Lipomatose simétrica benigna e pelagra, associadas ao alcoolismo

Filgueiras, Fernanda de Marca; Stolarczuk, Dionne de Almeida; Gripp, Alexandre Carlos; Succi, Isabel Cristina Brasil

doi:10.1590/s0365-05962011000600021

Cited by 8 publications

(4 citation statements)

References 4 publications

(24 reference statements)

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“…The distinctive pathological characteristic of MSL is the substantial adipocyte accumulation in the subcutaneous adipose tissue (SAT), but most patients do not demonstrate dysfunction of glucose or lipid metabolism, as reported previously in one case by us 3 4 . Chronic alcohol ingestion or A8344G mutation of mitochondrial DNA has been considered as an important risk factor for MSL 5 6 7 . However, the molecular mechanism of the enhanced differentiation of adipocytes in MSL remains to be determined.…”

mentioning

confidence: 99%

miR-125a-3p and miR-483-5p promote adipogenesis via suppressing the RhoA/ROCK1/ERK1/2 pathway in multiple symmetric lipomatosis

Chen

Xie

et al. 2015

Sci Rep

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Multiple symmetric lipomatosis (MSL) is a rare disease characterized by symmetric and abnormal distribution of subcutaneous adipose tissue (SAT); however, the etiology is largely unknown. We report here that miR-125a-3p and miR-483-5p are upregulated in the SAT of MSL patients, promoting adipogenesis through suppressing the RhoA/ROCK1/ERK1/2 pathway. TaqMan microRNA (miR) array analysis revealed that 18 miRs were upregulated in the SAT of MSL patients. Transfection of human adipose-derived mesenchymal stem cells (hADSCs) with the individual agomirs of these 18 miRs showed that miR-125a-3p and miR-483-5p significantly promoted adipogenesis. A dual-luciferase assay showed that RhoA and ERK1 were the targets of miR-125a-3p and miR-483-5p, respectively. Moreover, transfection of hADSCs with mimics of miR-125a-3p and miR-483-5p resulted in a pronounced decrease of ERK1/2 phosphorylation in the nucleus; conversely, transfection of hADSCs with inhibitors of miR-125a-3p and miR-483-5p led to a significant increase of ERK1/2 phosphorylation in the nucleus. Most importantly, we found that miR-125a-3p and miR-483-5p promoted de novo adipose tissue formation in nude mice. These results demonstrated that miR-125a-3p and miR-483-5p coordinately promoted adipogenesis through suppressing the RhoA/ROCK1/ERK1/2 pathway. Our findings may provide novel strategies for the management and treatment of MSL or obesity.

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mentioning

confidence: 99%

miR-125a-3p and miR-483-5p promote adipogenesis via suppressing the RhoA/ROCK1/ERK1/2 pathway in multiple symmetric lipomatosis

Chen

Xie

et al. 2015

Sci Rep

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“…It is most frequent in adult (age 30-60 years) males (with a 20:1 predominance), and is comorbid with alcoholism in 60-90% of cases. 4,5 …”

Section: Discussionmentioning

confidence: 99%

“…Ethanol consumption appears to potentiate the development of lesions in genetically predisposed patients, by downregulation of adrenergic receptors and inhibition of alpha oxidation of adipose tissue, leading to a decline in lipolysis and increase in lipogenesis. 4,6,7 …”

Section: Discussionmentioning

confidence: 99%

Syndrome in Question

Orasmo

Ocanha

Barraviera

et al. 2014

An. Bras. Dermatol.

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A 48-year-old male patient with chronic alcoholism presented with a soft, bulky, asymptomatic, and slow-growing mass in the posterior region of the neck, as well as nodules in the deltoid region and posterior triangle of the sternocleidomastoid muscle. Needle aspiration confirmed the diagnosis of lipoma. Multiple symmetric lipomatosis (Madelung's disease) is a rare proliferation of adipocytes, of unknown etiology, most common in middle-aged men and mainly associated with alcoholism. It predominantly affects the neck and upper trunk, causing compressive symptoms or a imparting a pseudoathletic appearance. Surgical resection or liposuction is the most effective treatment, despite frequent recurrence.

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“…A absorção da nicotinamida ocorre por difusão no estômago e intestino delgado, convertendo-se em suas formas ativas na circulação sanguínea, rins, fígado e cérebro sendo excretada pela urina (Sígolo; Magnoni; Cukier, 2014). Research, Society and Development, v. 9, n.1, e190911910, 2020 (CC BY 4.0) | ISSN 2525-3409 | DOI: http://dx.doi.org/10.33448/rsd-v9i1.1910 6 Essa doença atinge principalmente indivíduos com alimentação inadequada como, por exemplo, alcoolistas crônicos, portadores de doença gastrointestinal (Filgueiras et al, 2011).…”

Section: Pelagra E a Deficiência De Niacina Ou áCido Nicotínico (Vita...unclassified

Prejuízo na absorção de nutrientes pela ingestão de álcool: uma revisão

Roth¹,

Meira²,

Kolitski³

et al. 2020

RSD

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Alcohol use disorders are among the most prevalent mental disorders in Brazil and worldwide. This substance is related to the low bioavailability of some important nutrients. In this sense, the present study aimed to relate the impairment in the absorption of nutrients with alcohol consumption. This is a simple literature review, with a search for the topic in databases and analysis of articles from the last 19 years. It has been observed that alcohol can impair intestinal absorption and increase renal excretion of folate. Some vitamins like vitamin A and C, B6, niacin have their absorption impaired by alcohol consumption. The deficiency of some vitamins and minerals, such as some of the complex B and magnesium, mineral that plays a crucial role in various reactions of the body. In this way, it was observed that the ingestion of alcohol, especially regular alcohol, has a direct association with losses in bioavailability and nutrient absorption.

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Lipomatose simétrica benigna e pelagra, associadas ao alcoolismo

Cited by 8 publications

References 4 publications

miR-125a-3p and miR-483-5p promote adipogenesis via suppressing the RhoA/ROCK1/ERK1/2 pathway in multiple symmetric lipomatosis

miR-125a-3p and miR-483-5p promote adipogenesis via suppressing the RhoA/ROCK1/ERK1/2 pathway in multiple symmetric lipomatosis

Syndrome in Question

Prejuízo na absorção de nutrientes pela ingestão de álcool: uma revisão

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