Hiperandrogenismo e pele: síndrome do ovário policístico e resistência periférica à insulina

Yarak, Samira; Bagatin, Ediléia; Hassun, Karime Marques; Parada, Meire Odete Américo Brasil; Filho, Sérgio Talarico

doi:10.1590/s0365-05962005000400011

Cited by 26 publications

(19 citation statements)

References 88 publications

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“…Next, the patients were referred for blood sampling to measure the hormones that constitute the androgen cascade: dehydroepiandrosterone (DHEA), total testosterone (TT), free testosterone (FT), androstenedione and dehydroepiandrosterone sulfate (DHEA-S). 28 In parallel, 16 volunteers without any sebaceous hyperplasia lesions and of a similar age to the women in the study group were paired, one to one, with a patient from the study group (Table 1).…”

Section: Methodsmentioning

confidence: 99%

Hiperplasia sebácea cutânea: estudo piloto para a correlação da doença com hormônios androgênios

Tagliolatto¹,

Alchorne

Enokihara

2011

An. Bras. Dermatol.

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FUNDAMENTOS: As glândulas sebáceas são suscetíveis à ação dos hormônios androgênios e apresentam proliferação benigna com a idade, ou seja, hiperplasia. OBJETIVOS: Estudo piloto para verificar se há correlação entre a taxa de hormônios masculinos circulantes e o aumento da incidência da hiperplasia das glândulas sebáceas. MÉTODOS: 16 pacientes do sexo feminino, com diagnóstico de hiperplasia sebácea cutânea, foram comparados a um grupo-controle de mesmo gênero e idades semelhantes, sem a doença. Ambos os grupos foram submetidos a testes de dosagem sanguínea para avaliação das taxas de hormônios androgênios circulantes (testosterona livre e total, androstenediona). Os resultados foram tabulados e analisados estatisticamente. RESULTADOS: Os dados demonstraram não haver mudanças nos níveis de hormônios masculinos circulantes dos pacientes com hiperplasia sebácea cutânea, quando comparados ao grupo-controle. CONCLUSÃO: Os dados sugerem que não há alterações estatisticamente significantes nas taxas dos hormônios circulantes (testosterona livre e total, androstenediona, deidroepiandrosterona, sulfato de deidroepiandrosterona) dos pacientes com hiperplasia sebácea cutânea.

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Section: Methodsmentioning

confidence: 99%

Hiperplasia sebácea cutânea: estudo piloto para a correlação da doença com hormônios androgênios

Tagliolatto¹,

Alchorne

Enokihara

2011

An. Bras. Dermatol.

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“…In adult women, acne may or may not be related to clinical hyperandrogenism manifesting with alopecia, hirsutism and seborrhea (SAHA syndrome [8]). In a minority of the cases, acne is associated with hyperandrogenemia caused by polycystic ovary syndrome associated with irregular menses, and changes of the secondary sex characteristics [9]. In these cases only, laboratory investigation should include measurements of free serum testosterone (T), dehydroepiandrosterone sulfate (DHEA-S), luteinizing hormone (LH) and follicle-stimulating hormone (FSH) [9,10].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Acne Vulgaris in Patients with Down Syndrome

et al. 2010

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Background/Objective: Acne vulgaris exhibits a worldwide prevalence of up to 95% among adolescents. On the other hand, Down syndrome is an autosomal chromosomal disorder with associated dermatoses and a tendency to obesity. There are no data on its association with acne. Our aim was to detect the prevalence of acne, its forms and associated factors in Down syndrome. Method: A cross-sectional study including 89 subjects aged 10–28 years from Associação de Pais e Amigos dos Excepcionais-São Paulo to verify acne, metabolic and hormonal disorders by interview, clinical and laboratory examinations. Results: We evaluated 49 (55%) males and 40 (45%) females. A weak agreement between self-estimation for acne and examination result was detected. The overall prevalence of acne was 70.8%: 83.7% in males and 55% in females. The prevalence of acne in the age groups 10–17 and 18–28 was 62 and 78.7%, respectively. Facial comedonal acne was mostly detected. The prevalence of obesity was 40%, that of metabolic disorders 7% and that of hyperandrogenism (in females) 15%. Except for gender, no other factor evaluated correlated with acne. Conclusion: A low prevalence of acne in Down syndrome, a predominance in males aged 18–28 and a facial comedonal form were detected. An association with obesity, metabolic disorders or hyperandrogenemia was not assessed.

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“…Insulin also acts on the ovaries by stimulating steroidogenesis in theca and granulosa cells, and enhances the stimulatory effect of LH through upregulation of the LH receptor and; in the pituitary can increase the sensitivity of the gonadotrophic cells to the action of GnRH, further increasing the stimulation to steroidogenesis. Obesity, especially central obesity, induces a state of insulin resistance and in hormonal response, there is hyperinsulinemia to compensate [7]. In addition, some studies suggest that increased rates of abortion and early pregnancy loss, which is very common in obese women, can be attributed to a reduction in oocyte quality, affecting the development of the embryo, leading to a decrease in implantation rate and abnormal development of the trophoblast [6].…”

Section: Discussionmentioning

confidence: 99%

Use of Intragastral Balloon and Increase in Fertility: Case Report

Torres¹,

Ribeiro²,

Reis³

et al. 2018

JPP

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Abstract:The IGB (intragastric balloon) is a silicone device, inflated by endoscopy in the gastric cavity, with physiological saline and a blue dye, up to the volume of 700 mL, and used for a maximum of 6 months. It is indicated for patients with BMI ≥27 kg/m² that have not undergone previous gastric surgery. In obese women there is a decrease in peripheral resistance fertility, and the weight loss achieved in bariatric surgery improves fertility due to reduced subcutaneous fat, with lower insulin resistance. Similar results could be achieved through the use of IGB, a less invasive method. The objective of the article is to report the case of a patient who became pregnant using IGB, considering the hypothesis that the increase in fertility was due to weight loss and/or due to the improvement in the self-esteem (and sexual life) of patient. We selected 13 articles from PubMed, UpToDate, JAMA and a case report. Results: Balloon with drawal occurred on 05/02/16 after positive pregnancy test with final weight 65.5 kg and BMI 25.91 kg/m². Conclusions: Weight loss actually favors fertility, but self-esteem may have been instrumental in improving the sex life, enabling conception.

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Hiperandrogenismo e pele: síndrome do ovário policístico e resistência periférica à insulina

Cited by 26 publications

References 88 publications

Hiperplasia sebácea cutânea: estudo piloto para a correlação da doença com hormônios androgênios

Hiperplasia sebácea cutânea: estudo piloto para a correlação da doença com hormônios androgênios

Prevalence of Acne Vulgaris in Patients with Down Syndrome

Use of Intragastral Balloon and Increase in Fertility: Case Report

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