2005
DOI: 10.1590/s0365-05962005000200002
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Abstract: Lupus erythematosus is a connective tissue autoimmune disorder that demonstrates systemic, cutaneous, or both systemic and cutaneous manifestations. Cutaneous lesions are classified as specific and nonspecific. The variety of clinical manifestations of the disease is reflected in the broad spectrum of laboratory patterns. In this article we describe the distinct subsets of cutaneous lupus erythematosus, correlating them with histopathological, direct immunofluorescence and serological findings. Keywords: Skin … Show more

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Cited by 21 publications
(11 citation statements)
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“…The histological findings are comparable to those on the literature review, like: hydropic degeneration of the basal layer, thickening of the BM, follicular dilation, hyperkeratosis, lymphocyte inflammatory infiltrate, and melanophages on the dermis. 12 From all those, the most relevant findings to the establishment of the diagnosis of LE are the hydropic degeneration of the basal layer and the thickening of the BM, that occurs due to the deposition of reactive immune complexes and, in many cases, is seen only with the progression of the disease. 13 On the present case the identification of the comedones on the anatomopathological examination associated to the related changes permitted the confirmation of the diagnosis of comedonic LE.…”
Section: Discussionmentioning
confidence: 99%
“…The histological findings are comparable to those on the literature review, like: hydropic degeneration of the basal layer, thickening of the BM, follicular dilation, hyperkeratosis, lymphocyte inflammatory infiltrate, and melanophages on the dermis. 12 From all those, the most relevant findings to the establishment of the diagnosis of LE are the hydropic degeneration of the basal layer and the thickening of the BM, that occurs due to the deposition of reactive immune complexes and, in many cases, is seen only with the progression of the disease. 13 On the present case the identification of the comedones on the anatomopathological examination associated to the related changes permitted the confirmation of the diagnosis of comedonic LE.…”
Section: Discussionmentioning
confidence: 99%
“…Purplish, atrophic telangiectasias and erythema multiform-like lesions are less common. 2,3,5,[7][8][9][10] Treatment of the skin lesions consists of photoprotection and low-strength topical corticosteroids. Laser treatment may be necessary for residual telangiectasias.…”
Section: Discussionmentioning
confidence: 99%
“…The most affected organ is the skin, which may be involved in isolation or accompanied by systemic manifestations. 1 , 2 It primarily affects young women between 18 and 30 years regardless of racial group. Genetic, environmental, socio-cultural and demographic differences may contribute to differing incidences as well as the clinical expression of the disease.…”
Section: Introductionmentioning
confidence: 99%