Sarcopenia associada ao envelhecimento: aspectos etiológicos e opções terapêuticas

Abstract

artigo dE rEvisão rEviEw articlE RESUMO A prevalência de incapacidade e dependência funcional é maior em idosos e está intimamente associada à redução da massa muscular, que ocorre, até mesmo, em indivíduos saudáveis. A sarcopenia parece decorrer da interação complexa de distúrbios da inervação, diminuição de hormônios, aumento de mediadores inflamatórios e alterações da ingestão protéico-calórica que ocorrem durante o envelhecimento. A perda de massa e força muscular é responsável pela redução de mobilidade e aumento da incapacidade funcional e dependência. Quando associada à fragilidade, esta perda gera custos econômicos e sociais. Neste artigo, pretende-se avaliar aspectos relacionados à gênese da sarcopenia, bem como analisar possíveis opções terapêuticas e de prevenção.

A study on the relationship between muscle function, functional mobility and level of physical activity in community-dwelling elderly

“…Sarcopenia, defined as the slow, progressive and apparently inevitable loss of muscle mass and strength, is one of the most important physiological changes that occur with advancing age 1 . The reduction of muscle mass associated with aging seems to be the primary factor responsible for reduction in muscle strength and power and the consequent loss of functional mobility in elderly people [2][3][4] .…”

Elaboration of biscuits with oatmeal and fat palm with added L-leucine and calcium for sarcopenia

“…According to Silva et al (2006) and Roberts (1995) malnutrition is a serious factor for sarcopenia since the majority of the elderly do not consume enough protein according to the recommended daily intake of protein. Houston et al (2008) evaluated a group of elderly in order to associate protein diet and muscle mass loss and concluded that a diet with proteins can be a modifiable risk factor to reduce the risk of sarcopenia.…”

“…Matz (1968 apud SILVA;SILVA;CHANG, 1998), argues that the biscuits with very high or very low expansion index cause problems to the industry resulting in very high weight or small-sized products.…”

Quality of life evaluation of frail elderly in Campinas, São Paulo

“…Consequences include falls, dependency, disability, decreased QoL, institutionalization and death. 8,9 It is a process with a singular and complex biological basis, which cannot be explained only by senescence.…”