Dermatite verrucosa de Pedroso e Gomes (Cromomicose): 90 anos depois, ainda entre nós

Criado, Paulo Ricardo; Valente, N. Y. S.; Brandt, Hebert Roberto Clivati; Belda, Walter; Halpern, Ilana

doi:10.1590/s0365-05962010000100018

Cited by 6 publications

(5 citation statements)

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“… 17 Other findings include suppurative and granulomatous reactions, sclerotic bodies and acanthosis with transepidermal fungal elimination. 3 , 18 - 22 In this study, the intensity and type of histological response were modified according to patient and therapeutic phase. Before treatment, there was a tendency to an exuberant inflammatory condition, epidermis with hyperkeratosis, parakeratosis, leukocyte crusts, Malpighian layer acanthosis, spongiosis, neutrophil and eosinophil exocytosis and microabscesses.…”

Section: Discussionmentioning

confidence: 99%

Chromoblastomycosis: tissue modifications during itraconazole treatment

Peretti

Neto

Olandoski

2017

An. Bras. Dermatol.

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BackgroundHistological and mycological changes during itraconazole use have not been totally established in chromoblastomycosis.ObjectivesTo evaluate tissue modifications in chromoblastomycosis carriers under itraconazole treatment.MethodsA histological retrospective study of 20 cases of chromoblastomycosis seen at the university hospital at the south of Brazil, during itraconazole 400 mg daily treatment. Patients were classified into two groups: plaque or tumor lesions, and underwent periodic evaluations every four months during three years. Hematoxylin-eosin stain was used to analyze epidermal modifications, inflammatory infiltrate and fibrosis, and Fontana-Masson stain for parasite evaluation.ResultsFontana-Masson stain was superior to hematoxylin-eosin stain in fungal count in the epidermis (mean difference=0.14; p<0.05). The most distinct mycosis tissue responses were registered in the dermis. Epidermal thinning, granulomatous infiltrate decrease or disappearance, fibrosis increase and quantitative/morphological changes occurred during treatment.Study limitationsPatients could not be located to have their current skin condition examined.ConclusionParasitic and tissue changes verified in this study can reflect the parasite-host dynamics under itraconazole action.

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Section: Discussionmentioning

confidence: 99%

Chromoblastomycosis: tissue modifications during itraconazole treatment

Peretti

Neto

Olandoski

2017

An. Bras. Dermatol.

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“…1,4 Similar to voriconazole, posaconazole and isavuconazole seem to be potential candidates for use in treatment of chromoblastomycosis, for they present the lowest minimal inhibitory concentrations in studies with specimens of Fonsecaea . However, only posaconazole is commercially available in Brazil since 2015.…”

Section: Discussionmentioning

confidence: 99%

Response of chromoblastomycosis to voriconazole

Lima

Sacht

Paula

et al. 2016

An. Bras. Dermatol.

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Chromoblastomycosis is a chronic fungal infection of the epidermis, dermis and subcutaneous tissue, in which the most common etiologic agent in Brazil is Fonsecaea pedrosoi. In more advanced cases we found many difficulties in their treatment, and therefore, we report a case of extensive and severe chromoblastomycosis, with therapeutical failure of first choice treatments, but good response to voriconazole.

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“…However, there are reports of epidemiological and microbiological research that certify the presence of this disease in nearly the entire country, 7,[12][13][14][15][16][17][18][19][20][21] with an estimated prevalence of 0.098 cases per 1,000,000 inhabitants. 11 In the scientific literature, there are few case reports of chromoblastomycosis from the state of Mato Grosso, in central-western Brazil.…”

Section: Introductionmentioning

confidence: 99%

“…10 , 11 In Brazil, the actual disease incidence and prevalence are largely unknown, as it is not mandatory to notify this disease. However, there are reports of epidemiological and microbiological research that certify the presence of this disease in nearly the entire country, 7 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 with an estimated prevalence of 0.098 cases per 1,000,000 inhabitants. 11 …”

Section: Introductionmentioning

confidence: 99%

Molecular epidemiology and clinical‐laboratory aspects of chromoblastomycosis in Mato Grosso, Brazil

Guevara

Nery

Melhem

et al. 2022

Mycoses

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Introduction Chromoblastomycosis is a disease caused by melanized fungi, primarily belonging to the genera Fonsecaea and Cladophialophora, mainly affecting individuals who are occupationally exposed to soil and plant products. This research aimed to determine the clinical, epidemiological and laboratory characteristics of chromoblastomycosis in the state of Mato Grosso, Brazil. Materials and Methods Patients diagnosed with chromoblastomycosis treated at the Júlio Müller University Hospital, Cuiabá, Brazil, from January 2015 to December 2020, whose isolates were preserved in the Research Laboratory of the Faculty of Medicine of the Federal University of Mato Grosso. Isolates were identified by partly sequencing the Internal Transcribed Spacer (ITS) and β‐tubulin (BT2) loci. AFLP fingerprinting was used to explore the genetic diversity. Susceptibility to itraconazole, voriconazole, 5‐fluorocytosine, terbinafine and amphotericin B was determined by the broth microdilution technique. Results Ten patients were included, nine were male (mean age = 64.1 years). Mean disease duration was 8.6 years. Lesions were mainly observed in the lower limbs. Predominant clinical forms were verrucous and scarring. Systemic arterial hypertension and type II diabetes mellitus were the predominant comorbidities. Leprosy was the main concomitant infectious disease. Fonsecaea pedrosoi was the unique aetiological agent identified with moderate genetic diversity (H = 0.3934–0.4527; PIC = 0.3160–0.3502). Antifungal agents with the highest activity were terbinafine, voriconazole and itraconazole. Conclusion Chromoblastomycosis is affecting the poor population in rural and urban areas, mainly related to agricultural activities, with F. pedrosoi being the dominant aetiologic agent. All isolates had low MICs for itraconazole, voriconazole and terbinafine, confirming their importance as therapeutic alternatives for chromoblastomycosis.

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Dermatite verrucosa de Pedroso e Gomes (Cromomicose): 90 anos depois, ainda entre nós

Cited by 6 publications

References 0 publications

Chromoblastomycosis: tissue modifications during itraconazole treatment

Chromoblastomycosis: tissue modifications during itraconazole treatment

Response of chromoblastomycosis to voriconazole

Molecular epidemiology and clinical‐laboratory aspects of chromoblastomycosis in Mato Grosso, Brazil

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