2009
DOI: 10.1590/s0482-50042009000300010
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Abstract: Rheumatoid cachexia can be defined as an involuntary loss of body cell mass, which predominates in skeletal muscle, but is also observed in the viscera and immune system. It occurs with little or no weight loss in the presence of stable or increased fat mass. The etiology is likely multifactorial, and involves excessive inflammatory cytokine production, namely excess tumor necrosis factor-α and interleukin-1β production, reduced peripheral insulin action, and low habitual physical activity. Cachexia occurs in … Show more

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Cited by 7 publications
(1 citation statement)
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“…In addition to articular manifestations, RA has several systemic manifestations that significantly influence its morbidity and mortality. Rheumatoid cachexia is one of these systemic manifestations that has been receiving more attention due to its impact in function and quality of life, occurring in approximately 10 to 66 % of RA patients. It is characterized by disruption of muscle protein synthesis and degradation of balance, increased basal metabolic rate, total energy expenditure, insulin resistance, and inflammation, as well as decreased muscle mass, strength, and function .…”
Section: Introductionmentioning
confidence: 99%
“…In addition to articular manifestations, RA has several systemic manifestations that significantly influence its morbidity and mortality. Rheumatoid cachexia is one of these systemic manifestations that has been receiving more attention due to its impact in function and quality of life, occurring in approximately 10 to 66 % of RA patients. It is characterized by disruption of muscle protein synthesis and degradation of balance, increased basal metabolic rate, total energy expenditure, insulin resistance, and inflammation, as well as decreased muscle mass, strength, and function .…”
Section: Introductionmentioning
confidence: 99%