2009
DOI: 10.1590/s0365-05962009000600022
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Abstract: A hidradenite supurativa é doença inflamatória de difícil tratamento. Recentemente, a terapia anti-TNF alfa, com anticorpos monoclonais ("terapia biológica"), tem sido apontada como uma alternativa. No entanto, ensaios clínicos avaliando a eficácia destas drogas na hidradenite supurativa, ainda não foram publicados. Apresentamos um caso no qual o uso do infliximabe não resultou em melhora clínica expressiva.

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Cited by 13 publications
(9 citation statements)
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“…1,3,6 Acne tetrad or follicular occlusion tetrad is composed of acne conglobata, hidradenitis suppurativa, pilonidal cysts and folliculitis abscedens. 9 In pseudo-acne fulminans there are skin ulcerations with hemorrhagic crusts in seborrheic areas, without systemic involvement. This is due to the drug ability to determine alterations in the desmosomes, in the collagen and in vascular proliferation.…”
Section: Discussionmentioning
confidence: 99%
“…1,3,6 Acne tetrad or follicular occlusion tetrad is composed of acne conglobata, hidradenitis suppurativa, pilonidal cysts and folliculitis abscedens. 9 In pseudo-acne fulminans there are skin ulcerations with hemorrhagic crusts in seborrheic areas, without systemic involvement. This is due to the drug ability to determine alterations in the desmosomes, in the collagen and in vascular proliferation.…”
Section: Discussionmentioning
confidence: 99%
“…In some cases in which control of the condition has proven difficult, oral isotretinoin may be used and, more recently, inhibitors of tumor necrosis factor-alpha production have been used in severe cases; however, results have not always been satisfactory. 6 Case reports and series of cases have suggested that infliximab may be an effective treatment for HS, although the drug has yet to be approved for this purpose. [6][7][8][9][10] In the case reported here, the patient is female and the condition began at puberty and was confined exclusively to the inframammary region.…”
Section: Discussionmentioning
confidence: 99%
“…6 Case reports and series of cases have suggested that infliximab may be an effective treatment for HS, although the drug has yet to be approved for this purpose. [6][7][8][9][10] In the case reported here, the patient is female and the condition began at puberty and was confined exclusively to the inframammary region. The treatment proposed was the systemic use of sulfamethoxazole-trimethoprim with a maintenance dose and gradual withdrawal, in addition to topical antibiotics.…”
Section: Discussionmentioning
confidence: 99%
“…Only those 15 patients who were initially allocated to infliximab were included. Evidence levels B and C were found in seven 19,43–48 and 34 studies, 49–82 respectively. One study compared the effect of infliximab with another treatment, namely adalimumab 19 .…”
mentioning
confidence: 97%
“…In four papers, in addition to infliximab, patients received methotrexate, which might have prevented the formation of autoantibodies 45,49,60,64 . Simultaneously to infliximab, patients were treated with azathioprine in two studies, 70,72 prednisolone in one study, 77 prednisolone and ciclosporin in one study 68 and with oral azathioprine and methylprednisolone in one study 71 …”
mentioning
confidence: 99%