Utilização da terapia ultra-sônica de baixa intensidade na redução da lipodistrofia ginecóide: uma terapia segura ou risco cardiovascular transitório? Um estudo pré-clínico

Gonçalves, Washington Luiz Silva; Cirqueira, João Paulo; Soares, Luciana Saloto; Bissoli, Nazaré Souza; Moysés, Margareth Ribeiro

doi:10.1590/s0365-05962005001000015

Cited by 9 publications

(13 citation statements)

References 24 publications

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“…Likewise, in the evaluation of body composition, there was a significant reduction in the obesity index (Lee's Index) among the DLC-treated rats, possibly due to the reduction of inguinal subcutaneous fat (lipolysis), effects already described in nonobese animals 6,8 . Nevertheless, it was interesting to observe the reductions in the RET and PR fat deposits ( fat pads) without any changes in the EP fat pad in healthy males, considering the distance between the epididymal and perirenal fat deposits, as the former is anatomically closer to the US-stimulated areas than the perirenal fat pad.…”

Section: Discussionmentioning

confidence: 59%

“…The broad use of ultrasound therapy in several health branches made it possible to identify several different biological effects of low-intensity ultrasound (US) in a number of tissues [1][2][3][4][5][6][7][8][9][10][11][12][13][14] , namely fibrinolytic effects 9 , as well as thrombolytic 10 , lipolytic 6,8 , angiogenic 13 , enzymatic 5,14 , and oxidative effects 13 , as well as synergic in vasoactive drugs 4,5 , to name but a few 3,11 . All of these effects are directly associated with the dosages used (power, frequency, time-length), and also with the responsiveness of the biological tissue exposed, i.e.…”

Section: Introductionmentioning

confidence: 99%

“…Current studies show that US applications in usual dosages (1 and 3 MHz) in physical therapy 3,8 and in clinical diagnosis 1 , although not unsafe for daily practice, should not be taken as a risk-free tool, because it only uses small variations in frequency, power, and time -i.e. dosages and ways to apply them -to bring about local changes in the biological tissue exposed [1][2][3][4][5][6][7][8][9][10][11][12][13][14] .…”

Section: Introductionmentioning

confidence: 99%

“…dosages and ways to apply them -to bring about local changes in the biological tissue exposed [1][2][3][4][5][6][7][8][9][10][11][12][13][14] .…”

Section: Introductionmentioning

confidence: 99%

“…Paradoxically, the beneficial findings of low-intensity ultrasound therapy in various fields 2,5,7,10,11 are rarely found in clinical studies or in robust experimental research dealing with the local and systemic metabolic risks of fat mobilization and release triggered by the use of dermosonic lipoclasis (DLC), lysis of subcutaneous adipose cells by LIUST, seeing that this is broadly used in surgical, aesthetic, and cosmeceutical treatments 4,8,10,23,25 . Therefore, the goal of this study was to evaluate the implications of DLC on the energetic metabolism and body fat distribution of healthy rats, by means of measurements such as weight, length, plasma biochemistry, body composition (obesity index) 26 and bilateral lipectomy of the fat depositions 27 .…”

Section: Introductionmentioning

confidence: 99%

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Implicações da lipoclasia dermossônica no metabolismo energético e na composição corporal de ratos Wistar saudáveis

Gonçalves

Cirqueira

Abreu

et al. 2009

Rev. bras. fisioter.

