Associação entre acrocórdons e resistência à insulina

Abstract

The presence of multiple skin tags was strongly associated with insulin resistance irrespective of other risk factors.

Association of acanthosis nigricans and skin tags with insulin resistance

“…51 Crook reported four patients with multiple skin tags, and all patients had increased levels of serum triglycerides and reduced HDL cholesterol levels. 53 Multiple skin tags (more than 8 lesions) were more sensitive than AN when identifying changes in carbohydrate metabolism, but less specific. 52 Therefore, presence of skin tags is a clue for detection of hyperinsulinemia, which is considered the foundation for syndrome X.…”

As principais alterações dermatológicas em pacientes obesos

“…Early identification of patients with insulin resistance may have primary preventive role 39 . Papillomas are small, generally located on the sides of the neck, armpits, upper chest and eyelids of patients middle-aged or elderly.…”

The frequency of metabolic syndrome in patients with acrochordons

“…In a study performed by Sudy et al, 11 it was reported that eight or more acrochordons are related to basal and postprandial hyperinsulinemia and postprandial hyperglycemia, and that multiple acrochordons are more sensitive, but less specific than acanthosis nigricans in the evaluation of glucose/insulin metabolism. In the study published by Tamega et al, 12 it was also reported that acrochordons had been associated with HOMA-IR, TG, BMI, waist/ hip ratio (WHR) and the presence of DM. In another study, Agarwal et al 19 found that the frequencies of overt DM and IGT were, respectively, 30.5% and 10.1% in patients with acrochordons, and that there was no correlation between glucose intolerance and the localization, size, color, and number of acrochordons.…”

“…In diabetic patients with sign of IR, the frequencies of acrochordons and acanthosis nigricans were reported as 26.2% and 5%, respectively 7 . In many studies, conflicting results have been reported, as to the relationship among acrochordons, seborrheic keratosis, pseudoacanthosis nigricans, DM, IR and MetS, [8][9][10][11][12] and MetS components rather than the presence of MetS have been evaluated. As well as the limited number of literature including only two studies that investigated the presence of MetS in patients with acrochordons, 10,13 we also aimed at evaluating the presence of MetS in patients with acrochordons under the criteria of NCEP-ATP III.…”

“…Since then, limited data targeting to investigate the relationship between acrochordons and the components of MetS have been published with conflicting results [8][9][10][11][12][13]18 . In a study performed by Sudy et al, 11 it was reported that eight or more acrochordons are related to basal and postprandial hyperinsulinemia and postprandial hyperglycemia, and that multiple acrochordons are more sensitive, but less specific than acanthosis nigricans in the evaluation of glucose/insulin metabolism.…”