Treatment of common warts with the immune stimulant Propionium bacterium parvum

Abstract

BACKGROUND: Warts are epithelial proliferations in the skin and mucous membrane caused by various types of HPV. They can decrease spontaneously or increase in size and number according to the patient's immune status. The Propionium bacterium parvum is a strong immune stimulant and immune modulator and has important effects in the immune system and it is able to produce antibodies in the skin. OBJECTIVE: To show the efficacy of the Propionium bacterium parvum in saline solution in the treatment of skin warts. METHODS: A randomized double-blind study. Twenty patients with multiple warts were divided into two groups: one received 0,1ml intradermal injection of placebo solution in just one of the warts and the other received 0,1 ml of saline solution of Propionium bacterium parvum, one dose a month, for 3 to 5 months. RESULTS: Among the 20 patients who participated in the study, ten received the placebo and ten received the saline solution with Propionium bacterium parvum. In 9 patients treated with the Propionium bacterium parvum solution the warts disappeared without scars and in 1 patient it decreased in size. In 9 patients who received the placebo no change to the warts was observed and in 1 it decreased in size. CONCLUSIONS: The immune modulator and immune stimulant Propionium bacterium parvum produced antibodies in the skin which destroyed the warts without scars, with statistically significant results (P<0,001), and cured 90 % of the patients. We suggest the use of the immune stimulant in the treatment of warts.

Evolving role of immunotherapy in the treatment of refractory warts

“…[ 72 ] In a study involving 10 patients with cutaneous warts (common warts) that compared 0.1 ml immune stimulant Corynebacterium parvum vs saline administered intradermally every month for 3–5 months, 9 patients showed complete resolution. [ 73 ] Herbal preparations such as Echinacea and propolis are reported to boost the immunity when administered orally. [ 74 ] Sinecatechins are derived from green tea extract ( Camellia sinensis ) and is marketed as a 10% ointment.…”

Immunomodulators in warts: Unexplored or ineffective?

“…Nasser conducted a randomized DB PC trial in 28 volunteers with common warts, out of which 20 completed the study. [ 86 ] Intradermal application of 0.1 ml of the drug or placebo was done in one wart each time at intervals of 30-40 days for a total of up to five times. A mild local reaction developed in some warts, indicating the antigen-antibody complex formation.…”

The long‐standing history of Corynebacterium parvum, immunity, and viruses

“…Our literature search was not able to find in the past any human trial or anecdotal report on C. parvum treatment of viral infections except the contribution of Papaevangelou et al 27 and Nasser 54 (see above).…”

“…Coming to clinical trials, Nasser 54 treated 20 patients severely affected by multiple common warts infections (caused by different strains of papilloma virus) with repeated local injections of C. parvum , 0.2 mL subcutis (10 patients) compared with placebo (saline solution) 44 . The procedure was repeated from 1 to 5 months dependently by the regression rate and it was definitely effective in 9 cases out of 10, with partial regression in the last one but none of the placebo group had any benefit except one partial regression.…”