Síndrome tilose hereditária e câncer de esôfago

Souza, Camila Alves de; Santos, Allan da Costa; Santos, Lennon da Costa; Carneiro, Artur Leonel

doi:10.1590/s0365-05962009000500014

Cited by 5 publications

(2 citation statements)

References 5 publications

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“…It has since been determined that the two Liverpool families are in fact distant kindreds [ 3 ]. Similar but smaller pedigrees have been reported from Germany [ 4 ] the United States [ 5 ] Finland [ 6 ] Spain [ 7 ] and Brazil [ 8 ]. The prevalence of the disorder in the general population is unknown, but is likely to be less than one in 1,000,000.…”

Section: Epidemiologysupporting

confidence: 72%

Tylosis with oesophageal cancer: Diagnosis, management and molecular mechanisms

Ellis

Risk

Maruthappu

et al. 2015

Orphanet J Rare Dis

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Tylosis (hyperkeratosis palmaris et plantaris) is characterised by focal thickening of the skin of the hands and feet and is associated with a very high lifetime risk of developing squamous cell carcinoma of the oesophagus. This risk has been calculated to be 95 % at the age of 65 in one large family, however the frequency of the disorder in the general population is not known and is likely to be less than one in 1,000,000. Oesophageal lesions appear as small (2–5 mm), white, polyploid lesions dotted throughout the oesophagus and oral leukokeratosis has also been described. Although symptoms of oesophageal cancer can include dysphagia, odynophagia, anorexia and weight loss, there may be an absence of symptoms in early disease, highlighting the importance of endoscopic surveillance in these patients. Oesophageal cancer associated with tylosis usually presents in middle to late life (from mid-fifties onwards) and shows no earlier development than the sporadic form of the disease. Tylosis with oesophageal cancer is inherited as an autosomal dominant trait with complete penetrance of the cutaneous features, usually by 7 to 8 years of age but can present as late as puberty. Mutations in RHBDF2 located on 17q25.1 have recently been found to be causative. A diagnosis of tylosis with oesophageal cancer is made on the basis of a positive family history, characteristic clinical features, including cutaneous and oesophageal lesions, and genetic analysis for mutations in RHBDF2. The key management goal is surveillance for early detection and treatment of oesophageal dysplasia. Surveillance includes annual gastroscopy with biopsy of any suspicious lesion together with quadratic biopsies from the upper, middle and lower oesophagus. This is coupled with dietary and lifestyle modification advice and symptom education. Symptomatic management of the palmoplantar keratoderma includes regular application of emollients, specialist footwear and early treatment of fissures and super-added infection, particularly tinea pedis. More specific treatment for the thick skin is available in the form of oral retinoids, which are very effective but commonly produce side effects, including nasal excoriation and bleeding, hypercholesterolaemia, and abnormal liver function tests. Genetic counselling can be offered to patients and family members once a family history has been established. The prognosis of tylosis with oesophageal cancer is difficult to determine due to the limited number of affected individuals. In the last 40 years of surveillance, five out of six cases of squamous oesophageal cancer in the Liverpool family were detected endoscopically and were surgically removed. Four of five patients had stage 1 disease at presentation and remain alive and well more than 8 years later. This suggests that the presence of a screening program improves prognosis for these patients.

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Section: Epidemiologysupporting

confidence: 72%

Tylosis with oesophageal cancer: Diagnosis, management and molecular mechanisms

Ellis

Risk

Maruthappu

et al. 2015

Orphanet J Rare Dis

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“…Tylosis with esophageal cancer was first reported in two large families from Liverpool [1, 2] and later found that both families are related distantly [3]. Smaller heritage lines were reported from Germany [4], United States [5], Finland [6], Spain [7] and Brazil [8]. We describe another family from USA with screening endoscopic findings of one of the family members.…”

Section: Introductionmentioning

confidence: 97%

Uncommon Endoscopic Findings in a Tylosis Patient: A Case Report

et al. 2019

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Palmoplantar tylosis is a focal non epidermolytic palmoplantar hyperkeratosis and is associated with a very high lifetime risk of developing squamous cell carcinoma of the esophagus (OSCC). It is generally inherited as an autosomal dominant trait with complete penetrance involving the RHBDF2 gene located on 17q25.1. The data regarding endoscopic appearance of the mucosa in patients with tylosis before development of cancer is limited. Surveillance endoscopy is recommended in family members which include annual esophagogastroscopy with biopsy of suspicious lesion with quadratic biopsies from upper, middle and lower esophagus. We describe characteristic endoscopy findings in a tylosis with no evidence of cancer. Prospective documentation of endoscopic findings of similar mucosal changes and disease process to establish a better screening protocol and supplemental intervention with agents like carotenoids (beta-carotene, alpha-carotene, lycopene, beta-cryptoxanthin, lutein, and zeaxanthin) may delay the progression and possibly revert to normal.

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