2009
DOI: 10.1590/s0482-50042009000300009
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: CD55 and CD59 are glycosylphosphatidylinositol-anchored proteins with regulatory properties on the activating cascades of the complement system. This regulation occurs through inhibition of the C3-convertase formation by CD55, and prevention of the terminal polymerization of the membrane attack complex by CD59. Deficiency in the expression of these proteins can be associated with increased susceptibility to complement-mediated cell death. Systemic lupus erythematosus patients with hemolytic anemia and lymphope… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

0
8
0

Year Published

2010
2010
2020
2020

Publication Types

Select...
6
1

Relationship

0
7

Authors

Journals

citations
Cited by 9 publications
(8 citation statements)
references
References 65 publications
0
8
0
Order By: Relevance
“…Despite of not having been one of the objectives of this work, it is important to comment that some hypotheses could explain the occurrence of the three inconclusive cases: the presence of small clonal populations of PNH cells masked by normal cells from transfusions within the three months prior to the tests; (5,7,11-13,16,17) small populations of granulocytes without glycosylphosphatidylinositol-anchored proteins in patients with aplastic anemia or myelodysplastic syndrome but without evidence of hemolysis or other presentations of PNH, with the exception of altered hematopoietic production, and cross reactions with auto-antibodies for other autoimmune diseases such as systemic lupus erythematosus, (3,9,10,12) as was observed in one of the inconclusive cases presented in this study and only diagnosed correctly as negative for PNH after the suspension of treatment with prednisone.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Despite of not having been one of the objectives of this work, it is important to comment that some hypotheses could explain the occurrence of the three inconclusive cases: the presence of small clonal populations of PNH cells masked by normal cells from transfusions within the three months prior to the tests; (5,7,11-13,16,17) small populations of granulocytes without glycosylphosphatidylinositol-anchored proteins in patients with aplastic anemia or myelodysplastic syndrome but without evidence of hemolysis or other presentations of PNH, with the exception of altered hematopoietic production, and cross reactions with auto-antibodies for other autoimmune diseases such as systemic lupus erythematosus, (3,9,10,12) as was observed in one of the inconclusive cases presented in this study and only diagnosed correctly as negative for PNH after the suspension of treatment with prednisone.…”
Section: Discussionmentioning
confidence: 99%
“…Rarely, spontaneous remission occurs (10% to 15% of cases) or transformation to acute myeloid leukemia. (3,9,13,14) …”
Section: Introductionmentioning
confidence: 99%
“…Despite of not having been one of the objectives of this work, it is important to comment that some hypotheses could explain the occurrence of the three inconclusive cases: the presence of small clonal populations of PNH cells masked by normal cells from transfusions within the three months prior to the tests; (5,7,(11)(12)(13)16,17) small populations of granulocytes without glycosylphosphatidylinositolanchored proteins in patients with aplastic anemia or myelodysplastic syndrome but without evidence of hemolysis or other presentations of PNH, with the exception of altered hematopoietic production, and cross reactions with autoantibodies for other autoimmune diseases such as systemic lupus erythematosus, (3,9,10,12) as was observed in one of the inconclusive cases presented in this study and only diagnosed correctly as negative for PNH after the suspension of treatment with prednisone.…”
Section: Discussionmentioning
confidence: 99%
“…Point mutations can also occur producing a partially functional molecule. (3)(4)(5)(6) This defect results in a deficiency in the biosynthesis of glycosylphosphatidylinositol (GPI) which is responsible for the anchorage and fixation of the regulatory antigens of the complement system (CS), CD55 antigen or decay accelerating factor (DAF) and CD59 antigen or membrane inhibitor of reactive lysis (MIRL), on the outer surface of erythrocyte, leukocyte and platelet membranes. This makes these cells vulnerable to lysis mediated by complement which results in hemolytic anemia, a certain degree of bone marrow insufficiency and the release of large amounts of free hemoglobin into the plasma, which can lead to an increase in the consumption of nitric oxide and clinical manifestations that include fatigue, abdominal pain, esophageal spasms, erectile dysfunction and various degrees of thrombosis (classic or subclinical PNH).…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation