Estudo histopatológico de casos de eritema crônico migratório diagnosticados em Manaus

Melo, Itelvina Suriadakis de; Gadelha, Alcidarta dos Reis; Ferreira, Luíz Carlos de Lima

doi:10.1590/s0365-05962003000200004

Cited by 11 publications

(8 citation statements)

References 10 publications

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“…11 However, spirochetes were detected in skin biopsy from one patient only. 15 Therefore, investigation of Borrelia infection presence in the Amazon region is pivotal to further understand ECM/LB epidemiology, as well as because its clinical and laboratorial implications.…”

Section: Introductionmentioning

confidence: 99%

Antibody reactivity to Borrelia burgdorferi sensu stricto antigens in patients from the Brazilian Amazon region with skin diseases not related to Lyme disease

Santos

Ribeiro‐Rodrigues

Løbo³

et al. 2010

Int J Dermatology

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In the present study, we report the occurrence of borreliosis in patients from the Brazilian Amazonic region. Nineteen (7.2%) out of 270 dermatological patients with different skin diseases (no one with clinical Lyme disease), tested positive by ELISA for Borrelia burgdorferi. Serum samples from 15 out of the 19 ELISA-positive patients were further evaluated by Western blot. Presence of Borrelia burgdorferi specific IgG was confirmed in eight (53.3%) out of the 15 patients. All eight patients with ELISA and Western blot positive reactions were treated with doxycycline, according to the Centers for Disease Control and Prevention guidelines. One of them had clinical manifestations of colagenosis and was sent to the Department of Internal Medicine for further investigation. Data presented here suggested that borreliosis "lato sensu" is in the Brazilian Amazon region.

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Section: Introductionmentioning

confidence: 99%

Antibody reactivity to Borrelia burgdorferi sensu stricto antigens in patients from the Brazilian Amazon region with skin diseases not related to Lyme disease

Santos

Ribeiro‐Rodrigues

Løbo³

et al. 2010

Int J Dermatology

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“…The histopathological exam of the skin biopsy or the culture in BSK medium as part of the search for the etiological agent are important tools for both specific and differential diagnosis. 27 Serological methods have been widely used in studies on anti-IgG and anti-IgM antibodies in humans and animals in risk or enzootic areas for borreliosis, serving as a support both to confirm clinical cases and to prepare an epidemiological profile of this disease. 13 In Brazil, the indirect ELISA test to detect anti-B.…”

Section: Diagnostic Methodsmentioning

confidence: 99%

“…In skin biopsies of 31 patients from Manaus, Melo et al 27 detected spongiosis in 15 (44.12%). When examining the dermis, 8 patients (15.69%) had an infiltrate composed of lymphocytes, histiocytes and eosinophils.…”

Section: -4mentioning

confidence: 99%

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Borreliose de Lyme simile: uma doença emergente e relevante para a dermatologia no Brasil

Fonseca

Salles

et al. 2005

An. Bras. Dermatol.

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This review article presents diseases related to spirochetes of the genus Borrelia, which are the etiological agents of many human and animal diseases. Focus was given to the Borrelia burgdorferi sensu lato complex, including nine different species that cause diseases often with multisystemic involvement and raising interest to many medical specialties, such as Dermatology, Rheumatology, Cardiology and Neurology. Due to differences concerning the etiologic agent, clinical and laboratorial presentations, when comparing with B. burgdorferi, B. garinii and B. afzelli, the infection must be referred as Lyme disease-like illness in Brazil. The recurrent erythema migrans is the main clinical manifestation of borreliosis observed in Brazil and in other countries. The classical reddish macular or papular skin lesion shows expanding features and is tick bite related; additionally, multiple secondary similar lesions may appear far from the original site. The clinical presentation of the disease, mainly skin manifestation, is the main diagnostic parameter, while serologic exams only confirm the clinical suspicion. Keywords: Borrelia; Lyme disease; Erythema migrans. Resumo

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“…Histological analysis of erythema migrans has revealed the presence of spirochetes (19). Melo et al (19) performed a histopathological study of 31 patients with erythema migrans diagnosed in Manaus, Amazonas State, and identified spirochetes in one case (3.22%) using Warthin-Starry silver stain.…”

Section: Background Of the Study Of Lyme Disease-like Syndrome In Brazilmentioning

confidence: 99%

Description of Lyme disease-like syndrome in Brazil: is it a new tick borne disease or Lyme disease variation?

Mantovani

Costa²,

Gauditano

et al. 2007

Braz J Med Biol Res

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An emerging clinical entity that reproduces clinical manifestations similar to those observed in Lyme disease (LD) has been recently under discussion in Brazil. Due to etiological and laboratory particularities it is named LD-like syndrome or LD imitator syndrome. The condition is considered to be a zoonosis transmitted by ticks of the genus Amblyomma, possibly caused by interaction of multiple fastidious microorganisms originating a protean clinical picture, including neurological, osteoarticular and erythema migrans-like lesions. When peripheral blood of patients with LD-like syndrome is viewed under a dark-field microscope, mobile uncultivable spirochete-like bacteria are observed. PCR carried out with specific or conservative primers to recognize Borrelia burgdorferi sensu stricto or the genus Borrelia has been negative in ticks and in biological samples. Two different procedures, respectively involving hematoxylin and eosin staining of cerebrospinal fluid and electron microscopy analysis of blood, have revealed spirochetes not belonging to the genera Borrelia, Leptospira or Treponema. Surprisingly, co-infection with microorganisms resembling Mycoplasma and Chlamydia was observed on one occasion by electron microscopy analysis. We discuss here the possible existence of a new tick-borne disease in Brazil imitating LD, except for a higher frequency of recurrence episodes observed along prolonged clinical follow-up.

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Estudo histopatológico de casos de eritema crônico migratório diagnosticados em Manaus

Cited by 11 publications

References 10 publications

Antibody reactivity to Borrelia burgdorferi sensu stricto antigens in patients from the Brazilian Amazon region with skin diseases not related to Lyme disease

Antibody reactivity to Borrelia burgdorferi sensu stricto antigens in patients from the Brazilian Amazon region with skin diseases not related to Lyme disease

Borreliose de Lyme simile: uma doença emergente e relevante para a dermatologia no Brasil

Description of Lyme disease-like syndrome in Brazil: is it a new tick borne disease or Lyme disease variation?

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