Urticária

Criado, Paulo Ricardo; Criado, Roberta Fachini Jardim; Maruta, Celina Wakisaka; Martins, José Eduardo; Rivitti, Evandro A.

doi:10.1590/s0365-05962005000700008

Cited by 15 publications

(18 citation statements)

References 37 publications

(74 reference statements)

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“…18 Recently some authors showed that the activated fraction of C5 complement, when bound to its receptor on the membrane of neutrophils, activate these cells and begin to express tissue factor in their cytoplasm membranes. Moreover, C5a can induce thrombosis by increasing TF expression on endothelial cells and monocytes in mice.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of D-dimer serum levels among patients with chronic urticaria, psoriasis and urticarial vasculitis

Criado

Antinori

Maruta³

et al. 2013

An. Bras. Dermatol.

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BACKGROUND It has been demonstrated that neutrophils, eosinophils and monocytes, under appropriated stimulus, may express tissue factor and therefore, activate the extrinsic pathway of coagulation. We performed a transversal and case-control study of patients with chronic urticaria and patients with psoriasis, in our outpatient clinic to evaluate the production of D-dimer. OBJECTIVE To evaluate D-dimer serum levels in patients with chronic urticaria and its possible correlation with disease activity. PATIENTS AND METHODS The study was conducted from October 2010 until March 2011. We selected 37 consecutive patients from our Allergy Unit and Psoriasis Unit, and divided them into three groups for statistical analysis: (i) 12 patients with active chronic urticaria (CU); (ii) 10 patients with chronic urticaria under remission and (iii) 15 patients with psoriasis (a disease with skin inflammatory infiltrate constituted by neutrophils, lymphocytes and monocytes). Another five patients with urticarial vasculitis were allocated in our study, but not included in statistical analysis. The serum levels of D-dimer were measured by Enzyme Linked Fluorescent Assay (ELFA), and the result units were given in ng/ml FEU. RESULTS Patients with active chronic urticaria had the highest serum levels of D-dimer (p<0.01), when compared to patients with CU under remission and the control group (patients with psoriasis). CONCLUSIONS Patients with active chronic urticaria have higher serum levels of D-dimer, when compared to patients with chronic urticaria under remission and patients with psoriasis. We found elevated serum levels of D-dimer among patients with urticarial vasculitis.

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Section: Discussionmentioning

confidence: 99%

Evaluation of D-dimer serum levels among patients with chronic urticaria, psoriasis and urticarial vasculitis

Criado

Antinori

Maruta³

et al. 2013

An. Bras. Dermatol.

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“…23 The wide availability of second-generation H 1 antihistamines in the public health system by competent authorities should be reevaluated due to their greater clinical safety in adults and children, the frequent need to associate various H 1 antihistamines at habitual doses to control CU 64 , their posology comfort, and the existence of several generic pharmaceutical preparations in the Brazilian market.…”

mentioning

confidence: 99%

Histamina, receptores de histamina e anti-histamínicos: novos conceitos

Criado

Maruta

et al. 2010

An. Bras. Dermatol.

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Drugs with antihistamine action are the most commonly prescribed medication in daily dermatologic practice, both to adults and children. This article addresses new concepts of the role of histamine receptors (H1 receptors) and discusses the anti-inflammatory effects of these drugs. Second generation antihistamines differs from first generation because of their high specificity and affinity for peripheral H1-receptors. Second generation antihistamines are also less likely to produce sedation because they have less effect on the central nervous system. Although the efficacy of the various H1-antihistamines in the treatment of allergic patients is similar, even when comparing first-and second-generation drugs, these drugs are still very different in terms of their chemical structure, pharmacology and toxic properties. Consequently, knowledge of their pharmacokinetic and pharmacodynamic characteristics is essential for a better medical care, especially that offered to pregnant women, children, the elderly, and patients with comorbidities. Keywords: Histamine; Histamine H1 receptors antagonists; Histamine receptors; Histamine release; Histamine H1 antagonists, non-sedating; Receptors, histamine H1Resumo: As drogas com ação anti-histamínica estão entre as medicações mais comumente prescritas na prática dermatológica diária, tanto em adultos como em crianças. Este artigo aborda os novos conceitos da função dos receptores de histamina (receptores H1) e discute os efeitos anti-inflamatórios dessas drogas. A segunda geração de anti-histamínicos difere da primeira geração devido a sua elevada especificidade e afinidade pelos receptores H1 periféricos e devido a seu menor efeito no sistema nervoso central, tendo como resultado menores efeitos sedativos. Embora a eficácia dos diferentes anti-histamínicos H1 (anti-H1) no tratamento de doentes alérgicos seja similar, mesmo quando se comparam anti-H1 de primeira e de segunda geração, eles são muito diferentes em termos de estrutura química, farmacologia e propriedades tóxicas. Consequentemente o conhecimento de suas características farmacocinéticas e farmacodinâmicas é importante para a melhor prática médica, especialmente em gestantes, crianças, idosos e doentes com comorbidades. Palavras-chave: Antagonistas da histamina H1 não sedativos; Antagonistas dos receptores H1 de histamina; Histamina; Liberação de histamina; Receptores de histamina; Receptores de histamina H1

