A importância dos níveis de vitamina D nas doenças autoimunes

Marques, Cláudia Diniz Lopes; Dantas, Andréa Tavares; Fragoso, Thiago Sotero; Duarte, Ângela Luzia Branco Pinto

doi:10.1590/s0482-50042010000100007

Cited by 85 publications

(69 citation statements)

References 50 publications

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“…The final stage of vitamin D production is the additional hydroxylation that occurs in the cells of the proximal convoluted tubule in the kidney, giving rise to 1,25-dihydroxyvitamin D or calcitriol, the biologically active form that exerts action through binding with the VDR [12,22].…”

Section: Metabolic and Physiological Aspects Of Vitamin Dmentioning

confidence: 99%

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Role of vitamin D in insulin resistance in obese individuals

Santos

Lima

Braz

et al. 2017

Nutrire

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Background: Vitamin D is a fat-soluble compound responsible for promoting intestinal absorption of calcium, and this, in turn, acts as a signal transmitter or activator as protein in secretory processes and release of hormones. Vitamin D receptors are distributed in various tissues of the body and involved in biochemical reactions in the pathogenesis of several diseases, such as obesity. Objective: The aim of this article is to provide updated information on the role of vitamin D in insulin resistance in obese individuals. Methods: It was conducted a search of articles published in PubMED, SciELO, and LILACS database, without limit for the year of publication, using the keywords "vitamin D", "insulin resistance", and "obesity". Results: Excess adipose tissue seems to impair insulin signaling by inhibiting the phosphorylation of its receptor, resulting in insulin resistance. Studies have evidenced role of vitamin D in mechanisms involved in the pathogenesis of insulin resistance in obesity by acting in improving glycemic control both by increasing hepatic and peripheral glucose uptake and by promoting the secretion of this hormone. Conclusions: Vitamin D exerts a protective effect in the treatment and prevention of insulin resistance in patients with obesity and protects the body against oxidative stress and chronic inflammation, contributing to glycemic control. Unfortunately, current data related to the effects of vitamin D supplementation on insulin resistance are still inconclusive.

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Section: Metabolic and Physiological Aspects Of Vitamin Dmentioning

confidence: 99%

“…Studies have shown that prolonged sun exposure isomerizes pre-vitamin D3 into two inert molecules, lumisterol and tachisterol, which impair vitamin D synthesis [20,22].…”

Section: Metabolic and Physiological Aspects Of Vitamin Dmentioning

confidence: 99%

Role of vitamin D in insulin resistance in obese individuals

Santos

Lima

Braz

et al. 2017

Nutrire

View full text Add to dashboard Cite

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“…In general, the effects of vitamin D in the immunologic system are the increase of innate immunity, associated with a multifaceted regulation of acquired immunity [13].…”

Section: Pathophysiologymentioning

confidence: 99%

Vitamin D and Diabetes Mellitus: A Review

Souza¹,

Sá²,

Rocha³

et al. 2016

OJEMD

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“…efits of sun exposure, and the effects of vitamin D on bone formation, but not on the prevention of autoimmune diseases 22 . Sunlight was also associated with an individual's state of welfare and happiness.…”

mentioning

confidence: 99%

“…Além do bronzeamento, os sujeitos reconhecem os reais benefícios do sol, como os efeitos da vitamina D sobre a formação óssea, mas não sobre a prevenção de doenças auto-imunes 22 . Associam, também, a luz solar ao estado de bem-estar e alegria dos indivíduos.…”

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Education about protection against solar radiation for teachers teaching young children: a contribution to promote school health

Leonardi

Banin

Corazza

et al. 2014

BBR

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Biomedical and Biopharmaceutical Research J o r n a l d e I n v e s t i g a ç ã o B i o m é d i c a e B i o f a r m a c ê u t i c aEducation about protection against solar radiation for teachers teaching young children: a contribution to promote school health AbstractSkin cancer Primary prevention should focus young populations, using the school and teachers as strategic players. This paper describes results from a project aimed to educate kindergarten teachers in the Diadema municipality (metropolitan S Paulo) about photoeducation and sun exposure risks. The intervention was based on an investigation about teachers level of knowledge. Analysis revealed several gaps in knowledge topics -effects of skin tanning; sun exposure damage different than skin cancer; forms of sun protection, other than sunscreens; importance of sunscreen in childhood; types of solar radiation and their effects on human health; facts to be observed in the use of sunscreens. Based on the results of the first step, educational intervention was performed. The last step involved the evaluation of acquired knowledge. The collecting data technique was the Focal Group. Through content analysis, advances in knowledge and the acquisition of concepts were identified. The educational intervention was determinant for teachers knowledge especially regarding UVt radiation types and sun protection factors, but also revealed some pitfalls. In conclusion, short-term actions may be sufficient to transform some concepts but not enough to achieve all goals, especially the transformation of concepts related to cultural aspects, demanding greater daily educational investments.Keywords: photoeducation, health, skin, school health, children ResumoA prevenção primária do câncer da pele deve focar-se nas crianças , em especial, na escola e nos professores como elementos estratégicos. Este artigo descreve os resultados de um projeto de extensão de capacitação de professores de uma escola do município de Diadema (região metropolitana de São Paulo) para a educação sobre riscos da exposição solar e fotoproteção. A intervenção ocorreu a partir da investigação do conhecimento dos professores. Os resultados revelaram diversas lacunas em tópicos importantes -consequências do bronzeamento da pele; danos da exposição solar, além do câncer; proteção solar, além dos filtros solares; importância da proteção solar na infância; tipos de radiação e seus efeitos à saúde humana; critérios do uso de filtros solares. Com base nos resultados foi realizada intervenção educativa. Na última etapa realizou-se avaliação do conhecimento adquirido. O Grupo Focal e a análise de conteúdo, revelaram o impacto da intervenção educativa no conhecimento de professores, especialmente quanto aos tipos de radiação UV e fator de proteção solar, mas também alguns problemas. Em conclusão, a intervenção educativa de curta duração foi eficaz para transformar conceitos, mas não suficiente para atingir todos os objetivos, especialmente a transformação de conceitos ligados a aspectos culturais, os quais prec...

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A importância dos níveis de vitamina D nas doenças autoimunes

Cited by 85 publications

References 50 publications

Role of vitamin D in insulin resistance in obese individuals

Role of vitamin D in insulin resistance in obese individuals

Vitamin D and Diabetes Mellitus: A Review

Education about protection against solar radiation for teachers teaching young children: a contribution to promote school health

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