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Implications of dermosonic lipoclasisfor energy metabolism and body composition of healthy Wistar rats Implicações da lipoclasia dermossônica no metabolismo energético e na composição corporal de ratos Wistar saudáveis Gonçalves WLS, Cirqueira JP, Abreu GR, Moysés MR AbstractObjectives: To investigate the implications of Dermosonic lipoclasis (DLC), i.e. lipolysis on subcutaneous white adipose tissue induced by ultrasound, for the energy metabolism and body composition of healthy rats. Methods: Twenty four-month-old male Wistar rats weighting ±380g were randomly divided into two groups: 1) sham control (SC) and 2) low-intensity ultrasound therapy (LIUST). For 10 days, after sedation with 3% vaporized halothane, the animals underwent LIUST (I SATA =3MHz, 1 Wcm -2 , pulsed mode 2:8ms, 30% cycles for 3 minutes) in the infra-abdominal and inguinal regions. Weight measurements, naso-anal length and metabolic parameters (food and water intake and excretion) were monitored during the study. At the end of the treatment, blood samples were collected for biochemical analyses. Retroperitoneal (RET), perirenal (PR), epididymal (EP) and inguinal (ING) adiposity was evaluated. HOMA-IR (homeostasis model assessment) was calculated to estimate insulin resistance. For statistical analyses, the Student t test, ANOVA and the Tukey test were used, and differences were established as p<0.05. Results: Regarding body weight, the SC group (384±9g) did not show any changes, while the treated group (337±2g) showed reductions (p<0.01). This was also seen in relation to food intake: (25±1g) vs. (21±1g). There were also reductions (p<0.05) in the RET, PR and ING fat-pads, obesity index, triglyceride levels and plasma lipoprotein levels. Hyperinsulinemia without changes in glycemia characterized a state of insulin resistance, which was confirmed by HOMA-IR. Conclusions: DLC reduced the food intake and body weight and modified the fat deposition in the RET, PR and ING stores in rats. This changed the lipid profile to produce a significant state of insulin resistance.Key words: ultrasound therapy; dermosonic lipoclasis; adipose tissue; energy metabolism; insulin resistance. ResumoObjetivos: Investigar as implicações da lipoclasia dermossônica (LCD), lipólise do tecido adiposo branco subcutâneo induzido por ultrassom (US), no metabolismo energético e na composição corporal de ratos saudáveis. Métodos: Utilizaram-se 20 ratos Wistar saudáveis, com 4 meses de idade, pesando ±380g, divididos aleatoriamente em 2 grupos: 1) controle-sham (CS), 2) terapia ultrassônica de baixa intensidade (TUSBI). Durante 10 dias, após sedação (halotano-3% vaporizado), os animais eram submetidos à TUSBI (I SATA =3MHz, 1W.cm -2 , modo pulsado 2:8ms, ciclo de 30% por 3 minutos) em região infra-abdominal e inguinal. Medidas de peso, comprimento naso-anal e parâmetros metabólicos (ingestão e excreção) foram controlados durante o estudo. Ao final do tratamento, amostras de sangue foram coletadas para dosagens bioquímicas, e então avaliadas adiposidades retroperitoneal (RET...

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Section: Discussionmentioning

confidence: 59%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…dosages and ways to apply them -to bring about local changes in the biological tissue exposed [1][2][3][4][5][6][7][8][9][10][11][12][13][14] .…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Implicações da lipoclasia dermossônica no metabolismo energético e na composição corporal de ratos Wistar saudáveis

Gonçalves

Cirqueira

Abreu

et al. 2009

Rev. bras. fisioter.

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Correlação entre o ângulo de curvatura da lordose lombar e o grau de Lipodistrofia Ginóide (celulite) em mulheres assintomáticas

Milani¹

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A minha tia Nilda e minha avó Guilhermina, pela oração e amor. Ao meu irmão, Luiz Guilherme pelas dicas e ajuda de informática. A minha amiga Carla Sonsino, pela colaboração, palpites, carinho e ombro amigo nos momentos de estresse. A minha amiga Ana Rosa Visnardi, também pelo ombro amigo e pela paciência. A minha amiga Patrícia Jundi, pelas conversas no trânsito, apoio e ajuda em vários momentos. Ao meu namorado e amigo, Leandro Antônio, pela compreensão da ausência e pelo amor. Ao Dr. Al'Dayr, pela grande ajuda e pelos ensinamentos. As 50 voluntárias, amigas ou desconhecidas, pois sem elas esse trabalho não seria possível. Aos funcinários do HU pela competência e boa vontade. A minha orientadora, Profa Silvia Maria Amado João por ter aceitado o desafio de pesquisar uma área ainda pouco explorada na fisioterapia. A fisioterapeuta Estela Adriana Farah, pela grande colaboração no início do trabalho. A Profa Dra Maria Silvia Mariane Pires de Campos pela "sementinha plantada", pela amizade e colaboração. A todas minhas amigas por compreenderem minha aunsência e por terem, em algum momento, dividido comigo cada passo conquistado.

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Análise histológica em tecido epitelial sadio de ratos Wistar (in vivo) irradiados com diferentes intensidades do ultrassom

De¹,

Maciel²,

Zuanon³

et al. 2010

Rev. bras. fisioter.

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Utilização da terapia ultra-sônica de baixa intensidade na redução da lipodistrofia ginecóide: uma terapia segura ou risco cardiovascular transitório? Um estudo pré-clínico

Cited by 9 publications

References 24 publications

Implicações da lipoclasia dermossônica no metabolismo energético e na composição corporal de ratos Wistar saudáveis

Implicações da lipoclasia dermossônica no metabolismo energético e na composição corporal de ratos Wistar saudáveis

Correlação entre o ângulo de curvatura da lordose lombar e o grau de Lipodistrofia Ginóide (celulite) em mulheres assintomáticas

Análise histológica em tecido epitelial sadio de ratos Wistar (in vivo) irradiados com diferentes intensidades do ultrassom

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