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“…First generation antihistamines have poor H1 receptor selectivity, and cross the blood brain barrier, whereas second and third generation antihistamines are highly selective for the H1 receptor, and do not cross the blood brain barrier. [10] Third generation antihistamines are the active enantiomer (levocetirizine) or metabolite (desloratadine and fexofenadine) derivatives of second generation drugs (cetirizine, loratadine, terfenadine). They intended to have increased efficacy with fewer adverse drug reactions.Some antihistamines, such as fexofenadine, have a strong interaction with grapefruit juice.…”

Section: Antihistaminesmentioning

confidence: 99%

“…[11] The overall safety profiles of antihistamines such as levocetirizine and desloratadine were similar to placebo in children and adults, which had been confirmed in randomized, placebo-controlled. [10] The Role of Antihistamines in Allergic Rhinitis and Asthma H1-antihistamines are widely used in the treatment of allergic and nonallergic disorders. [11] In patients with allergic rhinitis, second generation H1-antihistamines prevent and relieve the sneezing, itching, rhinorrhea, and nasal congestion that characterize the early and the late response to allergen.…”

Section: Antihistaminesmentioning

confidence: 99%

“…[11] In patients with allergic rhinitis, second generation H1-antihistamines prevent and relieve the sneezing, itching, rhinorrhea, and nasal congestion that characterize the early and the late response to allergen. [10] In the treatment of allergic rhinitis, oral H1-antihistamines are more efficacious than chromones; but less efficacious than nasal glucocorticoids. [11] In a study done comparing nasal H1-antihistamine and nasal glucocorticoid in patients with allergic and nonallergic rhinitis, azelastine was as effective as triamcinolone in improving nasal symptoms; sleep symptoms and quality of life.…”

Section: Antihistaminesmentioning

confidence: 99%

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Role of leukotriene antagonists and antihistamines in treatment of allergic rhinitis and asthma comorbidity

Baççıoğlu¹

2013

J Med Updates

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Allergy is a reaction with inflammatory cell infiltration in the target organ which allergen has been found to cause the pathology. [1,2] Allergens cause an immunoglobulin (Ig) E dependent reaction characterized by an early and late phase reaction. Histamine is released after 15 min of exposure to allergen, whereas leukotriene is increased in the AbstractLeukotriene receptor antagonists and antihistamines are efficient in reducing symptoms of allergic rhinitis and asthma when used alone or in combination. In patients with allergic rhinitis, H1-antihistamines prevent and relieve the sneezing, itching, rhinorrhea, and nasal congestion that characterize the early and the late response to allergen. H1-antihistamines are not medications of choice in asthmatic patients, but controlling rhinitis will improve asthma concomitantly. Leukotriene antagonist such as montelukast may be an alternative treatment for mild persistent asthma as monotherapy where inhaled corticosteroid cannot be administered or alternative to long-acting beta agonist as an add-on therapy to ICS for moderate to severe persistent asthma. Although montelukast is an effective drug in allergic rhinitis indicated as monotherapy, but widely recommended as adjunct to antihistamine or intranasal corticosteroid. Antileukotriene agents are also widely used in the treatment of pediatric asthma. In children, maintenance treatment with inhaled corticosteroids in pure episodic (viral) wheeze was ineffective, but maintenance as well as intermittent montelukast was shown to have an efficient role in both episodic and multi trigger wheeze. Furthermore, their advantage to inhaled corticosteroids is that leukotriene receptor antagonists do not affect short-term lower leg growth rate in prepubertal children.Key words: Leukotriene antagonist; antihistamines; allergic rhinitis; asthma. ÖzetYaln›z bafllar›na veya kombinasyon fleklinde kullan›ld›klar›nda lökotri-yen reseptörleri ve antistaminikler alerjik rinit semptomlar›n› azaltmada etkilidir. Alerjik rinit hastalar›nda H1 antistaminikleri alerjene yan›-t›n erken ve geç dönem yan›tlar› olan aks›rma, kafl›nma, burun akmas› ve nazal konjestiyonu önlemekte ve geçirmektedir. Ast›m hastalar›nda H1-antistaminikleri seçilecek ilaçlar olmamalar›na ra¤men rinitin kontrol alt›na al›nmas› ayn› zamanda ast›m› da iyilefltirecektir. Orta-a¤›r derecede fliddetli inatç› ast›mda inhale kortikosteroidin ek tedavi olarak verilemedi¤i veya uzun etkili beta agonistin alternatif olmad›¤› durumlarda hafif derecede ve inatç› ast›m›n alternatif tedavisi olarak montelukast gibi bir lökotriyen antagonistiyle monoterapi uygulanabilir. Alerjik rinitte monoterapi olarak montelukast etkili bir ilaç olmas›na ra¤men yayg›n olarak antistamin veya intranazal kortikosteroide ek olarak öne-rilmektedir. Antilökotriyen ilaçlar yine pediyatrik ast›m›n tedavisinde yayg›n biçimde kullan›lmaktad›r. Çocuklarda kortikosteroitler inhalasyonlar›yla idame tedavisi olarak saf epizodik (viral) h›fl›lt›l› solunum (wheezing) tedavisinde etkisiz olmalar›na ra¤men hem deva...

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Urticária

Cited by 15 publications

References 37 publications

Evaluation of D-dimer serum levels among patients with chronic urticaria, psoriasis and urticarial vasculitis

Evaluation of D-dimer serum levels among patients with chronic urticaria, psoriasis and urticarial vasculitis

Histamina, receptores de histamina e anti-histamínicos: novos conceitos

Role of leukotriene antagonists and antihistamines in treatment of allergic rhinitis and asthma comorbidity

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