interleukins IL-1, IL-6 and IL-8, and stimulates the output of protease, thus participating in the formation and maintenance of granulomas, a component of intracellular pathogen-defence. 2 - 4 …”
Section: Introductionmentioning
confidence: 99%
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