Hiperplasia sebácea cutânea: estudo piloto para a correlação da doença com hormônios androgênios

Tagliolatto, Sandra; Alchorne, Maurício Mota de Avelar; Enokihara, Mauro

doi:10.1590/s0365-05962011000500009

Cited by 6 publications

(2 citation statements)

References 27 publications

(47 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The development and function of the sebaceous gland in the fetus and neonate are regulated by maternal androgen and the synthesis of endogenous steroids, which lead to increased sebaceous excretion within a few hours after birth. This fact can cause excessive proliferation and superficial visualization at the beginning of extrauterine life 22 . There was no statistical significance between sebaceous hyperplasia and maternal gestational intercurrences, which differs from other studies 11 .…”

Section: Discussioncontrasting

confidence: 57%

Dermatoses in the Early Neonatal Period: Their Association With Neonatal, Obstetric and Demographic Variables

Krüger

Sinkos

Uhry

et al. 2019

Rev. paul. pediatr.

View full text Add to dashboard Cite

Objective: To evaluate the prevalence of neonatal dermatoses in the early neonatal period and to associate them with neonatal, demographic and obstetric variables.Methods: A cross-sectional study with neonates and their respective mothers, who were hospitalized in a public maternity hospital in Curitiba, PR, Brazil. Data collection was performed using information present in the medical records and a physical examination of the newborn during the period between April 2015 and May 2016.Results: 350 neonates were evaluated. 54.8% were male, and 94.8% (332/350) presented a dermatosis. Among them, 84.6% had, concomitantly, two or more dermatoses. A total of 23 types of dermatoses were diagnosed. The most prevalent were: sebaceous hyperplasia (66%); fluff (42.6%); and salmon patches (41.4%). The mean age of the mothers was 24.9±4.9 years old, and they were predominately white (57.7%). Vernix caseosa was associated with the female gender (p=0.034). Nonwhite mothers were associated with genital hyperpigmentation (p=0.03) and Mongolian spots (p=0.001). Physiological flaking was associated with cesarean deliveries (p=0.03) and a gestational age of over 40 weeks (p=0.054). Salmon patches was associated with primiparity (p=0.0001).Conclusions: There was a high prevalence of neonatal dermatosis in the studied population. Each newborn had, on average, three different dermatoses. Dermatosis in neonates was associated with primiparity, nonwhites, a gestational age of over 40 weeks, and the sex of the newborn.

show abstract

Section: Discussioncontrasting

confidence: 57%

Dermatoses in the Early Neonatal Period: Their Association With Neonatal, Obstetric and Demographic Variables

Krüger

Sinkos

Uhry

et al. 2019

Rev. paul. pediatr.

View full text Add to dashboard Cite

show abstract

“…These data collectively suggest that AR has an anti-proliferative function. Whether human SG hyperplasia is also linked to androgens is debated (Plewig and Kligman, 1978; Pochi et al., 1979; Tagliolatto et al., 2011). …”

Section: Resultsmentioning

confidence: 99%

c-MYC-Induced Sebaceous Gland Differentiation Is Controlled by an Androgen Receptor/p53 Axis

et al. 2013

View full text Add to dashboard Cite

SummaryAlthough the sebaceous gland (SG) plays an important role in skin function, the mechanisms regulating SG differentiation and carcinoma formation are poorly understood. We previously reported that c-MYC overexpression stimulates SG differentiation. We now demonstrate roles for the androgen receptor (AR) and p53. MYC-induced SG differentiation was reduced in mice lacking a functional AR. High levels of MYC triggered a p53-dependent DNA damage response, leading to accumulation of proliferative SG progenitors and inhibition of AR signaling. Conversely, testosterone treatment or p53 deletion activated AR signaling and restored MYC-induced differentiation. Poorly differentiated human sebaceous carcinomas exhibited high p53 and low AR expression. Thus, the consequences of overactivating MYC in the SG depend on whether AR or p53 is activated, as they form a regulatory axis controlling proliferation and differentiation.

show abstract

Effect of hemp fiber on UVB-induced epidermal cell proliferation and PCNA expression

et al. 2017

View full text Add to dashboard Cite

Hiperplasia sebácea cutânea: estudo piloto para a correlação da doença com hormônios androgênios

Cited by 6 publications

References 27 publications

Dermatoses in the Early Neonatal Period: Their Association With Neonatal, Obstetric and Demographic Variables

Dermatoses in the Early Neonatal Period: Their Association With Neonatal, Obstetric and Demographic Variables

c-MYC-Induced Sebaceous Gland Differentiation Is Controlled by an Androgen Receptor/p53 Axis

Effect of hemp fiber on UVB-induced epidermal cell proliferation and PCNA expression

Contact Info

Product

Resources

About