2004
DOI: 10.1590/s0365-05962004000600002
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Abstract: INTRODUÇÃOA resposta imune tem papel fundamental na defesa contra agentes infecciosos e se constitui no principal impedimento para a ocorrência de infecções disseminadas, habitualmente associadas com alto índice de mortalidade. É também conhecido o fato de que, para a quase-totalidade das doenças infecciosas, o número de indivíduos expostos à infecção é bem superior ao dos que apresentam doença, indicando que a maioria das pessoas tem condições de destruir esses microorganismos e impedir a progressão da infecç… Show more

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Cited by 86 publications
(54 citation statements)
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“…This fact is supported by experiments demonstrating that several infl ammatory agents reduced ADFI and G:F, increased body temperature, and increased plasma corticosterone (Klasing et al, 1987;Klasing and Barnes, 1988). The immune response can cause tissue damage and decrease muscle tone and cardiac output, which results in hypotension, poor tissue perfusion, and subsequent cell death (Machado et al, 2004). One hypothesis for the anti-infl ammatory effect of CLA is that supplementation results in increased antigen receptors that regulate genes involved in immune function.…”
Section: Performancementioning
confidence: 92%
“…This fact is supported by experiments demonstrating that several infl ammatory agents reduced ADFI and G:F, increased body temperature, and increased plasma corticosterone (Klasing et al, 1987;Klasing and Barnes, 1988). The immune response can cause tissue damage and decrease muscle tone and cardiac output, which results in hypotension, poor tissue perfusion, and subsequent cell death (Machado et al, 2004). One hypothesis for the anti-infl ammatory effect of CLA is that supplementation results in increased antigen receptors that regulate genes involved in immune function.…”
Section: Performancementioning
confidence: 92%
“…Macrophages are essential for mediating the first steps of an effective antifungal host defense, and neutrophils are essential to eliminate the fungal invasion, as evidenced by the observation that immunosuppression with prolonged neutropenia is a major risk factor for invasive fungal infections (Becker et al, 2015). Phagocytes can develop protective mechanism against fungi, destroying them via oxidative and non-oxidative mechanisms (Machado et al, 2004; Liu et al, 2014). …”
Section: Introductionmentioning
confidence: 99%
“…Também pode exacerbar a produção de citocinas pró-inflamatórias e produzir danos aos tecidos, com diminuição do tônus muscular e débito cardíaco que resulta em hipotensão e má perfusão tecidual e, portanto, em morte celular (MACHADO et al, 2004). A morte de quatro animais no presente estudo, após aplicação intramuscular de 80 μg de LPS/kg de peso vivo, indicou que a dose de LPS utilizada foi elevada e sugere ajustes em futuros protocolos de pesquisas, quanto à dosagem e via de aplicação.…”
Section: Resultsunclassified