2011
DOI: 10.1590/s0365-05962011000700031
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Abstract: Abstract:The umbilicus can be affected by various skin diseases including metastasis of internal malignancies, at which point it is known as Sister Mary Joseph's Nodule. The authors report a case of Sister Mary Joseph's Nodule as the first sign of internal malignancy and highlight the importance for the dermatologist to recognize the condition. Keywords: Neoplasm metastasis; Ovarian neoplasms; Umbilicus Resumo: A cicatriz umbilical pode ser acometida por diversas dermatoses inclusive metástase de neoplasias in… Show more

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Cited by 27 publications
(48 citation statements)
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References 7 publications
(6 reference statements)
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“…To explore the possible pathomechanism leading to skin metastatization, we have tested lymphovascular invasion rate in available metastatic samples [9] using immunohistochemistry to differentiate between blood (CD31+/CD34+) and lymphatic (D-240+) vessels. Definitive vascular invasion was proved only in 4 cases (28.6 %).…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…To explore the possible pathomechanism leading to skin metastatization, we have tested lymphovascular invasion rate in available metastatic samples [9] using immunohistochemistry to differentiate between blood (CD31+/CD34+) and lymphatic (D-240+) vessels. Definitive vascular invasion was proved only in 4 cases (28.6 %).…”
Section: Resultsmentioning
confidence: 99%
“…One well known exception exists, namely the periumbilical region which remains to be linked with the abdominal viscera via the umbilical artery. This phenomenon could explain the development of the so called Sister Mary Joseph's nodule, which is the metastatic tumor of the umbilicus deriving commonly from the abdominal organs, frequently associated with peritoneal carcinosis [7,9].…”
Section: Discussionmentioning
confidence: 99%
“…The primary tumor most frequently is ovarian carcinoma in women and gastric cancer in men [28]. Despite the direct blood vessel connection, such type of metastasis is rare among skin metastases [27,28]. Furthermore, in our recent report on abdominal skin metastases of gastrointestinal cancers, we found no association with peritoneal involvement [18].…”
Section: Vascular Anatomy and Lymphovascular Disseminationmentioning
confidence: 53%
“…The one exception is the periumbilical skin region which is directly connected to abdominal organs through the umbilical artery. Accordingly, abdominal cancers at the stage of peritoneal dissemination may metastasize into the umbilicus also called Sister Mary Joseph's nodule [27]. The primary tumor most frequently is ovarian carcinoma in women and gastric cancer in men [28].…”
Section: Vascular Anatomy and Lymphovascular Disseminationmentioning
confidence: 99%
“…1 , and frequency of skin metastasis of colorectal carcinoma has been reported to be 2.3-6% 2 , most of them appearing near the site of the primary tumor. Therefore, the CM of colonic tumors is usually in the pelvis and abdomen 3 .…”
Section: Introductionmentioning
confidence: 99%